==================================CMR57================================== 57. Follow up test for colonic cancer after surgery. Tests such as 1. Chest X-rays 2. Cat Scan 3. Liver Scan 4. Full Lung Tomograms 5. Physical examination 6. Carcino-embryonic antigen 7. Liver function tests SGOT SGPT Bilirubin ALK. Phos 1 UI - 87102207 AU - Lottich SC ; Szpak CA ; Johnston WW ; Thor A ; Schlom J TI - Phenotypic heterogeneity of a tumor-associated antigen in adenocarcinomas of the colon and their metastases as demonstrated by monoclonal antibody B72.3. AB - To determine the potential antigenic heterogeneity which might exist between a primary colon carcinoma lesion and its metastases, we stained the formalin and Zenker's fixed paraffin-embedded tissues from the resection specimens of 12 patients with Duke's Stage C adenocarcinoma of the colon with monoclonal antibody (MAb) B72.3. This MAb previously has been shown to react with a high molecular weight tumor-associated glycoprotein (termed TAG-72), which is selectively expressed in adenocarcinomas versus normal adult tissue. Five to 90% of malignant cells from all primary lesions stained with MAb B72.3 in paraffin-embedded tissue. A significantly diminished percentage of cells stained from the metastases in lymph nodes and distant sites. Pearson correlation coefficients showed that the antigenic expression of the metastasis in the lymph node was a better indicator of the antigenic expression of the metastasis in the distal site than was the primary lesion in the colon. These findings suggest that the effective use of monoclonal antibodies for diagnostic imaging or therapeutic purposes may require the evaluation of the antigenic expression in regional node metastases rather than that of the primary lesion. MH - Adenocarcinoma/*IMMUNOLOGY/SECONDARY/SURGERY ; Antibodies, Monoclonal ; Antigens, Neoplasm/*ANALYSIS ; Colonic Neoplasms/ *IMMUNOLOGY/SURGERY ; Follow-Up Studies ; Histocytochemistry ; Human ; IgG ; Immunoenzyme Technics ; Lymphatic Metastasis ; Neoplasm Staging ; Phenotype ; Stains and Staining ; Support, U.S. Gov't, P.H.S. SO - Cancer Invest 1986;4(5):387-95 2 UI - 87052865 AU - Keramati B ; Whitley NO ; Didolkar MS ; Whitley JE TI - Computed tomography of the liver after dearterialization and intraarterial chemotherapy. AB - Hepatic dearterialization by ligation of the main hepatic artery followed by local intraarterial chemotherapy was performed in 24 patients with clinically isolated but unresectable hepatic metastasis after local resection of carcinoma of the colon. Computed tomography of the abdomen and laboratory parameters were used both to stage and follow-up these patients. Computed tomography changes following dearterialization and chemotherapy of the liver are described. Computed tomography is a valuable technique for both staging and follow-up this group of patients. MH - Aged ; Aged, 80 and over ; Antineoplastic Agents/*ADMINISTRATION & DOSAGE ; Colonic Neoplasms ; Female ; Hepatic Artery/*SURGERY ; Human ; Infusions, Intra-Arterial ; Ligation ; Liver Neoplasms/ BLOOD SUPPLY/DRUG THERAPY/RADIOGRAPHY/*SECONDARY ; Liver/ *RADIOGRAPHY ; Male ; Middle Age ; Prospective Studies ; *Tomography, X-Ray Computed SO - J Comput Tomogr 1986 Oct;10(4):303-7 3 UI - 87031314 AU - Gomberg JS ; Friedman AC ; Radecki PD ; Grumbach K ; Caroline DF TI - MRI differentiation of recurrent colorectal carcinoma from postoperative fibrosis. AB - The potential applications of magnetic resonance imaging in the differential diagnosis of recurrent colorectal carcinoma from postoperative fibrosis are described. Correlation with computed tomographic findings is presented in 2 cases. MH - Adenocarcinoma/*DIAGNOSIS/RADIOTHERAPY/SURGERY ; Aged ; Case Report ; Colon/*PATHOLOGY ; Colonic Neoplasms/*DIAGNOSIS/ RADIOTHERAPY/SURGERY ; Comparative Study ; Diagnosis, Differential ; Fibrosis ; Human ; Male ; Neoplasm Recurrence, Local/*DIAGNOSIS ; *Nuclear Magnetic Resonance ; Postoperative Complications ; Rectal Neoplasms/*DIAGNOSIS/RADIOTHERAPY/SURGERY ; Rectum/*PATHOLOGY ; Tomography, X-Ray Computed SO - Gastrointest Radiol 1986;11(4):361-3 4 UI - 87001986 AU - Denstman F ; Rosen L ; Khubchandani IT ; Sheets JA ; Stasik JJ ; Riether RD TI - Comparing predictive decision rules in postoperative CEA monitoring. AB - To evaluate the usefulness of serial postoperative carcinoembryonic antigen (CEA) assays, seven previously published decision rules for predicting tumor recurrence were compared retrospectively using CEA values from 214 patients followed 36 to 120 months after surgery for colorectal carcinoma. Decision rules employing cutoff values to predict tumor recurrence were found inadequate for the asymptomatic patient. This attenuation of prognostic usefulness appeared attributable to inadequacies of CEA assays for predicting late recurrences. From these analyses, elevated CEA results without other objective evidence might be insufficient to justify second-look surgery. In addition, late recurring tumors tended not to cause elevated CEA levels. MH - Adult ; Aged ; Carcinoembryonic Antigen/*ANALYSIS ; Colonic Neoplasms/IMMUNOLOGY ; Diagnostic Errors ; Female ; Human ; Male ; Middle Age ; Neoplasm Recurrence, Local/*IMMUNOLOGY/SURGERY ; Rectal Neoplasms/IMMUNOLOGY ; Reoperation ; Retrospective Studies ; *Statistics ; Support, Non-U.S. Gov't SO - Cancer 1986 Nov 1;58(9):2089-95 5 UI - 87001722 AU - Corman J ; Arnoux R ; P:eloquin A ; St-Louis G ; Smeesters C ; Giroux L TI - Blood transfusions and survival after colectomy for colorectal cancer. AB - This study was carried out to determine the effect of perioperative blood transfusions on the survival of patients operated on for colorectal cancers. Cox's regression analysis was applied to 281 patients operated for cure of Dukes' stage A, B or C disease. Other variables studied were age, sex, tumour location, and preoperative hemoglobin, lymphocyte and albumin values. Perioperative deaths, pre- and postoperative immunodepression, neoplasia in situ, nonresections and stage D disease were excluded. It was found that the number of units of blood transfused had a strong influence on the prognosis of patients with colorectal cancer, particularly colonic cancers, but the effect could not be demonstrated when rectal cancers were studied separately, perhaps because of the small number of cases. The mechanism of action of blood transfusions seems to be independent of the other analysed variables. The authors suggest that perioperative blood transfusions may have an immunomodulatory effect in patients with colonic cancer, as already shown in recipients of transfused kidney allografts. MH - Aged ; *Blood Transfusion/ADVERSE EFFECTS ; *Colectomy ; Colonic Neoplasms/BLOOD/*MORTALITY/SURGERY ; Comparative Study ; Female ; Hemoglobinometry ; Human ; Leukocyte Count ; Lymphocytes ; Male ; Middle Age ; Prognosis ; Rectal Neoplasms/BLOOD/*MORTALITY/ SURGERY ; Regression Analysis ; Serum Albumin/ANALYSIS ; Time Factors SO - Can J Surg 1986 Sep;29(5):325-9 6 UI - 86297404 AU - Hansell DT ; Davies JW ; Burns HJ TI - Effects of hepatic metastases on resting energy expenditure in patients with colorectal cancer. AB - There are frequent reports that cancer causes an increase in resting energy expenditure (REE), and the presence of hepatic metastases is said to increase REE further. The effect of tumour burden on REE has been measured in 24 patients before and following surgery for colorectal cancer. Fifteen patients had a 'curative' resection whereas nine patients were found to have hepatic metastases at the time of surgery. No significant differences in REE were found between the groups either before surgery or at follow-up, by which time all 15 curative resection patients were tumour free and the remaining nine had progression of their hepatic disease. It is concluded that neither surgical removal of the primary tumour nor progression of metastatic hepatic disease significantly alters REE in patients with colorectal cancer. MH - Aged ; Body Weight ; Caloric Intake ; Colonic Neoplasms/ METABOLISM/*SURGERY ; *Energy Metabolism ; Female ; Human ; Liver Neoplasms/METABOLISM/*SECONDARY ; Male ; Rectal Neoplasms/ METABOLISM/*SURGERY ; Serum Albumin/ANALYSIS ; Support, Non-U.S. Gov't SO - Br J Surg 1986 Aug;73(8):659-62 7 UI - 86271511 AU - Moertel CG ; O'Fallon JR ; Go VL ; O'Connell MJ ; Thynne GS TI - The preoperative carcinoembryonic antigen test in the diagnosis, staging, and prognosis of colorectal cancer. AB - A study of preoperative carcinoembryonic antigen (CEA) levels was conducted in 319 patients with surgically treated colorectal cancer, 272 of whom had disease resectable with curative intent. Only three patients could not be completely followed. All of the remaining 316 patients have been followed for a minimum of 5 years or until death. From the standpoint of diagnosis, the CEA test was more frequently positive (greater than 5 ng/ml) in patients with advanced stage disease, with larger primary tumors, and with more differentiated histopathologic characteristics. It was grossly insensitive in diagnosis of resectable cancer (26%) and was only reasonably reliable (72%) in patients with unresectable and metastatic disease. In relationship to surgical pathology of colorectal cancer, CEA levels were significantly correlated with stage of disease and with size of the primary tumor in Dukes' B lesions, but not with extent of nodal metastasis in Dukes' C lesions. In advanced stage lesions, CEA was inversely correlated with degree of anaplasia. In the overall patient group, and also among resectable patients, the preoperative CEA level was strongly associated with survival after adjustment for the effects of a number of other prognostic factors. Within stages of resectable disease, however, CEA was not significantly associated with survival among patients with Dukes' A and B lesions or Dukes' C lesions with one to three nodes involved. CEA was found to be a significant and independent prognostic determinant only in patients with Dukes' C lesions who had four or more metastatically involved lymph nodes. Under these circumstances, a preoperative CEA level could perhaps be of some value for stratification of Dukes' C patients in randomized colorectal cancer surgical adjuvant trials. The value of this test as a prognostic guide in clinical practice, however, would seem to be limited because of a lack of sensitivity in identifying individual poor prognosis patients. MH - Adult ; Aged ; Carcinoembryonic Antigen/*ANALYSIS ; Colonic Neoplasms/*DIAGNOSIS/MORTALITY/PATHOLOGY/SURGERY ; Evaluation Studies ; Female ; Follow-Up Studies ; Human ; Male ; Middle Age ; Neoplasm Metastasis ; Neoplasm Staging ; Prognosis ; Rectal Neoplasms/*DIAGNOSIS/MORTALITY/PATHOLOGY/SURGERY ; Support, U.S. Gov't, P.H.S. ; Time Factors SO - Cancer 1986 Aug 1;58(3):603-10 8 UI - 86255007 AU - Kimura O ; Kaibara N ; Nishidoi H ; Okamoto T ; Takebayashi M ; Kawasumi H ; Koga S TI - Carcinoembryonic antigen slope analysis as an early indicator for recurrence of colorectal carcinoma. AB - We analyzed the time course of postoperative serum CEA concentrations in 229 patients with histologically confirmed colorectal carcinoma. Preoperative CEA levels were correlated with Dukes' stages, however, the preoperative CEA value was of limited value as a screening procedure. In 42 patients with tumor recurrence after radical resection, a diagnosis of relapse, based on a rise in the CEA concentration, preceded the positive clinical symptoms. Analysis of the CEA time course made it possible to differentiate local tumor recurrence and generalized metastasis, regardless of the histologic type or primary site of the tumor. MH - Carcinoembryonic Antigen/*ANALYSIS ; Colonic Neoplasms/BLOOD/ *DIAGNOSIS/SURGERY ; Diagnosis, Differential ; Follow-Up Studies ; Human ; Neoplasm Circulating Cells ; Neoplasm Recurrence, Local/ BLOOD/*DIAGNOSIS ; Peritoneal Neoplasms/SECONDARY ; Rectal Neoplasms/BLOOD/*DIAGNOSIS/SURGERY SO - Jpn J Surg 1986 Mar;16(2):106-11 9 UI - 86241035 AU - Scott HW Jr ; Sawyers JL ; Weaver FA ; Fletcher JR ; Adkins RB Jr TI - Is ileoproctostomy a reasonable procedure after total abdominal colectomy? AB - A 17-year study has been made of 63 patients who had a variety of colonic disorders treated by total abdominal colectomy with ileorectal anastomosis in four hospitals affiliated with Vanderbilt University. Forty-three of these patients made an uneventful recovery, but 20 others sustained significant complications, nine of which proved to be fatal (hospital mortality rate, 14%). The study shows (and confirms the work of others) that ileorectal anastomosis after total abdominal colectomy is a reasonable procedure that provides satisfactory results on a long-term basis in a majority of patients when strict criteria in patient selection are followed in its application. MH - Adult ; Body Weight ; *Colectomy/ADVERSE EFFECTS ; Colonic Diseases/*SURGERY ; Colonic Neoplasms/*SURGERY ; Emergencies ; Female ; Follow-Up Studies ; Human ; Ileum/PHYSIOPATHOLOGY/ *SURGERY ; Intestines/PHYSIOPATHOLOGY ; Male ; Middle Age ; Postoperative Complications ; Rectum/*SURGERY SO - Ann Surg 1986 Jun;203(6):583-9 10 UI - 86226437 AU - Novis BH ; Gluck E ; Thomas P ; Steele GD ; Zurawski VR Jr ; Stewart R ; Lavin PT ; Zamcheck N TI - Serial levels of CA 19-9 and CEA in colonic cancer. AB - The use of serial carbohydrate antigen (CA) 19-9 assays was assessed by comparison with serial carcino-embryonic antigen (CEA) levels on the plasmas of 53 patients with colorectal carcinoma. The patients had all undergone resection for their primary tumors and in six instances subsequent resections for hepatic metastases. Initial CA 19-9 levels were greater than or equal to 37 U/mL in 22 of the 53 patients (41%) and in 68% of the patients with metastatic disease. Similar trends of serial CA 19-9 and CEA levels were found in 79% of the 53 patients. One patient with initially normal CEA levels had elevated CA 19-9 levels from the start. In ten of the 53 patients (19%), serial CA 19-9 levels remained low despite tumor recurrence or progression, and despite increasing CEA levels above 5 ng/mL. The increasing serial CEA trends predicted recurrence in 88% and increasing CA 19-9 trends in 50% of cases, which was increased to 70% by including trends of CA 19-9 levels below 37 U/mL. Following hepatic lobectomy, both serial CEA and CA 19-9 levels decreased rapidly. Used alone, serial CA 19-9 levels did not appear to be as sensitive as standard CEA in this retrospective study of selected patients. MH - Adult ; Aged ; Antigens, Neoplasm/*ANALYSIS ; Carcinoembryonic Antigen/*ANALYSIS ; Case Report ; Colonic Neoplasms/DRUG THERAPY/ *IMMUNOLOGY/SURGERY ; Comparative Study ; Female ; Human ; Liver Neoplasms/IMMUNOLOGY/*SECONDARY/SURGERY ; Male ; Middle Age ; Neoplasm Recurrence, Local/IMMUNOLOGY ; Neoplasm Staging ; Palliative Treatment ; Radioimmunoassay ; Rectal Neoplasms/ IMMUNOLOGY/SURGERY SO - J Clin Oncol 1986 Jun;4(6):987-93 11 UI - 86217671 AU - Balslev I ; Pedersen M ; Teglbjaerg PS ; Hanberg-Soerensen F ; Bone J ; Jacobsen NO ; Overgaard J ; Sell A ; Bertelsen K ; Hage E ; et al TI - Postoperative radiotherapy in Dukes' B and C carcinoma of the rectum and rectosigmoid. A randomized multicenter study. AB - Results obtained during the first 5 years of a randomized study of postoperative radiotherapy (50 Gy) are presented. Criteria for randomization were fulfilled in 494 of 861 patients with Dukes' B and C tumors, when the trial was closed. Severe complications from radiotherapy approximated 10%. Probability of survival without local failure within 24 months was significantly higher after radiotherapy in patients with Dukes' C tumors, and the time of local failure was delayed 1 year. Patients with Dukes' B tumors had no benefit from radiotherapy. Risks of distant metastases and death were not influenced by radiotherapy in the main groups. Plasma-CEA measurements were evaluated blindly, and radiotherapy changed the critical levels of CEA for detection of recurrent cancer. It was concluded that patients with Dukes' C tumors may benefit from radiotherapy and plasma-CEA levels are influenced by radiotherapy, which may be important, when these are used in screening for recurrent cancer. MH - Actuarial Analysis ; Adult ; Aged ; Carcinoembryonic Antigen/ ANALYSIS ; Clinical Trials ; Combined Modality Therapy ; Female ; Human ; Male ; Middle Age ; Neoplasm Metastasis ; Neoplasm Recurrence, Local/IMMUNOLOGY ; Neoplasm Staging ; Random Allocation ; Rectal Neoplasms/MORTALITY/*RADIOTHERAPY/SURGERY ; Sigmoid Neoplasms/MORTALITY/*RADIOTHERAPY/SURGERY SO - Cancer 1986 Jul 1;58(1):22-8 12 UI - 86214519 AU - Larson GM ; Bond SJ ; Shallcross C ; Mullins R ; Polk HC Jr TI - Colonoscopy after curative resection of colorectal cancer. AB - Colonoscopy is generally considered to be an important part of the follow-up program for patients who have undergone curative resection of colorectal cancer. However, there are few data available concerning the frequency with which colonoscopy should be performed and for what length of time after operation. Since 1978, our policy has been to examine the colon annually in these patients using colonoscopy alternating with barium enema. We have evaluated the results in 100 patients over a four-year period. Based on size and histology, the significant colonoscopic findings were new colon cancers in three patients and 11 polyps demonstrating increased risk for malignancy in nine patients. This represents an interval yield of 3% per year. From these results and other reports, we recommend that these patients undergo total colonoscopy in the perioperative period to identify and remove synchronous lesions of the colon, and that examination of the remaining colon should be performed annually, preferably with colonoscopy, for at least the first four years after curative resection. MH - Barium Sulfate/DIAGNOSTIC USE ; Carcinoembryonic Antigen/ANALYSIS ; Colon/PATHOLOGY ; Colonic Neoplasms/DIAGNOSIS/PATHOLOGY/ *SURGERY ; *Colonoscopy ; Enema ; Evaluation Studies ; Human ; Intestinal Polyps/DIAGNOSIS ; Male ; Middle Age ; Neoplasm Recurrence, Local/DIAGNOSIS ; Rectal Neoplasms/PATHOLOGY/*SURGERY ; Sigmoidoscopy ; Time Factors SO - Arch Surg 1986 May;121(5):535-40 13 UI - 86208721 AU - Wilking N ; Petrelli NJ ; Herrera L ; Holyoke ED ; Mittelman A TI - Abdominal exploration for suspected recurrent carcinoma of the colon and rectum based upon elevated carcinoembryonic antigen alone or in combination with other diagnostic methods. AB - Thirty-six patients underwent abdominal exploration due to elevated carcinoembryonic antigen (CEA) levels after a curative resection for carcinoma of the colon and rectum. Three groups were evaluated. In group 1, CEA elevation alone was the indication for the exploration in 13 asymptomatic patients. In group 2, 13 other asymptomatic patients underwent exploration because of elevated CEA levels in combination with other findings. In group 3, ten patients were symptomatic with an elevated CEA level at the time of exploration. Five patients from groups 1 and 2 underwent a curative resection for recurrent tumor (14 per cent). Three of these patients are still alive more than five years after exploration. Nine patients had negative findings at exploration for tumor recurrence (25 per cent false-positive results). Six of these patients are alive while three have died of metastatic disease. Twenty-two of the 36 patients (61 per cent) had unresectable disease at the time of exploration. Four of these patients underwent some form of surgical palliative procedure. Considering the five patients who underwent a curative resection with the latter four patients, this results in 25 per cent of the patients benefitting from surgical exploration. MH - Adult ; Aged ; Carcinoembryonic Antigen/*ISOLATION & PURIFICATION ; Colonic Neoplasms/*BLOOD/DIAGNOSIS/SURGERY ; False Positive Reactions ; Female ; Follow-Up Studies ; Human ; Male ; Middle Age ; Neoplasm Recurrence, Local/*BLOOD/DIAGNOSIS/SURGERY ; Prognosis ; Rectal Neoplasms/*BLOOD/DIAGNOSIS/SURGERY SO - Surg Gynecol Obstet 1986 May;162(5):465-8 14 UI - 86107671 AU - Cunningham L ; Stocking B ; Halter SA ; Kalemeris G TI - Immunoperoxidase staining of carcinoembryonic antigen as a prognostic indicator in colorectal carcinoma. AB - Immunoperoxidase staining for carcinoembryonic antigen (CEA) was performed on 192 colorectal carcinomas to determine: whether tissue staining can be substituted for preoperative serum CEA levels, and whether patient survival can be predicted by these parameters. The overall incidence of positive tissue staining was 75 percent, which was similar to the elevated serum level percentage of 73 percent. Both the serum CEA level and the CEA tissue stain correlated with patient survival in Dukes' stage C patients. There was no correlation between tissue CEA stain and tumor differentiation. Positive tissue stain and elevated preoperative serum CEA identified patients with poor prognosis in Dukes' stage D only. This study shows that tissue staining with immunoperoxidase may be substituted for preoperative serum levels for CEA. The combination of these two parameters, however, does not identify patients at greater risk for recurrence than either procedure alone. MH - Adenocarcinoma/*ANALYSIS/MORTALITY/PATHOLOGY/SURGERY ; Carcinoembryonic Antigen/*ANALYSIS ; Colonic Neoplasms/*ANALYSIS/ MORTALITY/PATHOLOGY/SURGERY ; Human ; Immunoenzyme Technics ; Prognosis ; Rectal Neoplasms/*ANALYSIS/MORTALITY/PATHOLOGY/ SURGERY ; Support, U.S. Gov't, Non-P.H.S. SO - Dis Colon Rectum 1986 Feb;29(2):111-6 15 UI - 86095166 AU - Freeny PC ; Marks WM ; Ryan JA ; Bolen JW TI - Colorectal carcinoma evaluation with CT: preoperative staging and detection of postoperative recurrence. AB - CT was performed prior to surgery in 103 patients with colorectal carcinoma to assess its value in staging the tumor. Preoperative IBD scans had sensitivities and specificities of 72.7% and 98.9% in detection of liver metastases, 25.9% and 96% in detection of lymph node metastases, and 61.2% and 80.6% in detection of local extension. Compared with the Duke's classification, CT correctly staged only 47.5% of patients: 16.6% were upstaged, and 83.3% were downstaged. Recurrent tumors developed in 11 of 67 patients followed for more than 24 months. CT depicted recurrence in six patients scanned prior to 12 months. Routine scans obtained at 12 months depicted unsuspected tumor recurrence in three of four patients with proved recurrent disease (one patient with pulmonary metastases did not undergo CT). This study indicates that because of the poor accuracy of CT in preoperative local staging of colorectal carcinoma, it has virtually no useful clinical role in this regard. However, preoperative CT evaluation of the liver can be useful. Routine postoperative CT, combined with fine-needle aspiration biopsy, is useful for detection of recurrent tumor. MH - Carcinoembryonic Antigen/ANALYSIS ; Colonic Neoplasms/PATHOLOGY/ *RADIOGRAPHY/SURGERY ; Evaluation Studies ; Human ; Laparotomy ; Liver Neoplasms/RADIOGRAPHY/*SECONDARY ; Lymphatic Metastasis ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local/*RADIOGRAPHY ; Neoplasm Staging ; Prospective Studies ; Random Allocation ; Rectal Neoplasms/PATHOLOGY/*RADIOGRAPHY/SURGERY ; Time Factors ; *Tomography, X-Ray Computed SO - Radiology 1986 Feb;158(2):347-53 16 UI - 86093126 AU - Weisman Z ; Shani A ; Fink A ; Shindel A ; Sela A ; Wechsler U ; Pfeffermann R ; Bentwich Z TI - Leukocyte adherence inhibition assay in the diagnosis and follow-up of colorectal cancer patients. AB - Antitumor immune response to colorectal cancer extract was tested by the tube leukocyte adherence inhibition (LAI) assay. Of 70 colorectal cancer patients, 38 (54%) were LAI-positive. In contrast, 15 of 159 (9%) healthy individuals and 2 of 28 (7%) patients with nonmalignant diseases were positive. The LAI activity disappeared a few months after surgery and remained negative in patients with no evidence of disease as well as in patients with disseminated progressed disease. A change of LAI from negative to positive during the follow up period correlated in some cases with the recurrence of the disease, but was observed also in cases with no clinical evidence of disease. MH - Colonic Neoplasms/*IMMUNOLOGY/SURGERY ; Follow-Up Studies ; Human ; Leukocyte Adherence Inhibition Test ; Neoplasm Metastasis ; Neoplasm Recurrence, Local ; Rectal Neoplasms/*IMMUNOLOGY/SURGERY ; Support, U.S. Gov't, P.H.S. SO - Oncology 1986;43(1):23-6