==================================CMR19================================== 19. This search is to be conducted on sarcoma arising in teratoma: therapy and prognosis. 1 UI - 87048016 AU - Dehner LP TI - Peripheral and central primitive neuroectodermal tumors. A nosologic concept seeking a consensus. AB - The term primitive neuroectodermal tumor is widely used in the literature for a group of small, round-cell tumors in the central and sympathetic nervous systems and soft tissues as well as a specific diagnostic term for individual neoplasms; however, the contention that these various clinicopathologic entities (neuroblastoma, medulloblastoma, and peripheral neuroepithelioma) are histogenetically related is an unproved hypothesis. Morphologic, cytogenetic, immunohistochemical, biochemical, and in vitro studies have established phenotypic similarities among these putatively related neoplasms whether they originate in the brain, adrenal gland, or soft tissues. Because one tumor resembles another in terms of its phenotypic expression, that does not necessarily imply a common histogenesis. This point has been made by previous investigators. The purpose of this review is to evaluate and discuss the present status of our understanding and some of the controversial aspects of this enigmatic category of neoplasms, mainly occurring in children, known as the primitive neuroectodermal tumors. MH - Cell Differentiation ; Central Nervous System ; Human ; Immunochemistry ; Medulloblastoma/CLASSIFICATION ; Neural Crest/ PATHOLOGY ; Neuroblastoma/*CLASSIFICATION/EMBRYOLOGY/PATHOLOGY ; Neuroepithelioma/CLASSIFICATION/PATHOLOGY ; Peripheral Nerves ; Retinoblastoma/CLASSIFICATION ; Review ; Sarcoma, Ewing's/ CLASSIFICATION ; Teratoma/CLASSIFICATION SO - Arch Pathol Lab Med 1986 Nov;110(11):997-1005 2 UI - 86320440 AU - Malkasian GD Jr ; Podratz KC ; Stanhope CR ; Ritts RE Jr ; Zurawski VR Jr TI - CA 125 in gynecologic practice. AB - Serum CA 125 levels were determined in 64 women with benign ovarian lesions, 92 women with uterine fundal lesions, and six patients who had negative second-look laparotomy for epithelial ovarian carcinoma. Of those with benign lesions, 13 of 31 patients with endometriosis had levels greater than 35 U/ml. Six of 34 patients with endometrial carcinoma had elevated levels before the primary operation, and six of 15 patients with recurrent endometrial carcinoma had elevated levels. The six ovarian cancer patients had had negative findings at second look 7 to 40 months before recurrence. Where close serial levels were available, the level became elevated 2 to 5 months before clinically apparent recurrent disease was noted. MH - Antigenic Determinants/*ANALYSIS ; Antigens, Neoplasm/*ANALYSIS ; Carcinosarcoma/IMMUNOLOGY ; Endometriosis/IMMUNOLOGY ; Female ; Gynecology/METHODS ; Human ; Neoplasm Recurrence, Local/ IMMUNOLOGY ; Neoplasm Staging ; Ovarian Cysts/IMMUNOLOGY ; Ovarian Neoplasms/*IMMUNOLOGY ; Reoperation ; Sarcoma/IMMUNOLOGY ; Teratoma/IMMUNOLOGY ; Time Factors ; Uterine Neoplasms/ *IMMUNOLOGY SO - Am J Obstet Gynecol 1986 Sep;155(3):515-8 3 UI - 86271942 AU - Pardes JG ; Schneider M ; Koizumi J ; Engel IA ; Auh YH ; Rubenstein W TI - Percutaneous needle biopsy of deep pelvic masses: a posterior approach. AB - The classical approach for the fine-needle aspiration biopsy of deep pelvic masses has been through the lower anterior abdominal wall. With this approach, and using either CT or sonographic guidance, bowel or bladder may be unavoidably traversed to reach the mass. We have been using a posterior approach through the sciatic notch, which is a safe and simple procedure, with good results. The biopsy is done with the patient in a prone position, using a 22-gauge biopsy needle. With this technique we have successfully biopsied various neoplastic pelvic entities. MH - Adenocarcinoma/PATHOLOGY ; Adult ; Aged ; Biopsy, Needle/*METHODS ; Case Report ; Female ; Hemangiosarcoma/PATHOLOGY ; Human ; Male ; Middle Age ; Pelvic Neoplasms/DIAGNOSIS/*PATHOLOGY ; Posture ; Rectal Neoplasms/PATHOLOGY ; Teratoma/PATHOLOGY ; Tomography, X-Ray Computed ; Ultrasonic Diagnosis SO - Cardiovasc Intervent Radiol 1986;9(2):65-8 4 UI - 86249871 AU - McClellan DS ; Roscher A TI - Intrascrotal tumors in the older male. AB - Although the greatest incidence of testicular neoplasms is in the age group 20 to 35.9% of all intrascrotal tumors occur in males over 60. They may be classified into four major groups based on the tissue origin of the tumor. The most common group comprising 50% are lymphoreticular neoplasms or lymphomas. They occur in both blacks and whites, result in a diffuse enlargement of the testis and commonly involve the epididymis and cord. Prognosis is poor and survival is usually less than two years. Germ cell tumors comprise 25% and the tumors are usually large. Most of them are the classical seminoma which has a good prognosis following orchiectomy and retroperitoneal radiation. A few are the spermatocytic seminoma which is usually benign. Three percent are teratocarcinoma with embryonal elements which is highly malignant and survival less than two years. Ten percent are tumors of gonadal stromal origin. There are two types, the Leydig cell and the more rare Sertoli cell. About one-fourth of these patients develop gynecomastia and some a decrease in libido. The prognosis is good as less than 10% of these tumors are malignant. Neoplasms of supportive and paratesticular structures comprise a heterogeneous group of benign and malignant lesions and comprise about 15% of intrascrotal tumors. Most of them have the same features as tumors of similar tissues encountered throughout the body. They are the mesothelioma or adenomatoid tumor, fibroma, rhabdomyosarcoma, leiomyoma, lipoma, liposarcoma, mucinous cystadenocarcinoma, and leiomyosarcoma. As in all intrascrotal tumors, the diagnosis, treatment, and prognosis are based on the microscopic findings after removal of the tumor. MH - Age Factors ; Aged ; Dysgerminoma/OCCURRENCE/PATHOLOGY ; Human ; Leydig Cell Tumor/OCCURRENCE/PATHOLOGY ; Male ; Middle Age ; Rhabdomyosarcoma/OCCURRENCE/PATHOLOGY ; Sertoli Cell Tumor/ OCCURRENCE/PATHOLOGY ; Teratoma/OCCURRENCE/PATHOLOGY ; Testicular Neoplasms/OCCURRENCE/*PATHOLOGY/THERAPY SO - Int Surg 1986 Jan-Mar;71(1):51-2 5 UI - 86214517 AU - Cohen MD ; Weetman RM ; Provisor AJ ; Grosfeld JL ; West KW ; Cory DA ; Smith JA ; McGuire W TI - Efficacy of magnetic resonance imaging in 139 children with tumors. AB - One hundred thirty-nine children with neoplasms were studied using magnetic resonance imaging (MRI). This procedure was as accurate as computed tomography in predicting tumor histology, except that MRI was unable to detect small areas of tumor calcification. Magnetic resonance imaging could accurately identify the organ of origin of tumor masses and differentiate soft tissue from fat, fluid, or hemorrhage. In addition, MRI was helpful in planning surgery in many cases: It was better than computed tomography in defining the size and extent of soft-tissue tumor masses. It was accurate in defining the extent of the spread of bone sarcomas in the bone marrow. Without requiring the injection of intravenous contrast agents, it accurately defined displacement, encasement, or invasion of major abdominal blood vessels by Wilms' tumors and neuroblastomas. As a means of evaluating pediatric neoplasms, MRI is noninvasive, painless, and well tolerated by children, and it uses no radiation. MH - Adolescence ; Adrenal Gland Neoplasms/DIAGNOSIS ; Bone Neoplasms/ DIAGNOSIS ; Child ; Child, Preschool ; Comparative Study ; Diagnosis, Differential ; Hodgkin's Disease/DIAGNOSIS ; Human ; Infant ; Infant, Newborn ; Kidney Neoplasms/DIAGNOSIS/PATHOLOGY ; Lymphoma/DIAGNOSIS ; Neoplasm Staging ; Neoplasms/*DIAGNOSIS ; Nephroblastoma/DIAGNOSIS/PATHOLOGY ; Neuroblastoma/DIAGNOSIS/ PATHOLOGY ; Nuclear Magnetic Resonance/*DIAGNOSTIC USE ; Sarcoma, Ewing's/DIAGNOSIS ; Sarcoma, Osteogenic/DIAGNOSIS ; Soft Tissue Neoplasms/DIAGNOSIS ; Teratoma/DIAGNOSIS/PATHOLOGY ; Tomography, X-Ray Computed SO - Arch Surg 1986 May;121(5):522-9 6 UI - 86189499 AU - Gabius HJ ; Engelhardt R ; Sartoris DJ ; Cramer F TI - Pattern of endogenous lectins of a human sarcoma (Ewing's sarcoma) reveals differences to human normal tissues and tumors of epithelial and germ cell origin. AB - A human sarcoma, Ewing's sarcoma, contains activities of endogenous lectins. Fractionation of salt and detergent extracts by affinity chromatography on columns with immobilized sugars or glycoproteins results in the pattern of endogenous lectins for alpha- and beta-galactosides, alpha-mannosyl- and alpha-fucosyl-moieties. Whereas some lectins are known from normal, non-malignant human tissues or from a human epithelial tumor or a human germ cell tumor, a Ca2+-independent alpha- and beta-galactoside-binding protein at apparent molecular weight of 58 kilodaltons has so far not been characterized from any human source. The patterns for the tumors and human normal tissues reveal various differences in comparison between each other. These differences, documented for the first human sarcoma, human tumors of different histogenetic lineage and normal tissues are a first step to a lectin-based diagnosis and therapy of certain human cancer types. MH - Apudoma/ANALYSIS ; Bone Marrow/ANALYSIS ; Chromatography, Affinity ; Comparative Study ; Electrophoresis, Polyacrylamide Gel ; Human ; Lectins/*ANALYSIS ; Molecular Weight ; Sarcoma, Ewing's/*ANALYSIS ; Teratoma/ANALYSIS SO - Cancer Lett 1986 May;31(2):139-45