==================================CMR47==================================
47.  Please do literature search for any relationship between chloroquine
     and low blood pressure in people with pre-existing hypertension.  Also
     possible interaction with diuretics to exaggerate hypotensive effect.
1
UI  - 86269105
AU  - Wuthrich RP ; Vallotton MB
TI  - Factors regulating prostaglandin E2 biosynthesis in renal
      cortical tubular cells.
AB  - Prostaglandin synthesis by isolated rat renal cortical tubular
      cells was studied in vitro with a superfusion system. The cells
      were introduced in Teflon chambers and intermittently stimulated.
      The PGE2 production was measured in the effluent. ANG II
      (10(-10)-10(-6)M) induced a dose-dependent increase in PGE2
      synthesis. Saralasin antagonized the response to ANG II.
      Hyperosmolar mannitol or NaCl and Ca2+-ionophore A23187 also
      stimulated PGE2 synthesis. The PGE2 response to all stimuli was
      blocked in Ca2+-free media containing EGTA. The Ca2+-channel
      blocker nifedipine (10(-10)-10(-6)M) did not significantly
      inhibit the PGE2 response to ANG II, hyperosmolar mannitol or
      NaCl, and A23187, whereas the phospholipase-inhibitors
      p-bromophenacyl bromide (10(-4)M) and chloroquine (10(-4)M)
      inhibited the response. Thus, PGE2 synthesis in response to these
      stimuli in rat renal cortical tubular cell is a Ca2+-dependent
      process, acting via phospholipases by a mechanism which does not
      appear to involve voltage-dependent Ca2+-channels.
MH  - A-23187/PHARMACODYNAMICS ; Acetophenones/PHARMACODYNAMICS ;
      Angiotensin II/PHARMACODYNAMICS ; Animal ; Chloroquine/
      PHARMACODYNAMICS ; Female ; Hypertonic Solutions/PHARMACODYNAMICS
      ; Kidney Tubules, Proximal/DRUG EFFECTS/*METABOLISM ; Mannitol/
      PHARMACODYNAMICS ; Phospholipases A/ANTAGONISTS & INHIBITORS ;
      Prostaglandins E/*BIOSYNTHESIS ; Rats ; Rats, Inbred Strains ;
      Saline Solution, Hypertonic/PHARMACODYNAMICS ; Support, Non-U.S.
      Gov't
SO  - Biochem Pharmacol 1986 Jul 15;35(14):2297-300