==================================CMR16==================================
16.  Articles on the agent 'Evans Blue' describing clinical uses of this
     dye, the manner and amounts in which it is given to patients, or 
     experimental animals, the pharmacokinetics, distribution, metabolism,
     and elimination, and particularly, the spectral properties (light
     absorption and emission as a function of wavelength).
1
UI  - 87008844
AU  - Gardner MJ
TI  - Micromethod for the analysis of evans blue in plasma using
      ion-pair high-performance liquid chromatography.
AB  - A micromethod for the determination of Evans Blue in plasma has
      been developed. Effective release of the dye from the dye-albumin
      complex was accomplished using a solution of urea and
      2-mercaptoethanol. Ion-pairing techniques were used to extract
      the dye as well as the internal standard (Naphthol Blue Black B)
      from plasma. Separation involved ion-pair high-performance liquid
      chromatography. Eluent was monitored at 605 nm. The technique
      results in a linear response over the concentration range of
      approximately 1.0-30.0 micrograms/ml. Assay performance was
      verified by estimating plasma volume in the rat.
MH  - Animal ; Azo Compounds/*DIAGNOSTIC USE ; Chromatography, High
      Pressure Liquid ; Drug Stability ; Evans Blue/*DIAGNOSTIC USE ;
      Female ; Human ; Indicators and Reagents ; Microchemistry ; Rats
      ; Rats, Inbred Strains
SO  - J Chromatogr 1986 Sep 5;381(2):295-303
2
UI  - 86215215
AU  - Balzarini J ; Mitsuya H ; De Clercq E ; Broder S
TI  - Aurintricarboxylic acid and Evans Blue represent two different
      classes of anionic compounds which selectively inhibit the
      cytopathogenicity of human T-cell lymphotropic virus type
      III/lymphadenopathy-associated virus.
AB  - Aurintricarboxylic acid, an anionic triphenylmethane dye, and
      Evans Blue, an anionic compound structurally related to suramin,
      are, like suramin itself, inhibitors of human T-cell lymphotropic
      virus type III (HTLV-III)/-lymphadenopathy-associated virus (LAV)
      in vitro. These compounds may be targeted, at least in part, at
      the HTLV-III/LAV reverse transcriptase. The lack of any
      appreciable cytostatic action of aurintricarboxylic acid, Evans
      Blue and suramin against several murine and human cell lines,
      their inability to inhibit cellular DNA, RNA and protein
      synthesis, and their high lethal dose-50 (greater than or equal
      to 0.340 g/kg) for NMRI mice point to the selectivity of the
      compounds as inhibitors of HTLV-III/LAV.
MH  - Animal ; Aurintricarboxylic Acid/*PHARMACODYNAMICS/TOXICITY ; Azo
      Compounds/*PHARMACODYNAMICS ; Benzhydryl Compounds/
      PHARMACODYNAMICS/TOXICITY ; Cell Division/DRUG EFFECTS ;
      Cyclohexanecarboxylic Acids/*PHARMACODYNAMICS ; Cytopathogenic
      Effect, Viral/DRUG EFFECTS ; Erythroleukemia/PATHOLOGY ; Evans
      Blue/*PHARMACODYNAMICS/TOXICITY ; Human T-Cell Leukemia Virus/
      *DRUG EFFECTS ; Injections, Intraperitoneal ; Leukemia L1210/
      PATHOLOGY ; Mammary Neoplasms, Experimental/ULTRASTRUCTURE ; Mice
      ; Support, Non-U.S. Gov't ; Suramin/PHARMACODYNAMICS/TOXICITY ;
      Viral Proteins/BIOSYNTHESIS
SO  - Biochem Biophys Res Commun 1986 Apr 14;136(1):64-71