==================================CMR08==================================
8.   Key word -  Flip-Flop or Flip-Flop Phenomenon.
     Seizures which electroencephalographically seem to
     begin in one hemisphere, then seem to shift to the other
     hemisphere.
1
UI  - 87088831
AU  - Arima T ; Segawa T ; Nomura Y
TI  - Influence of pertussis toxin on the effects of guanine nucleotide
      on adenylate cyclase in rat striatal membranes.
AB  - The influence of pertussis toxin on the effects of guanine
      nucleotide on adenylate cyclase activity were investigated in rat
      striatal membranes. GTP promoted and inhibited the activity at 1
      and 100 microM, respectively. The inhibitory effects of GTP were
      abolished by pretreatment of the membranes with pertussis toxin.
      GppNHp (guanyl-5'-y1-beta,gamma-imidodiphosphate) exerted only
      stimulatory effects and pertussis toxin did not affect the
      effects of GppNHp. GDP at 10 and 100 microM caused significant
      inhibition which was completely suppressed by pertussis toxin. It
      is suggested that guanine nucleotide regulates the affinity of as
      in stimulatory GTP-binding regulatory protein to either beta
      gamma or catalytic units of adenylate cyclase in a flip-flop
      manner. Inhibitory GTP-binding regulatory protein seems to play a
      regulatory role in inhibiting alpha s activity supplying the beta
      gamma heterodimer.
MH  - Adenyl Cyclase/*METABOLISM ; Animal ; Cell Membrane/METABOLISM ;
      Corpus Striatum/*METABOLISM ; Guanine Nucleotide Regulatory
      Protein/METABOLISM ; Guanine Nucleotides/*PHARMACODYNAMICS ;
      Macromolecular Systems ; Pertussis Toxins/*PHARMACODYNAMICS ;
      Rats ; Receptors, Dopamine/*DRUG EFFECTS ; Support, Non-U.S.
      Gov't
SO  - Life Sci 1986 Dec 22;39(25):2429-34
2
UI  - 87028966
AU  - Shih WJ ; DeLand FH ; Domstad PA
TI  - Flip-flop phenomenon in radiohippuran renal imaging. A sign of
      obstructive nephropathy.
AB  - In the dynamic radionuclide brain study, decreased flow in one
      cerebral hemisphere during the arterial phase followed by
      relatively increased radioactivity as compared with the
      contralateral hemisphere has been termed the flip-flop
      phenomenon, and reflects the development of collateral
      circulation to the affected side. In I-131 Hippuran renal
      imaging, relatively decreased activity in one kidney frequently
      is observed during the initial phase of the study, and is
      followed by a gradual increase of radioactivity in the late
      images when compared with the contralateral kidney. To evaluate
      the significance of this renal flip-flop phenomenon, the studies
      from 23 patients with these findings were retrospectively
      compared with the clinical data and findings from other
      diagnostic studies (CT, ultrasound, intravenous pyelogram,
      autopsy). Partial obstruction of the renal collecting system was
      found in all 23 patients. The causes were various malignant
      tumors in nine patients (colonic carcinoma, three patients;
      transitional cell carcinoma, three patients; prostatic carcinoma,
      two patients; seminoma, one patient), ureteropelvic obstruction
      in three patients, papillary necrosis in one patient, and
      ureteral fibrosis in one patient. The flip-flop phenomenon
      reflects asymmetric renal tubular function with decrease
      (prolonged parenchymal transit time) in the affected kidney as a
      result of ipsilateral obstruction of the collecting system, while
      contralateral renal function remains normal or relatively normal.
      The presence of the flip-flop phenomenon in an I-131 Hippuran
      renal study suggests the existence of some degree of collecting
      system obstruction that has persisted long enough to result in
      renal parenchymal damage.
MH  - Comparative Study ; DTPA/DIAGNOSTIC USE ; Human ; Iodohippuric
      Acid/*DIAGNOSTIC USE ; Kidney Diseases/*RADIONUCLIDE IMAGING ;
      Kidney Neoplasms/RADIONUCLIDE IMAGING ; Kidney Papillary Necrosis/
      RADIONUCLIDE IMAGING ; *Radioisotope Renography ; Technetium/
      DIAGNOSTIC USE ; Tomography, X-Ray Computed ; Ultrasonic
      Diagnosis ; Ureteral Diseases/RADIONUCLIDE IMAGING ; Ureteral
      Obstruction/RADIONUCLIDE IMAGING ; Urography
SO  - Clin Nucl Med 1986 Oct;11(10):707-12
3
UI  - 86162622
AU  - Verreault J ; C:ot:e C
TI  - Flip-flop phenomenon and dissection of extracranial carotid
      artery.
AB  - A case of extracranial carotid artery dissection investigated
      both by conventional brain imaging and by arteriography is
      presented. The radionuclide angiogram showed a flip-flop
      phenomenon on the left hemisphere. The implications, including
      clinical features, pathogenesis, diagnosis, and treatment are
      discussed. Dissection of extracranial carotid artery is a cause
      of carotid hypoactivity, and this phenomenon is associated
      directly with a flip-flop phenomenon on brain imaging.
MH  - Aneurysm, Dissecting/*DIAGNOSIS/RADIOGRAPHY/RADIONUCLIDE IMAGING
      ; Carotid Artery Diseases/*DIAGNOSIS/RADIOGRAPHY/RADIONUCLIDE
      IMAGING ; Carotid Artery, External ; Case Report ; Cerebral
      Angiography ; Human ; Male ; Middle Age ; Sugar Acids/DIAGNOSTIC
      USE ; Technetium/DIAGNOSTIC USE
SO  - Clin Nucl Med 1986 Apr;11(4):251-3
4
UI  - 86112699
AU  - McCormack J ; Peyster RG ; Brodner RA ; Cooper VR
TI  - CT visualization of ruptured berry aneurysm within hematoma: the
      flip-flop sign.
AB  - Postcontrast CT of the head may be a useful screening technique
      for identifying an aneurysm within an intracerebral hematoma.
      This could avoid unnecessary angiography with its attendant
      morbidity in inoperable situations and obviate initial
      arteriography in patients whose surgery is to be delayed.
MH  - Adult ; Case Report ; Cerebral Aneurysm/*RADIOGRAPHY ; Cerebral
      Hemorrhage/*RADIOGRAPHY ; Hematoma/*RADIOGRAPHY ; Human ; Male ;
      Middle Age ; Rupture, Spontaneous ; *Tomography, X-Ray Computed
SO  - J Comput Assist Tomogr 1986 Jan-Feb;10(1):28-31