==================================CMR13==================================
13.  Use of phenylephrine nasal spray and an MAO inhibitor for the treatment
     of orthostatic hypotension.
1
UI  - 86199501
AU  - Fowler CJ ; O'Carroll AM ; Court JA ; Candy JM
TI  - Stimulation by noradrenaline of inositol phospholipid breakdown
      in the rat hippocampus: effect of the ambient potassium
      concentration.
AB  - The stimulation by noradrenaline (NA) of inositol phospholipid
      (PI) breakdown has been studied using rat hippocampal miniprisms.
      Pretreatment with the monoamine oxidase inhibitor, pargyline,
      potentiated the stimulation produced by NA. On the other hand,
      pargyline pretreatment did not affect the stimulation of PI
      breakdown by the alpha 1-adrenoceptor agonist phenylephrine. NA-
      and phenylephrine-stimulated PI breakdown were enhanced by
      increasing the ambient potassium concentration in the assay from
      5.88 to 18.2 mM. This enhancement did not, in the case of NA,
      change either the EC50 value for this agonist (2-3 microM) or the
      pA2 value for the competitive antagonism of the stimulation by
      the alpha 1-antagonist prazosin (pA2 value 9.2). Time-courses of
      the NA-stimulated PI turnover in different brain regions
      indicated that the rate of stimulation was in the order frontal
      cortex greater than hypothalamus greater than or equal to
      hippocampus much greater than cerebellum.
MH  - Animal ; Biotransformation ; Carbachol/PHARMACODYNAMICS ;
      Cerebellum/METABOLISM ; Cerebral Cortex/METABOLISM ; Dioxanes/
      METABOLISM ; Hippocampus/DRUG EFFECTS/*METABOLISM ; Hypothalamus/
      METABOLISM ; In Vitro ; Male ; Norepinephrine/*PHARMACODYNAMICS ;
      Pargyline/PHARMACODYNAMICS ; Phenylephrine/PHARMACODYNAMICS ;
      Phosphoinositides/*METABOLISM ; Potassium/*PHYSIOLOGY ; Prazosin/
      PHARMACODYNAMICS ; Rats ; Rats, Inbred Strains ; Support,
      Non-U.S. Gov't
SO  - J Pharm Pharmacol 1986 Mar;38(3):201-8