Y015154 1 
1808026 86025026
In situ actin distribution in excised retrolental membranes in retinopathy of prematurity.
Soong HK; Eller AW; Tirose T; Hanninen L; Kenyon KR
Dept. of Ophthalmology, Univ. of Michigan School of Medicine, Ann Arbor 48105.
Arch Ophthalmol (US), Oct 1985, 103 (10) p1553-6,
ISSN 0003-9950
Jrnl Code: 830 
Contract/Grant No.: EY-05649; EY-03967
Lang.: ENG.
Jrnl Ann.: 8601
Subfile: AIM; INDEX MEDICUS
Actin, an intracellular contractile protein, is associated with cell movements in both muscle and nonmuscle tissues. Using the fluorescent derivative of the mushroom toxin, phallacidin, which specifically binds to polymerized (filamentous) actin, we demonstrated the distribution of actin in retrolental membranes excised during open-sky vitrectomy from six infants with leukokoria due to retrolental fibroplasia. Actin was detected in ubiguitous linear bundles, which is consistent with the existence of contractile forces. Actin was also concentrated in the cortical cytoplasm of cells, thus outlining the plasma membranes. Transmission electron microscopy has identified many of these cells to be myofibroblastlike in appearance. Myofibroblasts are known to contract like smooth-muscle cells and have been reported as the putative causal factor in the contraction of scars and transvitreal membranes.
Tags: Human; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.
Desc.: *Actins--Metabolism (ME); *Eye--Metabolism (ME); Histocytochemistry; Infant; Membranes--Metabolism (ME); Membranes--Pathology (PA); Membranes--Ultrastructure (UL); Microscopy, Electron; Microscopy, Fluorescence; *Retinal Diseases--Metabolism (ME); Retinal Diseases--Pathology (PA); Tissue Distribution

Y015154 2 
1798485 86015485
Computed tomography of the nonrhegmatogenous retinal detachment in the pediatric patient.
Haik BG; Saint Louis L; Smith ME; Abramson DH; Ellsworth RM
Dept. of Ophthalmology, Cornell Univ. Medical College, New York Hospital, Memorial Sloan-Kettering Cancer Center, New York.
Ophthalmology (US), Aug 1985, 92 (8) p1133-42,
ISSN 016?-6420
Jrnl Code: OI5
Lang.: ENG.
Jrnl Ann.: 8601
Subfile: INDEX MEDICUS
Nonrhegmatogenous retinal detachments occur in the pediatric population secondary to other ocular disorders. The most important cause to identify is retinoblastoma. Computed tomography has proven to be the most reliable ancillary diagnostic test in this pediatric population. A series of eighty patients, presenting with nonrhegmatogenous retinal detachments, was examined. The role of computed tomography and characteristic clinical findings are discussed.
Tags: Human; Male; Support, Non-U.S. Gov't
Desc.: Child; Child, Preschool; Choroid--Abnormalities (AB); Coloboma--Complications (CO); Eye Diseases--Complications (CO); Eye Neoplasms--Complications (CO); Hemangioma--Complications (CO); Infant; Infant, Newborn; Retinal Detachment--Etiology (ET); *Retinal Detachment--Radiography (RA); Retinal Diseases--Complications (CO); Retinal Hemorrhage--Complications (CO); Retinoblastoia--Complications (CO); Retrolental Fibroplasia--Complications (CO); *Tomography, X-Ray Computed; Toxocariasis--Complications (CO); Vitreous Body--Pathology (PA)

Y015154 3
1798467 86015467
Vitamin E and retinopathy of prematurity. Follow-up at one year.
Schaffer DB; Johnson L; Quinn GE; Weston M; Bowen FW Jr
Dept. of Pediatrics, Univ. of Pennsylvania School of Medicine, Philadelphia.
Ophthalmology (US), Aug 1985, 92 (8) p1005-11
ISSN 0161-6420
Jrnl Code: OI5
Contract/Grant No.: R01EY01723
Lang.: ENG.
Jrnl Ann.: 8601
Subfile: INDEX MEDICUS
Five hundred forty-five infants weighing less than 1501 g at birth were entered into a randomized, prospective study to determine the effect of high serum levels (5 mg/dL) of vitamin E used prophylactically to try to prevent or alter the natural course of retinopathy of prematurity (ROP) and its sequel, retrolental fibroplasia (RLF). Three hundred twenty-eight infants were available for the one- to two-year eye examination. Although there was a trend (P = 0.07) toward less severe RLF among vitamin E-treated infants, the incidence of RLF was 11/162 (6.8%) in the placebo treated (P) infants, and 12/166 (7.2%) in the vitamin E-treated (E) infants. The incidences of hyperopia, myopia, anisometropia, strabismus and amblyopia were also similar in both the P and E groups.
Tags: Comparative Study; Human; Support, U.S. Gov't, P.H.S.
Desc.: Cicatrix--Complications (CO); Clinical Trials; Eye Diseases--Occurrence (OC); Follow-Up Studies; Infant; Infant, Low Birth Weight; Infant, Premature, Diseases--Drug Therapy (DT); Infant, Premature, Diseases--Occurrence (OC); *Infant, Premature, Diseases--Prevention and Control (PC); Prospective Studies; Random Allocation; Refractive Errors--Classification (CL); Retinal Diseases--Complications (CO); Retinal Diseases--Drug Therapy (DT); Retinal Diseases--Occurrence (OC); *Retinal Diseases--Prevention and Control (PC); Retrolental Fibroplasia--Prevention and Control (PC); Vitamin E--Blood (BL); *Vitamin E--Therapeutic Use (TU)
CAS Registry No.: 1406-18-4 (Vitamin E)

Y015154 4
1790567 86007567
Retinopathy of prematurity: a risk factor analysis with univariate and multivariate statistics.
Bossi E; Koerner F; Flury B; Zulauf M
Division of Neonatology, Univ. Children's Hospital, Berne, Switzerland.
Helv Paediatr Acta (SWITZERLAND), Oct 1984, 39 (4) p307-17,
ISSN 0018-022X
Jrnl Code: G59
Lang.: ENG.
Jrnl Ann.: 8601
Subfile: INDEX MEDICUS
Seventy-three out of 639 ophthalmoscopically examined newborns (11.4%) showed varying degrees of retinopathy of prematurity (ROP). Three infants were blind (0.5%). Sixty-six patients were matched with controls according to gestational age, birth weight, birth date and neonatal unit. Using univariate statistics, the variables representing the extent of O2-exposure, elevated paO2, elevated paCO2, paCO2-fluctuations, acidosis, blood transfusions, and artificial ventilation were found to be significantly associated with ROP. In contrast, the variables representing hypocapnia, Hb-levels, parenteral fluid administration and fluid retention showed no correlation with ROP. When a multivariate statistical method was used, the variables representing gestational age, elevated paO2, elevated paCO2 and paCO2-fluctuations as well as the ones defining blood transfusions lost their association with ROP. Episodes of acidosis, multiple birth, birth weight, total hours with Fio2 greater than 0.4, and total duration of artificial ventilation remained in the regression, and hypocapnia gained a significant negative correlation with ROP. This comparative survey based on univariate and multivariate statistics demonstrates that significance levels of identically defined biological and therapeutic variables obtained from the same population of patients are to be interpreted with caution. This fact may also explain contrasting opinions on risk factors in the literature. Multivariate statistical analyses are useful for a relative comparison of significance within a given set of variables. Conclusions on a possible causal relationship as well as on prophylactic measures are not possible.
Tags: Comparative Study; Human
Desc.: Infant, Newborn; *Infant, Premature, Diseases--Etiology (ET) ; Regression Analysis; *Retrolental Fibroplasia--Etiology (ET); Retrospective Studies; Risk; Statistics

Y015154 5
1780854 85305854
Retinopathy of prematurity: incidence and treatment.
Reisner SH; Amir J; Shohat M; Krikler R; Nissenkorn I; Ben-Sira I
Neonatal Dept., Beilinon Medical Centre, Israel.
Arch Dis Child (ENGLAND), Aug 1985, 60 (8) p698-701,
ISSN 0003-9888
Jrnl Code: 6XG
Lang.: ENG.
Jrnl Ann.: 8512
Subfile: AIM; INDEX MEDICUS
The incidence of retinopath of prematurity in infants with a birthweight less than or equal to 2500 g admitted to a tertiary neonatal intensive care unit between 1977 and 1983 was 20% of all survivors. There was a reciprocal relation between birthweight and the incidence of the disease, with an incidence of 68% in infants weighing less than or equal to 1000 g at birth. Cryotherapy of the avascular retina was performed if the acute disease progressed rapidly during stage 3 and the amount of fibrovascular proliferation was mild to moderate with signs of plus disease (presence of appreciable posterior pole vascular tortuosity and dilatation and the presence of engorgement of iris vessels). This method of treatment was performed in 4% of all survivors: in 26% of infants weighing less than or equal to 1000 g at birth and 5% of infants weighing 1001-1500 g. No infants had cicatricial disease greater than stage 2 on follow-up. The absence of any severe cicatricial disease or blindness in this large group of high risk infants suggests that when indicated and performed on the avascular retina cryotherapy may be an important method of treatment.
Tags: Human
Desc.: Acute Disease; Birth Weight; *Cryosurgery; Follow-Up Studies ; Infant, Low Birth Weight; INFANT LBW; Infant, Newborn; Israel; Retrolental Fibroplasia--Occurrence (OC); *Retrolental Fibroplasia--Surgery (SU)

Y015154 6
1772568 85297568
Risk factors for retrolental fibroplasia: experience with 3, 025 premature infants. National Collaborative Study on Patent Ductus Arteriosus in Premature Infants.
Purohit DM; Ellison RC; Zierler S; Miettinen OS; Nadas AS
Dept. of Pediatrics, Medical Univ. of South Carolina, Charleston 2425.
Pediatrics (US), Sep 1985, 76 (3) p339-44,
ISSN 0031-4005
Jrnl Code: OXV
Contract/Grant No.: HL23121
Lang.: ENG.
Jrnl Ann.: 8512
Subfile: AIM; INDEX MEDICUS
The rate of retrolental fibroplasia in relation to prenatal and neonatal characteristics was explored on the basis of a cohort of 3, 025 neonates with birth weight less than 1, 750 g. The overall rate of retrolental fibroplasia of any degree at hospital discharge was 11%, varying from 43% for those with birth weight between 500 and 749 g to 3% for those in the 1, 500- to 1, 750-g category. Among the potential determinants, the main interest was in nonhyperoxic characteristics, conditional on measures of prematurity and oxygen supplementation. Maternal diabetes and antihistamine use during the last 2 weeks of pregnancy were associated with significantly higher rates of retrolental fibroplasia, whereas toxemia was associated with lower rates. Frequent apneic spells, bronchopulmonary dysplasia, and sepsis in the neonate were also associated with significantly higher rates.
On the other hand, the data indicate no independent role of low Apgar score, intraventricular hemorrhage, exchange transfusion, patent ductus arteriosus, of certain other characteristics previously postulated as risk factors.
Tags: Female; Human; Support, U.S. Gov't, P.H.S.
Desc.: Anemia--Complications (CO); Apnea--Complications (CO); Birth Weight; Bronchopulmonary Dysplasia--Complications (CO); Histamine H1 Receptor Blockaders--Adverse Effects (AE); RECEPT BLOCK H1--Adverse Effects (AE); Infant, Low Birth Weight; INFANT LBW; Infant, Newborn; Infant, Premature, Diseases--Etiology (ET); *Infant, Premature, Diseases--Occurrence (OC); Infection--Complications (CO); Pregnancy in Diabetes--Complications (CO); PREGN IN DIABETES--Complications (CO); Pregnancy Complications, Hematologic; PREGN COMPL HEMATOL; Pregnancy Toxemias--Complications (CO); PREGN TOXEMIAS--Complications (CO); Pregnancy ; PREGN; Retrolental Fibroplasia--Etiology (ET); *Retrolental Fibroplasia--Occurrence (OC); Risk; United States

Y015154 7
1762408 85287408
Physiological and therapeutic role of vitamin E in humans: an update.
Moudgil KD; Narang BS
Indian J Pediatr (INDIA) Nov-Dec 1984, 51 (413) p715-24,
ISSN 0019-5456
Jrnl Code: GKT
Lang.: ENG.
Jrnl Ann.: 8512
Subfile: INDEX MEDICUS
Tags: Animal; Female; Human; Male
Desc.: Adult; Aging; Anthropoidea; Antioxida?ts--Metabolism (ME); Bronchopulmonary Dysplasia--Prevention and Control (PC); Cardiovascular System--Physiology (PH); Chemistry; Child; Guinea Pigs; Hamsters; Hematopoietic System--Physiology (PH); Infant, Newborn; Mice; Muscular Dystrophy--Prevention and Control (PC); Neurons--Physiology (PH); Rabbits; Rats; Reproduction; Retrolental Fibroplasia--Prevention and Control (PC); Swine; Vitamin E--Metabolism (ME); *Vitamin E--Physiology (PH); Vitamin E--Therapeutic Use (TU)
CAS Registry No.: 1406-18-4 (Vitamin E)

Y015154 8
1750733 85275733
[Effects of vitamin E deficiency on oxygen induced retinopathy in the rat]
Yabe H
Nippon Ganka Gakkai Zasshi (JAPAN), Apr 1985, 89 (4) p624-30,
ISSN 0029-0203
Jrnl Code: 22O
Lang.: JAPANESE
Summary Lang.: ENG.
Doc. Type: English Abstract
Jrnl Ann.: 8511
Subfile: INDEX MEDICUS
Tags: Animal; Support, Non-U.S. Gov't
Desc.: Rats; Rats, Inbred Strains; *Retrolental Fibroplasia--Etiology (ET); *Vitamin E Deficiency--Complications (CO)

Y015154 9
1748801 85273801
Ophthalmic findings in very low birth weight children.
Hammer HM; Noble BA; Harcourt RB; Congdon PJ
Dept. of Ophthalmology, General Infirmary, Leeds
Trans Ophthalmol Soc UK (ENGLAND), 1985, 104 ( Pt 3) p329-31,
ISSN 0078-5334
Jrnl Code: WA1
Lang.: ENG.
Jrnl Ann.: 8511
Subfile: INDEX MEDICUS
Recent advances in neonatal intensive care have led to a much improved survival rate in very low birth weight infants (under 1, 500 g). A group of such children was examined and found to have a low incidence of serious visual or general handicap, but severe retrolental fibroplasia (RLF) affects a significant number.
Tags: Case Report; Female; Human; Male
Desc.: *Eye Diseases--Occurrence (OC); Eye Movements; *Infant, Low Birth Weight; *INFANT LBW; Infant, Newborn; Nystagmus--Occurrence (OC); Retrolental Fibroplasia--Occurrence (OC); Strabismus--Occurrence (OC)

Y015154 10
1744506 85269506
Vitamin E and the prevention of retinopathy of prematurity. Committee on Fetus and Newborn.
Pediatrics (US), Aug 1985, 76 (2) p315-6,
ISSN 0031-4005
Jrnl Code: OXV
Lang.: ENG.
Jrnl Ann.: 8511
Subfile: AIM; INDEX MEDICUS
Tags: Human
Desc.: Clinical Trials; Infant, Low Birth Weight; INFANT LBW; Infant, Newborn; *Retrolental Fibroplasia--Prevention and Control (PC); Risk; *Vitamin E--Therapeutic Use (TU)
CAS Registry No.: 1406-18-4 (Vitamin E)

Y015154 11
1742916 85267916
Hazards to vision in the nursery [editorial]
Sisson TR
N Engl J Med (US), Aug 15 1985, 313 (7) p444-5,
ISSN 0028-4793
Jrnl Code: ?NOW
Lang.: ENG.
Jrnl Ann.: 8511
Subfile: AIM; INDEX MEDICUS
Tags: Human
Desc.: Infant, Newborn; *Infant, Premature, Diseases--Etiology (ET) ; *Intensive Care Units, Neonatal; *Lighting--Adverse Effects (AE); *Nurseries, Hospital; Retrolental Fibroplasia--Etiology (ET); *Vision Disorders--Etiology (ET)

Y015154 12
1742908 85267908
Effect of bright light in the hospital nursery on the incidence of retinopathy of prematurity.
Class P; Avery GB; Subramanian KN; Keys MP; Sostek AM; Friendly DS
Dept. of Psychology, George Washington Univ., Washington, D.C.
N Engl J Med (US), Aug 15 1985, 313 (7) p401-4,
ISSN 0028-4793
Jrnl Code: NOW
Lang.: ENG.
Jrnl Ann.: 8511
Subfile: AIM; INDEX MEDICUS
The preterm infant is subjected to prolonged exposure to ambient nursery illumination at levels that have been found to produce retinal damage in animals. We prospectively investigated the effect of exposure to light in two intensive care nurseries by comparing the incidence of retinopathy of prematurity among 74 infants from the standard bright nursery environment (median light level, 60 foot-candles [ftc]) with the incidence among 154 infants of similar birth weight for whom the light levels were reduced (median, 25 ftc). There was a higher incidence of retinopathy of prematurity in the group of infants who had been exposed to the brighter nursery lights, particularly in those with birth weight below 1000 g (86 percent vs. 54 per cent, P less than 0.01 by chi-square test). We conclude that the high level of ambient illumination commonly found in the hospital nursery may be one factor contributing to retinopathy of prematurity and that safety standards with regard to current lighting practices should be reassessed.
Tags: Female; Human; Male; Support, Non-U.S. Gov't
Desc.: Birth Weight; District of Columbia; Gestational Age; Hospital Bed Capacity, 100 to 299; HOSP BED CAPAC 100; Hospital Bed Capacity, 300 to 499; HOSP BED CAPAC 300; Infant Newborn; *Intensive Care Units, Neonatal; Intensive Care Units, Neonatal--Standards (ST); *Lighting--Adverse Effects (AE); *Nurseries, Hospital; Nurseries, Hospital--Standards (ST); Prospective Studies; *Retrolental Fibroplasia--Etiology (ET); Retrolental Fibroplasia--Occurrence (OC)

Y015154 13
1727632 85252632
Retinopathy of prematurity: review of a four-year period.
Cats BP; Tan KE
Univ. Children's Hospital, Utrecht, The Netherlands.
Br J Ophthalmol (ENGLAND), Jul 1985, 69 (7) p500-3,
ISSN 0007-1161
Jrnl Code: AZK
Lang.: ENG.
Jrnl Ann.: 8511
Subfile: INDEX MEDICUS
For a four-year period the development of retinopathy of prematurity (ROP) was determined among neonates considered at risk of acquiring this condition. Fifty-six out of 249 premature infants developed some degree of ROP. Comparison of these infants with a group of 56 controls, admitted to hospital in the same period and matched for sex, birth weight, and gestational age, showed significant differences for sepsis, blood transfusions, and the period of oxygen monitoring in relation to the period of oxygen administration. The most consistent factor associated with the development of ROP was gestational age at the time of birth, though no gestational age group was entirely devoid of ROP. This suggests that screening for ROP should not be restricted to high-risk premature infants only.
Tags: Female; Human; Male
Desc.: Blood Transfusion; Gestational Age; Infant, Newborn; Oxygen--Therapeutic Use (TU); Respiration, Artificial; *Retrolental Fibroplasia--Etiology (ET); Risk
CAS Registry No.: 7782-44-7 (Oxygen)

Y015154 14
1726221 85251221
Retinopathy of prematurity [letter]
Hindle NW
Arch Ophthalmol (US), Jul 1985, 103 (7) p894-5,
ISSN 0003-9950
Jrnl Code: 830
Lang.: ENG.
Jrnl Ann.: 8510
Subfile: AIM; INDEX MEDICUS
Tags: Human
Desc.: Infant, Newborn; *Infant, Premature; *Retinal Diseases--Classification (CL); Retrolental Fibroplasia--Prevention and Control (PC)

Y015154 15
1723718 85248718
Observations on the retinopathy of prematurity.
Patz A
Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Baltimore, MD 21205.
Am J Ophthalmol (US), Jul 15 1985, 100 (1) p164-8,
ISSN 0002-9394
Jrnl Code: ?OQ
Lang.: ENG.
Jrnl Ann.: 8510
Subfile: AIM; INDEX MEDICUS
The fourfold to fivefold increased survival rate since 1950 of premature infants with birthweights of less than 1, 000 g apparently explains the increase in cases of retinopathy of prematurity in recent years. A new international classification permits standardized grading of the retinopathy of prematurity based on severity, anterior-posterior location, and the meridians involved. Previously reported clinical trials on the role of vitamin E in the prevention of retinopathy of prematurity have given conflicting results.
Tags: Human
Desc.: Carbon Dioxide--Blood (BL); Infant, Newborn; Infant, Premature, Diseases--Classification (CL); *Infant, Premature, Diseases--Etiology (ET); Infant, Premature, Diseases--Prevention and Control (PC); Oxygen--Blood (BL); Retina--Pathology (PA); Retinal Detachment--Etiology (ET); Retinal Diseases--Classification (CL); *Retinal Diseases--Etiology (ET); Retinal Diseases--Prevention and Control (PC); Retrolental Fibroplasia--Etiology (ET); Vitamin E--Therapeutic Use (TU)
CAS Registry No.: 1406-18-4 (Vitamin E); 7782-44-7 (Oxygen)

Y015154 16
1716573 85241573
[Prevention of retinopathy of premature infants with D-penicillamine]
A koraszulottek retinopathiajanak megelozese D-penicillaminnal
Lakatos L; Hatvani I; Oroszlan G; Balla G; Karmazsin L; Olubunmi A; Kincses E; Szabo I; Vekerdy Z
Orv Hetil (HUNGARY), Jun 9 1985, 126 (23) p1391-6,
ISSN 0030-6002
Jrnl Code: OL8
Lang.: HUNGARIAN
Summary Lang.: ENG. Doc. Type: Eng. Abst.
Jrnl Ann.: 8510
Subfile: INDEX MEDICUS
Tags: Human
Desc.: Clinical Trials; Gestational Age; Infant, Low Birth Weight; INFANT LBW; Infant, Newborn; *Infant, Newborn, Diseases--Prevention and Control (PC); *Penicillamine--Therapeutic Use (TU); Prospective Studies; *Retinal Diseases--Prevention and Control (PC); *Retrolental Fibroplasia--Prevention and Control (PC)
CAS Registry No.: 52-67-5 (Penicillamine)

Y015154 17
1712855 85237855
Early intervention aids vision-impaired infants [news]
Cole H
JAMA (US), Aug 2 1985, 254 (5) p595,
ISSN 0098-7484
Jrnl Code: KFR Lang.: ENG.
Jrnl Ann.: 8510
Subfile: AIM; INDEX MEDICUS
Tags: Human
Desc.: Infant; *Retinal Detachment--Surgery (SU); *Retrolental Fibroplasia--Surgery (SU)

Y015154 18
1708789 85233789
Postnatal retinal vascular development of the puppy.
Flower RW; McLeod DS; Lutty GA; Goldberg B; Wajer SD
Wilmer Ophthalmological Institute, Johns Hopkins Hospital and Univ., Baltimore, Maryland.
Invest Ophthalmol Vis Sci (US), Jul 1985, 26 (7) p957-68,
ISSN 0146-0404
Jrnl Code: GWI
Contract/Grant No.: EY-02482 Lang.: ENG.
Jrnl Ann.: 8510
Subfile: INDEX MEDICUS
Retinal vascular development during the first three postnatal weeks was studied in 63 purebred beagle puppies. Use of a positive enzyme histochemical reaction for adenosine triphosphatase in the nuclei and nucleoli of vascular cells made visualization of the retinal vasculature possible. Animals were killed by decapitation. Thus, artifacts resulting from use of anesthetics or tracer substances were avoided. In general, this study demonstrates important similarities between canine and human retinal vascular development, and this gives further reason to use of the puppy retina as a superior model for studying retrolental fibroplasia pathogenesis. This staining technique demonstrates undifferentiated cells in the avascular retina that appear to be vascular precursors or angioblasts. Primordial vessels form by organization of differentiating angioblasts that exist in peripheral retinal cystic spaces at birth, or by addition of fully differentiated endothelium; they form unlike neovascularization. Muller cell processes appear to provide a structural matrix throughout the avascular puppy retina on which differentiated angioblasts organize into a vascular network. Arteries develop in beds of primordial capillaries lying near the leading edge of the developing vasculature. This precedes vein formation which occurs through a process involving coalescence of embryonic capillaries which themselves were derived from primordial capillaries. Preliminary examination of eight mongrel kitten retinas prepared by this method clearly indicates that the puppy retina is much more completely vascularized at birth than that of the newborn kitten. Moreover, the rate of postnatal retinal vascularization is significantly faster in the kitten. The kitten vasculature does appear to form by the organization of angioblasts as in the puppy, but kitten angioblasts have a different appearance from those in the puppy.
Tags: Animal; Support, U.S. Gov't, Non-P.H.S.; Support, U.S. Gov't, P.H.S.
Desc.: Adenosine Triphosphatase--Metabolism (ME); Animals, Newborn Capillaries--Cytology (CY); *Cell Differentiation; Cell Nucleus--Ultrastructure (UL); Dogs; Endothelium--Cytology (CY); *Retinal Artery--Cytology (CY); Retinal Ganglion Cells--Cytology (CY); *Retinal Vein--Cytology (CY)
Enzyme No.: EC 3.6.1.3 (Adenosine Triphosphatase)

Y015154 19
1695164 85220164
An international classification of retinopathy of prematurity: clinical experience.
Flynn JT
Dept. of Ophthalmology, Bascom Palmer Eye Institute, Univ. of Miami School of Medicine, Florida.
Trans Am Ophthalmol Soc (US), 1984, 82 p218-38,
ISSN 0065-9533
Jrnl Code: W49
Contract/Grant No.: R01-EY03513 Lang.: ENG.
Jrnl Ann.: 8509
Subfile: INDEX MEDICUS
Tags: Comparative Study; Human; Support, U.S. Gov't, P.H.S.
Desc.: Infant, Newborn; Infant, Premature; Retina--Pathology (PA); *Retinal Diseases--Classification (CL); Retinal Diseases--Congenital (CN); Retinal Diseases--Pathology (PA); Retinal Vessels--Pathology (PA); *Retrolental Fibroplasia--Classification (CL); Retrolental Fibroplasia--Pathology (PA)

Y015154 20
1689694 85214694
Retinopathy of prematurity: a statement by the committee on the fetus and newborn of the Paediatric Society of New Zealand.
NZ Med J (NEW ZEALAND), Jun 12 1985, 98 (780) p446-7,
ISSN 0028-8446
Jrnl Code: OBQ
Lang.: ENG.
Jrnl Ann.:Ann.: 8509
Subfile: INDEX MEDICUS
Tags: Human
Desc.: Gestational Age; Infant, Low Birth Weight; INFANT LBW; Infant, Newborn; New Zealand; *Retrolental Fibroplasia--Occurrence (OC); Retrolental Fibroplasia--Prevention and Control (PC); Risk

Y015154 21
1681582 85206582
Vitrectomy. Clinical data and cytologic findings of vitrectomy specimens.
Laatikainen L; Tarkkanen A; Koivuniemi A
Helsinki Univ. Central Hospital, Eye Clinic, Finland.
Int Ophthalmol (NETHERLANDS), Mar 1985, 7 (3-4) p215-22,
ISSN 0165-5701
Jrnl Code: GSF Lang.: ENG.
Jrnl Ann.: 8509
Subfile: INDEX MEDICUS
Fifty vitreous specimens obtained by routine pars plana vitrectomies were examined using Millipore filter processing and Papanicolaou staining technique. Cytological findings comprised of macrophages (melanophages, siderophages) and inflammatory cells, mainly lymphocytes. In a few cases, pigmented an nonpigmented epithelial cells of the ciliary body were encountered, retinal sensory cells only in one case. Fibroblasts and fragments of granulation tissue occurred in four of the 14 diabetic cases, in four of the 21 posttraumatic cases, in one case of chronic uveitis as well as in one case of retrolental fibroplasia. Fragments of ciliary body were in three specimens from injured eyes. In one case of chronic uveitis slight suspicion of ciliary body melanoma was aroused on the basis of distinct cellular atypia. There was agreement between clinical and cytological diagnosis in most cases, but particularly in posttraumatic and inflammatory diseases cytologic examination offered new diagnostic data. This is a new method of microscopical verification of the condition in the vitreous body in various diseases. Our experiences are preliminary but we feel that this method has proven its availability.
Tags: Human
Desc.: Diabetic Retinopathy--Pathology (PA); Eye Diseases--Pathology (PA); Hemorrhage--Pathology (PA); Inflammation--Pathology (PA); Retinal Detachment--Pathology (PA); Retrolental Fibroplasia--Pathology (PA); Uveitis--Pathology (PA); *Vitrectomy; Vitreous Body--Injuries (IN); *Vitreous Body--Pathology (PA); Wounds, Penetrating

Y015154 22
1668029 85193029
The retinopathy of prematurity: medicolegal aspects.
Bettman JW
Dept. of Ophthalmology, Pacific Medical Center, San Francisco, California.
Surv Ophthalmol (US), Mar-Apr 1985, 29 (5) p371-3,
ISSN 0039-6257
Jrnl Code: VCT
Lang.: ENG.
Jrnl Ann.: 8508
Subfile: INDEX MEDICUS
The incidence of medicolegal claims based on retinopathy of prematurity (ROP) diminished in the 1960s after the role of oxygen was presumed to be understood. It has since increased again for a number of reasons. More very premature infants are being saved. The causes of ROP are multifactorial, not well understood, and the role of oxygen as a significant factor is not always clear. Moreover, the risk/benefit ratio of supplemental oxygen is not always easy to evaluate. The morphologic features of ROP are common to a number of disorders, which may be misdiagnosed as ROP. In the series of 500 medicolegal claims that I have studied, no ophthalmologists have been sued in cases concerning ROP. However, they are routinely called as expert witnesses and it is to guide them in that role that I am reviewing the subject.
Tags: Human
Desc.: Diagnosis, Differential; DIAG DIFFER; Expert Testimony--Legislation and Jurisprudence (LJ); Infant, Newborn; *Malpractice--Legislation and Jurisprudence (LJ); Retrolental Fibroplasia--Diagnosis (DI); *Retrolental Fibroplasia--Etiology (ET); Risk Socioeconomic Factors; United States

Y015154 23
166?183 85190183
The infant who appears not to see well.
Fielder AR
Practitioner (ENGLAND), Apr 1985, 22 (1402) p353-9,
ISSN 0032-6518
Jrnl Code: PHQ
Lang.: ENG.
Jrnl Ann.: 8508
Subfile: INDEX MEDICUS
Tags: Female; Human
Desc.: Cataract--Diagnosis (DI); Color Blindness--Diagnosis (DI); Corneal Diseases--Diagnosis (DI); Infant; Infant, Newborn; Optic Nerve Diseases--Diagnosis (DI); Retinal Diseases--Diagnosis (DI); Retrolental Fibroplasia--Diagnosis (DI); *Vision Disorders--Diagnosis (DI)

Y015154 24
1664241 85189241
The treatment of advanced retinopathy of prematurity by cryotherapy and scleral buckling surgery.
Torilow HW; Ackerman AL; Wang FM
Dept. of Ophthalmology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York.
Ophthalmology (US), Mar 1985, 92 (3) p379-87,
ISSN 0161-6420
Jrnl Code: OI5 Lang.: ENG.
Jrnl Ann.: 8508
Subfile: INDEX MEDICUS
Seventeen eyes of nine extremely premature infants with severe acute proliferative retinopathy of prematurity (ROP, Grades III-V) were treated. Cryotherapy alone was used in ten eyes to ablate extensive areas of avascular retina to thereby induce involution of widespread intravitreous neovascularization. No attempt was made to directly treat the arteriovenous shunt or neovascularization itself. Scleral buckling surgery was used in combination with cryotherapy in seven additional eyes to relieve diffuse vitreous traction to intravitreous neovascularization which had caused extensive traction retinal detachment. Cryotherapy was uniformly successful in causing involution of widespread intravitreous neovascularization in all patients treated. Scleral buckling surgery was initially effective in reattaching the retina in all cases but late manifestations of severe ongoing vitreoretinal traction required additional open-sky vitrectomy in two eyes and resulted in inoperable recurrent total traction retinal detachment in one eye and extensive macular scarring in another. A comparison is made between the proliferative retinopathies seen in ROP and diabetes mellitus and a rationale for effective cryotherapy in ROP is presented. In our clinical experience, the single most important prognostic factor determining the potential severity of ROP is the width and extent of the retinal avascular zone. The wider the zone, the greater the probability of rapid progression from early to advanced grades of disease.
Tags: Human
Desc.: *Cryosurgery; Infant, Newborn; *Infant, Premature, Diseases--Surgery (SU); Ischemia--Surgery (SU); Neovascularization; Retinal Detachment--Surgery (SU); *Retinal Diseases--Surgery (SU); Retinal Vessels--Surgery (SU); Retrolental Fibroplasia--Surgery (SU); *Scleral Buckling

Y015154 25
1664240 85189240
Cryotherapy for retinopathy of prematurity. A personal retrospective.
Mousel DK
Univ. of Nevada School of Medicine, Reno.
Ophthalmology (US), Mar 1985, 92 (3) p375-8,
ISSN 0161-6420
Jrnl Code: OI5
Lang.: ENG.
Jrnl Ann.: 8508
Subfile: INDEX MEDICUS
Six patients from 1975 to 1981 were treated by cryotherapy for active retinopathy and prematurity. One eye was treated, leaving the second eye as a control. Cryotherapy was applied just posterior to the demarcation line, under direct observation and utilizing the cataract probe. Conclusions from this experience are that in order to be effective, cryotherapy must be performed comparatively early in Stage III. Unfortunately, this would lead to treatment of many cases that would spontaneously regress. Treatment of late Stage III, rapidly progressive cases is not impressive.
Tags: Case Report; Female; Human; Male
Desc.: *Cryosurgery; Follow-Up Studies; Infant, Newborn; *Infant, Premature, Diseases--Surgery (SU); Neovascularization; *Retinal Diseases--Surgery (SU); Retinal Hemorrhage--Surgery (SU); Retinal Vessels--Surgery (SU); Retrolental Fibroplasia--Surgery (SU); Scleral Buckling; Visual Acuity

Y015154 26
1654120 85179120
Growth and development in preterm infants during the first 18 months.
Forslund M; Bjerre I
Dept. of Pediatrics, Univ. of Lund, Malmo General Hospital, Sweden.
Early Hum Dev (NETHERLANDS), Jan 1985, 10 (1-4) p201-16,
ISSN 0378-3782
Jrnl Code: EDH Lang.: ENG.
Jrnl Ann.: 8508
Subfile: INDEX MEDICUS
In a long-term prospective study 46 unselected infants born before 35 completed weeks of gestational age were followed up, and compared to 26 fullterm infants. At 9 and 18 months of chronological age their height and weight were still lower than that of fullterms, but the difference disappeared when age was corrected for gestational age at birth. The motor and neurological maturity and language development was delayed in the preterms still at 18 months, which could possibly also be explained by their lower biological age. Ten of the preterm infants showed, at one or several occasions during follow up, definite neurological abnormality. At 18 months of age two of them were handicapped, one with retrolental fibroplasia, nearly blind, and another with cerebral palsy (slight spastic diplegic). Five of them had late psychomotor development, while two were borderline and one normal. We defined preand perinatal risk groups, but found that development at 18 months was not correlated to degree of risk. Neither was there any correlation between neurological examination at term and later handicap or psychomotor retardation. We found more illness, mostly due to common infections, during the first 18 months in the preterm group, as measured by the number of visits to a doctor and days spent in hospital.
Tags: Female; Human; Male
Desc.: Body Height; *Child Development; *Growth; Infant; Infant, Newborn; *Infant, Premature; Locomotion; Neurologic Examination; Reflex

Y015154 27
1624020 85149020
Handicaps and health problems in 2 year old children of birth weight 500 to 1500 g.
Ford GW; Rickards AL; Kitchen WH; Lissenden JV; Keith CG; Ryan MM
Royal Women's Hospital, Melbourne, Victoria, Australia.
Aust Paediatr J (AUSTRALIA), Feb 1985, 21 (1) p15-22,
ISSN 0004-993X
Jrnl Code: 9ID Lang.: ENG.
Jrnl Ann.: 8506
Subfile: INDEX MEDICUS
Fifty-nine infants of birthweight 500 to 999 g born in 1977 to 1980 and 132 infants of birthweight 1000 to 1500 g born in 1977 to 1978 were reviewed at two years corrected age. For the whole cohort, cerebral palsy was found in 12.6%, bilateral deafness in 1%, blindness in 1% and severe developmental delay in 12%. There was no significant difference in these disabilities between the groups of larger and smaller infants; 37.7% of the cohort was readmitted to hospital on at least one occasion, 35.6% of children had wheezing episodes and/or lower respiratory tract infections which together accounted for 51% of hospitalizations. The infants of birthweight 500 to 999 g tended to require more frequent and prolonged hospitalizations. Dolicocephalic head shape, chest deformities, iatrogenic sequelae from intensive care, poor growth and cicatricial retrolental fibroplasia were significantly more frequent in children of birthweight 500 to 999 g. Parents reported that 39% of their children had 'colic', 31.6% had sleep disturbance and 25% had multiple behavioural problems. Low frustration tolerance, inability to wait, hypoor hyperactivity and an inappropriate relationship with the mother as measured by the psychologist all occurred significantly more frequently in children of birthweight of less than 1000 g. This report confirms the belief that a comprehensive follow-up is required for very low birthweight (VLBW) children because significant health problems continue after primary hospitalization.
Tags: Human; Support, Non-U.S. Gov't
Desc.: Cerebral Palsy--Occurrence (OC); Child Behavior Disorders--Occurrence (OC); Child Development Disorders--Occurrence (OC); Child, Preschool; Deafness--Occurrence (OC); Eye Diseases--Occurrence (OC) Follow-Up Studies; *Handicapped; *Health Status; *Health; Hospitalization; *Infant Low Birth Weight; *INFANT LBW; Infant, Newborn; Morbidity; Respiratory Tract Infections--Occurrence (OC)

Y015154 28
1623693 85148693
Scanning electron microscopy of the ocular vasculature in retinopathy of prematurity.
Fryczkowski AW; Peiffer RL; Merritt JC; Kraybill EN; Eifrig DE
Dept. of Ophthalmology, Univ. of North Carolina, Chapel Hill.
Arch Ophthalmol (US), Feb 1985, 103 (2) p224-8,
ISSN 0003-9950
Jrnl Code: 830?
Lang.: ENG.
Jrnl Ann.: 8506
Subfile: AIM; INDEX MEDICUS
Clinicoanatomopathologic correlations in a case of the retinopathy of prematurity are reported. A premature infant delivered at 28 weeks of gestation (weight, 900 g) was hospitalized for a number of health problems, including bronchopulmonary dysplasia and respiratory distress syndrome. Ophthalmic examination, at the age of 5 months, disclosed stage 1B retinopathy of prematurity. The patient died at the age of 161 days; both eyes were taken for scanning electron microscopy and histopathologic studies. Scanning electron microscopy findings included absence of retinal capillaries, anterior uveal neovascularization originating from the venous side, and a coincidental typical coloboma of the optic nerve and choriocapillaris. Histopathologic findings confirmed iris stromal neovascularization, showed retinal neovascularization with proliferation into the vitreous and avascular areas between the midperiphery and ora serrata.
Tags: Case Report; Female; Human
Desc.: Blood Vessels--Ultrastructure (UL); Eye--Blood Supply (BS); Infant, Newborn; Microscopy, Electron, Scanning; Models, Anatomic; Neovascularization--Pathology (PA); *Retinal Vessels--Ultrastructure (UL); *Retrolental Fibroplasia--Pathology (PA); Uvea--Blood Supply (BS)

Y015154 29
1611641 85136641
Negligent treatment of premature infant causing retrolental fibroplasia: judge seeks pre-trial disclosure of medical reports.
Brahams D
Lancet (ENGLAND), Mar 9 1985, 1 (8428) p589-90,
ISSN 0140-6736
Jrnl Code: L0S Lang.: ENG.
Jrnl Ann.: 8506
Subfile: AIM; INDEX MEDICUS
Tags: Case Report; Human; Male
Desc.: *Infant Care; Infant, Newborn; *Infant, Premature; *Malpractice--Legislation and Jurisprudence (LJ); Medical Records; *Retrolental Fibroplasia--Etiology (ET)

Y015154 30
1593315 85118315
Nine-year follow up of infants weighing 1 500 g or less at birth.
Michelsson K; Lindahl E; Parre M; Helenius M
II Dept. of Paediatrics, Children's Hospital, Univ. of Helsinki, Finland.
Acta Paediatr Scand (SWEDEN), Nov 1984, 73 (6) p835-41,
ISSN 0001-656X
Jrnl Code: 1LV
Lang.: ENG.
Jrnl Ann.: 8505
Subfile: INDEX MEDICUS
A nine-year follow-up of 116 children born consecutively in 1971-74 with a birthweight of 1 500 g or less showed that 59 had died. Of those who were alive, four had severe motor and/or mental handicaps and three were blind because of retrolental fibroplasia. The low birthweight children without severe handicaps were found to have impaired motor function, speech defects and impaired school achievement more often than the controls. There was a significant correlation between the test results at the age of five and nine years, which indicates that children with school failure can be recognized and early remedial treatment started before school or on starting school.
Tags: Female; Human; Male; Support, Non-U.S. Gov't
Desc.: Birth Weight; *Child Development; Child; Child, Preschool; Follow-Up Studies; Handicapped; Infant Mortality; Infant; *Infant, Low Birth Weight; *INFANT LBW; Infant, Newborn; Mental Disorders--Etiology (ET) ; *Motor Skills; Pregnancy; PREGN; Prognosis; Risk

Y015154 31
1586988 85111988
Suppression of severe retinopathy of prematurity with vitamin E supplementation. Ultrastructural mechanism of clinical efficacy.
Hittner HM; Rudolph AJ; Kretzer FL
Cullen Eye Institute, Houston, TX.
Ophthalmology (US), Dec 1984, 91 (12) p1512-23,
ISSN 0161-6420
Jrnl Code: OI5
Contract/Grant No.: EY 02607
Lang.: ENG.
Jrnl Ann.: 8505
Subfile: INDEX MEDICUS
Three clinical trials enrolling 418 infants (less than or equal to 1500 g birth weight) and an ultrastructural data base of 71 pairs of whole eye donations have elucidated the efficacy of vitamin E in suppressing the development of severe retrolental fibroplasia (ROP). Only continuous vitamin E supplementation to adult physiologic levels from the first hours of life suppresses the development of severe ROP. Supplementation does not increase the incidence of necrotizing enterocolitis, sepsis, intraventricular hemorrhage, or mortality. Only multivariate analysis, which considers all risk factors simultaneously, is appropriate when appraising the efficacy of supplementation since all the clinical risk factors uniquely impinge on the oxygen dynamics of the developing retina. Mesenchymal spindle cells are the cellular mediators of the induction of ROP by oxygen in which increased oxygen tension triggers extensive gap junction formation between adjacent spindle cells. This cellular event, which occurs as early as four days of life, halts the normal vasoformative process and triggers neovascularization, which becomes clinically evident some 8 to 12 weeks later.
Tags: Animal; Human; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.
Desc.: Clinical Trials; Infant, Newborn; Infant, Premature, Diseases--Pathology (PA); *Infant, Premature, Diseases--Prevention and Control (PC); Intercellular Junctions--Ultrastructure (UL); Retina--Drug Effects (DE); Retina--Growth and Development (GD); *Retina--Ultrastructure (UL); Retinal Diseases--Pathology (PA); *Retinal Diseases--Prevention and Control (PC); Risk; Vitamin E--Pharmacodynamics (PD); *Vitamin E--Therapeutic Use (TU)
CAS Registry No.: 1406-18-4 (Vitamin E)

Y015154 32
1586987 85111987
Risk factors associated with retrolental fibroplasia. 
Biglan AW; Brown DR; Reynolds JD; Milley JR
Dept. of Ophthalmology, Univ. of Pittsburgh School of Medicine, Pennsylvania.
Ophthalmology (US), Dec 1984, 91 (12) p1504-11,
ISSN 0161-6420
Jrnl Code: OI?
Lang.: ENG.
Jrnl Ann.: 8505
Subfile: INDEX MEDICUS
The eyes of infants who were premature or had exposure to increased ambient oxygen from 1979 to 1981 were examined. Of 1012 neonates, 19 were found to have acute retrolental fibroplasia (RLF) grade III or worse in at least one eye. Sixteen also had chronic lung disease (CLD), and when compared to 25 control patients who had CLD but not grade III or more RLF, they were found to consistently have lower blood CO2 tensions (PCO2), lower pH values, higher inspired oxygen concentration (FIO2S) and a higher incidence of seizure disorders (100% vs. 48%). We could not show that an elevated PCO2 increased the risk for developing RLF. Infants with either chronic lung disease or chronic lung disease and seizures had a high risk for developing RLF grade III (39% and 57%, respectively).
Tags: Female; Human; Male; Support, Non-U.S. Gov't
Desc.: Carbon Dioxide--Blood (BL); Hydrogen-Ion Concentration; PH; Infant, Newborn; Length of Stay; Lung Diseases--Complications (CO); Oxygen--Adverse Effects (AE); Oxygen--Blood (BL); Retrolental Fibroplasia--Blood (BL); *Retrolental Fibroplasia--Etiology (ET); Retrospective Studies; Risk; Seizures--Complications (CO)
CAS Registry No.: 7782-44-7 (Oxygen)

Y015154 33
1586986 85111986
The natural history of active retinopathy of prematurity.
Tasman W
Retina Service, Wills Eye Hospital, Philadelphia.
Ophthalmology (US), Dec 1984, 91 (12) p1499-503,
ISSN 0161-6420
Jrnl Code: OI5 Lang.: ENG.
Jrnl Ann.: 8505
Subfile: INDEX MEDICUS
Two hundred twenty-one premature infants were examined in the premature nursery. Thirty-seven of the 221 (16.2%) had retinopathy of prematurity (ROP). Eight patients (21.5%) went blind and three other infants lost sight in one eye for a total of 19 sightless eyes (25.7%). The remaining 55 eyes (74.3%) retained vision. Birth weight was the most critical prognostic factor. Of eight babies who became blind all were under 1000 grams at birth, while babies who showed little change from active ROP were generally over 1300 grams. Nine of 14 eyes with only peripheral shunts (64%) resolved without dragging of the retina in the posterior pole. Sixteen eyes developed peripheral retinal detachment, and six of the sixteen (37.4%) had associated dilation and tortuosity of vessels in the posterior pole. Only one of these eyes resolved with minimal sequelae, suggesting that peripheral retinal detachment with dilated tortuous vessels was the most significant indicator of serious consequences.
Tags: Human
Desc.: *Blindness--Etiology (ET); Eye--Blood Supply (BS); Follow-Up Studies; *Infant, Low Birth Weight; *INFANT LBW; Infant, Newborn; *Infant, Premature, Diseases--Pathology (PA); Neovascularization--Pathology (PA); Prognosis; Retinal Detachment--Pathology (PA); Retinal Diseases--Complications (CO); *Retinal Diseases--Pathology (PA); Retinal Vessels--Pathology (PA); Vasodilation

Y015154 34
1586962 85111962
Incontinentia pigmenti associated with nasolacrimal duct obstruction.
Smith B; Bedrossian EH Jr
Oculoplastic Dept., New York Eye and Ear Infirmary, New York.
Ophthalmic Surg (US), Dec 1984, 15 (12) p980-2,
ISSN 0022-023X
Jrnl Code: OIC 
Lang.: ENG.
Jrnl Ann.: 8505
Subfile: INDEX MEDICUS
A case is reported of a five-month old female with incontinentia pigmenti associated with nasolacrimal duct obstruction. Ocular manifestations of incontinentia pigmenti have previously been described to include persistent hyperplastic primary vitreous, retinal dysplasia retrolental fibroplasia, corneal opacities, cataract, optic atrophy, and strabismus. This case is believed to be the first reported instance of incontinentia pigmenti associated with nasolacrimal duct obstruction. The management of this patient is also discussed.
Tags: Case Report; Female; Human
Desc.: Infant; *Lacrimal Apparatus--Surgery (SU); Lacrimal Duct Obstruction--Congenital (CN); Lacrimal Duct Obstruction--Embryology (EM); *Lacrimal Duct Obstruction--Surgery (SU); Nasolacrimal Duct--Embryology (EM); *Nasolacrimal Duct--Surgery (SU); *Pigmentation Disorders--Congenital (CN); Pigmentation Disorders--Embryology (EM); Syndrome

Y015154 35
1582466 851074?6
Increased morbidity in low-birth-weight survivors with severe retrolental fibroplasia.
Vohr BR; Coll CT
Dept. of Pediatrics, Women and Infants Hospital of Rhode Island, Providence.
J Pediatr (US), Feb 1985, 106 (2) p287-91,
ISSN 0022-3476
Jrnl Code: JLZ
Lang.: ENG.
Jrnl Ann.: 8505
Subfile: AIM; INDEX MEDICUS
Fourteen (2.2%) of 645 survivors with birth weight less than or equal to 1500 gm cared for in the Special Care Nursery between 1975 and 1981 were identified as having stage III-IV retrolental fibroplasia (RLF) in one or both eyes. These 14 survivors and 14 controls matched for birth weight have been observed for 2 to 7 years. There were no differences between survivors with RLF and controls in birth weight, gestation, multiple neonatal risk factors, or Hollingshead socioeconomic status. The only significant difference was in prolonged O2 requirements (greater than 2 weeks) (13 of 14 patients vs 7 of 14 control infants (P less than 0.025) and prolonged assisted ventilation requirements (21 +/- 15 for RLF vs 6 +/- 10 days for control infants, P less than 0.05). Follow-up assessments showed that the RLF survivors had a significantly higher incidence of neurologic abnormality, lower developmental quotients, increased requirements for special education, increased number of hospitalizations for illness, and more maternal stress as observed in the mother's adapted Life Experience Survey. We conclude that low-birth-weight infants with stage III-IV RLF are at a higher risk for neurodevelopmental problems and that their families are in need of comprehensive support services.
Tags: Female; Human; Male
Desc.: Child Development; Disease Susceptibility--Occurrence (OC); Family; Follow-Up Studies; *Infant, Low Birth Weight; *INFANT LBW; Infant, Newborn; Life Change Events; *Retrolental Fibroplasia--Occurrence (OC); Retrolental Fibroplasia--Physiopathology (PP); Retrolental Fibroplasia--Psychology (PX); Social Support; Socioeconomic Factors; Stress, Psychological--Occurrence (OC)

Y015154 36
1567665 85092665
[Oxygen therapy--underestimated risks]
Tlenoterapia--niedoc?niane niebezpieczenstwa.
Rogala B; Danek K
Wiad Lek (POLAND), Sep 15 1984, 37 (16) p1263-6,
ISSN 0043-5147
Jrnl Code: XOA
Lang.: POLISH
Doc. Type: Review
Jrnl Ann.: 8504
Subfile: INDEX MEDICUS (19 refs.)
Tags: Human
Desc.: Hyperbaric Oxygenation--Adverse Effects (AE); Hypercapnia--Etiology (ET); *Oxygen Inhalation Therapy--Adverse Effects (AE); Respiratory Distress Syndrome, Adult--Etiology (ET); Retrolental Fibroplasia--Etiology (ET); Risk

Y015154 37
1566076 85091076
[The retinopathy of prematurity
Prematuren-retinopathie (retinopathy of prematurity, ROP).
Cats BP; Tan KE
Afd. Neonatologie, Universitetskinderkliniek Het Wilhelmina Kinderziekenhuis, Utrecht.
Tijdschr Kindergeneeskd (NETHERLANDS), Oct 1984, 52 (5) p187-91,
ISSN 0376-7442
Jrnl Code: VST
Lang.: DUTCH
Summary Lang.: ENG.
Doc. Type: English Abstract
Jrnl Ann.: 8504
Subfile: INDEX MEDICUS
Throughout a four years period the development of retinopathy of prematurity (ROP) was determined amongst neonates considered 'at risk' for acquiring this condition. Fifty-six out of 249 neonates developed some degree of ROP. Comparison of the ROP-group with a group of 56 controls (admitted in the same period and matched for sex, birth-weight and gestational age) showed significant differences for sepsis, blood-transfusions and the period of O2-monitoring/period of O2-administration. The most consistent factor to which the development of ROP related was gestational age at the time of birth; no gestational age group however turned out to be absolutely devoid of ROP. This suggests that screening for ROP should not be restricted to 'high-risk' neonates only.
Tags: Female; Human; Male
Desc.: Blood Transfusion; Exchange Transfusion, Whole Blood; EXCHANGE TRANSFUSION; Infant, Newborn; Ophthalmoscopy; Oximetry--Methods (MT); Oxygen Inhalation Therapy--Adverse Effects (AE); Oxygen--Analysis (AN); *Retrolental Fibroplasia--Diagnosis (DI); Retrolental Fibroplasia--Etiology (ET)
CAS Registry No.: 7782-44-7 (Oxygen)

Y015154 38
1562088 85087088
Survival and short-term morbidity of the premature neonate.
Gilstrap LC 3d; Hauth JC; Bell RE; Ackerman NB Jr; Yoder BA; Delemos R
Dept. of Obstetrics and Gynecology, Wilford Hall US Air Force Medical Center, Lackland Air Force Base, Texas.
Obstet Gynecol (US), Jan 1985, 65 (1) 37-41,
ISSN 0029-7844
Jrnl Code: OC2
Lang.: ENG.
Jrnl Ann.: 8504
Subfile: AIM; INDEX MEDICUS
Obstetric decisions regarding premature (23 to 32 weeks' gestation) infants must be based on gestational age. However, most reports of the survival of premature infants are based on birth weight. The present report relates the perinatal survival and morbidity of 105 newborns to the obstetric gestational dating criteria between 23 and 32 weeks' gestation. Gestational age was determined from at least four obstetric criteria including the first day of the last menstrual period, early pelvic examination, the earliest auscultation of fetal heart tones with a fetoscope, fundal height measurements in centimeters between 20 and 30 weeks' gestation, and sonographic gestational age measurements. At 23 to 26 weeks' gestational age, nine (39%) of 23 neonates survived. Five of nine survivors had moderate to severe intracranial hemorrhage, three had moderate to severe bronchopulmonary dysplasia, and three had moderate to severe retrolental fibroplasia. At 27 to 29 weeks' gestational age, 25 (93%) of 27 neonates survived. Of the 25 survivors, three had moderate to severe intracranial hemorrhage, one had moderate to severe bronchopulmonary dysplasia, and one had severe retrolental fibroplasia. At 30 to 32 weeks' gestational age, 52 (95%) of 55 neonates survived. Three of the 52 (6%) survivors had serious neonatal morbidity consisting of moderate to severe intracranial hemorrhage (three neonates) and moderate to severe bronchopulmonary dysplasia (one neonate). Thus, ten of 34 (29%) survivors between gestational ages of 24 to 29 weeks had a serious morbidity versus only three of 52 (6%) survivors between 30 to 32 weeks' gestation (P less than .01).
Tags: Female; Human
Desc.: Bronchopulmonary Dysplasia--Occurrence (OC); Cerebral Hemorrhage--Occurrence (OC); Cesarean Section; Delivery--Methods (MT); Gestational Age; Infant, Newborn; *Infant, Premature, Diseases--Mortality (MO); Infant, Premature, Diseases--Occurrence (OC); Pregnancy; PREGN; Retrolental Fibroplasia--Occurrence (OC)

Y015154 39
1559?30 85084430
Immunopathological studies on retinopathy of prematurity (ROP).
Itoh H; Okuda T; Yamamoto M
?obe J Med Sci, Aug 1984, 30 (3-4) p53-61,
ISSN 0023-2513
Jrnl Code: KWR
Lang.: ENG.
Jrnl Ann.: 8504
Subfile: INDEX MEDICUS
Tags: Female; Human; Male
Desc.: Factor VIII--Analysis (AN); Fetal Death--Pathology (PA); Fibronectins--Analysis (AN); Glial Fibrillary Acidic Protein--Analysis (AN) ; GFAP--Analysis (AN); Histocytochemistry; Immunoenzyme Technics; Infant; Infant, Newborn; Infant, Premature; Nerve Tissue Protein S 100--Analysis (AN); Pregnancy; PREGN; Retinal Vessels--Pathology (PA); *Retrolental Fibroplasia--Pathology (PA); Stains and Staining

Y015154 40
1559378 85084378
[Current possibilities in the treatment of retrolental fibroplasia]
Aktualne mo.ANG.zliwosci leczenia zwLoknienia pozasoczewkowego.
Prost M
Klin Oczna (POLAND) Jul 1984, 86 (7) p309-11,
ISSN 0023-2157
Jrnl Code: KWC
Lang.: POLISH
Summary Lang.: ENG.
Doc. Type: English Abstract
Jrnl Ann.: 8504
Subfile: INDEX MEDICUS
Tags: Comparative Study; Human
Desc.: Cryosurgery--Methods (MT); Evaluation Studies; Infant; Infant, Newborn; Light Coagulation--Methods (MT); *Retrolental Fibroplasia--Surgery (SU); Vitrectomy--Methods (MT)

Y015154 41
1545351 85070351
Is bright room light related to retrolental fibroplasia [letter]
Warshauer AD
Anesthesiology (US), Dec 1984, 61 (6) p785-6,
ISSN 0003-3022
Jrnl Code: 4SG
Lang.: ENG.
Jrnl Ann.: 8503
Subfile: AIM; INDEX MEDICUS
Tags: Human
Desc.: Infant, Newborn; *Lighting--Adverse Effects (AE); *Retrolental Fibroplasia--Etiology (ET)

Y015154 42
1537686 85062686
Intraventricular hemorrhage and vitamin E in the very low-birth-weight infant: evidence for efficacy of early intramuscular vitamin E administration
Speer ME; Blifeld C; Rudolph AJ; Chadda P; Holbein ME; Hittner HM
Dept. of Pediatrics, Baylor College of Medicine, Houston, TX.
Pediatrics (US), Dec 1984, 74 (6) p1107-12,
ISSN 0031-4005
Jrnl Code: O?V
Lang.: ENG.
Jrnl Ann.: 8503
Subfile: AIM; INDEX MEDICUS
To determine whether early intramuscular vitamin E supplementation influences the incidence of intraventricular hemorrhage (IVH) in infants with birth weight less than or equal to 1, 500 g, data were analyzed from 134 infants enrolled on a protocol to evaluate the efficacy of intramuscular plus oral vitamin E v oral supplementation alone in the treatment of retrolental fibroplasia. All 134 infants received, via nasogastric tube, 100 mg/kg/d of vitamin E daily (dl-alpha-tocophery acetate in MCT [medium-chain triglyceride] oil; 150 mosM) for at least 8 weeks with the first dose administered within the first eight hours of life. Sixty-four patients received, in addition, intramuscular vitamin E on days 1, 2, 4, and 6 of life and 70 patients received placebo injections in a randomized double-blind fashion. In the first week, vitamin E plasma levels were significantly higher in the 64 patients given intramuscular vitamin E. In spite of this difference no change in the incidence of sepsis or necrotizing enterocolitis was observed. Both the incidence and severity of intraventricular hemorrhage were reduced significantly in the patients given intramuscular vitamin E as compared to the patients given placebo (P .013 and P = .04, respectively). The data suggest that vitamin E, a natural antioxidant, may play an important role in protecting the CNS microcirculation from the effects of hypoxic/ischemic injury.
Tags: Human; Support, Non-U.S. Gov't
Desc.: Administration, Oral; *Cerebral Hemorrhage--Prevention and Control (PC); Cerebral Ventricles; Double-Blind Method; Drug Evaluation; Emulsions; *Infant, Low Birth Weight; *INFANT LBW; Infant, Newborn; *Infant, Premature, Diseases--Prevention and Control (PC); Injections, Intramuscular; Random Allocation; Vitamin E--Administration and Dosage (AD) ; Vitamin E--Blood (BL); *Vitamin E--Therapeutic Use (TU)
CAS Registry No.: 1406-18-4 (Vitamin E)

Y015154 43
1537665 85062665
[Problems of the prevention of retrolental fibroplasia]
Problemy profilaktyki zwLoknienia pozasoczewkowego.
Prost M 
Pediatr Pol (POLAND), Jun 1984, 59 (6) p507-11,
ISSN 0031-3939
Jrnl Code: OW2
Lang.: POLISH
Jrnl Ann.: 8503
Subfile: INDEX MEDICUS
Tags: Human
Desc.: Infant, Newborn; Oxygen Inhalation Therapy--Adverse Effects (AE); Oxygen Inhalation Therapy--Methods (MT); Oxygen--Administration and Dosage (AD); Retrolental Fibroplasia--Etiology (ET); *Retrolental Fibroplasia--Prevention and Control (PC)
CAS Registry No.: ?782-44-7 (Oxygen)

Y015154 44
1537472 85062472
[Treatment of retrolental fibroplasia by transscleral cryopexy]
Retrolentalis fibroplasia kezelese transscleralis cryopexiaval.
Jobbagyi P; Gocze P; Horvath I
Orv Hetil (HUNGARY), Nov 18 1984, 125 (47) p2847-52,
ISSN 0030-6002
Jrnl Code: OL8
Lang.: HUNGARIAN
Summary Lang.: ENG.
Doc. Type: English Abstract
Jrnl Ann.: 8503
Subfile: INDEX MEDICUS
Tags: Human
Desc.: *Cryosurgery; Infant, Newborn; Retina--Surgery (SU); *Retrolental Fibroplasia--Surgery (SU); S?lera--Surgery (SU)

Y015154 45
1532543 85057543
Long-term neuropsychological impact of retrolental fibroplasia: review and implications.
Scharf LS; Adams KM
J Pediatr Psychol (US), Sep 1984, 9 (3) 303-16,
ISSN 0146-8693
Jrnl Code: JL8
Lang.: ENG.
Doc. Type: Review
Jrnl Ann.: 8503
Subfile: INDEX MEDICUS (40 Refs.)
Tags: Human; Support, Non-U.S. Gov't
Desc.: Adolescence; Birth Weight; Blindness--Etiology (ET); Blindness--Psychology (PX); Child Development Disorders--Etiology (ET); Child Development Disorders--Psychology (PX); Child; Child, Preschool; Electroencephalography; EEG; Family; Infant; Infant, Newborn; Infant, Premature--Psychology (PX); Intelligence; Mental Retardation--Complications (CO); Retrolental Fibroplasia--Complications (CO); *Retrolental Fibroplasia--Psychology (PX); Stereotyped Behavior

Y015154 46
1512574 85037574
[Retrolental fibroplasia in premature infants during the past 20 years ]
A retrolentalis fibroplasia 20 ev koraszulott betegein.
Czappan P; Veli M
Orv Hetil (HUNGARY), Oct 28 1984, 125 (44) p265-63,
ISSN 0030-6002
Jrnl Code: OL8
Lang.: HUNGARIAN
Summary Lang.: ENG.
Doc. Type: English Abstract
Jrnl Ann.: 8502
Subfile: INDEX MEDICUS
Tags: Human
Desc.: Hungary; Infant, Newborn; Retrolental Fibroplasia--Etiology (ET); *Retrolental Fibroplasia--Occurrence (OC)

Y015154 47
1500711 85025711
Use of mechanical ventilation for clinical management of persistent pulmonary hypertension of the newborn.
Duara S; Gewitz MH; Fox WW
Univ. of Maryland School of Medicine, Baltimore.
Clin Perinatol (US), Oct 1984, 11 (3) p641-52,
ISSN 0095-5108
Jrnl Code: DHH
Lang.: ENG.
Jrnl Ann.: 8502
Subfile: INDEX MEDICUS
Following a discussion of arterial blood gas examinations for specific diagnosis of PPHN, the authors present guidelines for the management of these infants using mechanical ventilation.
Tags: Human
Desc.: Carbon Dioxide--Blood (BL); Diagnosis, Differential; DIAG DIFFER; Echocardiography; Follow-Up Studies; Heart Diseases--Diagnosis (DI) ; Infant; Infant, Newborn; Monitoring, Physiologic; Oxygen--Blood (BL); Persistent Fetal Circulation Syndrone--Blood (BL); PFC SYNDROME--Blood (BL) ; Persistent Fetal Circulation Syndrome--Diagnosis (DI); PFC SYNDROME--Diagnosis (DI); *Persistent Fetal Circulation Syndrome--Therapy (TH); *PFC SYNDROME--Therapy (TH); *Respiration, Artificial; Respiration, Artificial--Adverse Effects (AE); Respiration, Artificial--Methods (MT); Retrolental Fibroplasia--Etiology (ET)
CAS Registry No.: 7782-44-7 (Oxygen)

Y015154 48
1487141 85012141
Retinopathy of prematurity in extremely low birthweight infants.
Keith CG; Kitchen WH
Royal Women's Hospital, Carlton, Vic. 
Med J Aust (AUSTRALIA), Aug 18 1984, 141 (4) p225-7,
ISSN 0025-729X
Jrnl Code: M26
Lang.: ENG.
Jrnl Ann.: 8501
Subfile: INDEX MEDICUS
From 1977 to 1982, 108 infants weighing less than ?000 g at birth were examined in a nursery for premature babies for evidence of retinopathy of prematurity (ROP). Of these 108 infants, 88 were subjected to follow-up examinations for periods of 10 months to six years. ROP had been observed in 53% (47/88) of these children; it had been severe in 31% (27/88). Subsequently, 19% (17/88) of these children developed retrolental fibroplasia (RLF); all of these had had severe ROP, except one, in whom it is presumed to have been missed. The RLF was severe in only one eye of one child. Each of these infants had received only 25 mg of vitamin E by mouth.
The writers consider that the case for the administration of large doses of Vitamin E in the prevention of RLF is still not proven and conclude that, if vitamin E does have a protective effect, then a dose of 25 mg is sufficient.
Tags: Human
Desc.: Infant; *Infant, Low Birth Weight; *INFANT LBW; Infant, Newborn; Oxygen Inhalation Therapy--Adverse Effects (AE); *Retrolental Fibroplasia; Retrolental fibroplasia--Classification (CL); Retrolental Fibroplasia--Etiology (ET); Retrolental Fibroplasia--Occurrence (OC); Vitamin E--Therapeutic Use (TU)
CAS Registry No.: 1406-18-4 (Vitamin E)

Y015154 49
1487135 85012135
Retinopathy of prematurity and vitamin E [editorial]
Newman NM
Royal Hobart Hospital.
Med J Aust (AUSTRALIA) Aug 18 1984, 141 (4) p209-11,
ISSN 0025-729X
Jrnl Code: M26
Lang.: ENG.
Jrnl Ann.: 8501
Subfile: INDEX MEDICUS
Tags: Animal; Human
Desc.: Cats; Child, Preschool; Dogs; Infant; Infant, Newborn; Mice Oxygen Inhalation Therapy--Adverse Effects (AE); *Retrolental Fibroplasia--Prevention and Control (PC); *Vitamin E--Therapeutic Use (TU)
CAS Registry No.: 1406-18-4 (Vitamin E)

Y015154 50
1481164 85006164
Retinal oxygen tension and oxygen reactivity in retinopathy of prematurity in kittens.
Ernest T; Goldstick TK
Dept. of Ophthalmology, Eye and Ear Infirmary, Univ. of Illinois at Chicago.
Invest Ophthalmol V?s Sci (US), Oct 1984, 25 (10) p1129-34,
ISSN 0146-0404
Jrnl Code: GWI
Contract/Grant No.: EY-04085
Lang.: ENG.
Jrnl Ann.: 8501
Subfile: INDEX MEDICUS
In the first series of experiments, preretinal oxygen tensions were measured using microelectrodes in newborn kittens, at 6 +/- 2 days of age, following their placement in an atmosphere of 80 to 90% oxygen for 5 +/- 1 day. The oxygen exposure caused an obliteration of the normally developing retinal vasculature. Preretinal oxygen tensions in the resultant avascular retina were close to zero while those in the vascular retina were near normal. The avascular retina was a "sink" for ocular oxygen. Oxygen breathing resulted in expected increases in preretinal oxygen tension, but, surprisingly, the preretinal oxygen tension decreased with continued oxygen administration. Because the oxygen tension in the avascular retinal area is determined primarily by the choroidal circulation, we speculated that increased oxygen caused a decreased choroidal blood flow. In the second series of experiments, however, choroidal blood flow was measured in the kittens by applying a temperature probe to the sclera and oxygen breathing did not appear to have an effect. These results did not support the initial speculation. It may be that the decrease in preretinal oxygen tension observe with continued oxygen administration resulted from progressive increase in utilization.
Tags: Animal; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.
Desc.: Animals, Newborn; Cats; Choroid--Blood Supply (BS); Intermittent Positive Pressure Breathing; Neovascularization; Optic Disk--Blood Supply (BS); Oxygen Consumption; Oxygen--Administration and Dosage (AD); *Oxygen--Analysis (AN); Oxygen--Blood (BL); *Retina--Metabolism (ME); Retinal Vessels--Metabolism (ME); Retrolental Fibroplasia--Etiology (ET); *Retrolental Fibroplasia--Metabolism (ME)
CAS Registry No.: 7782-44-7 (Oxygen)

Y015154 51
1477954 85002954
Severe bronchopummonary dysplasia. Predictors of survival and outcome.
Shankaran S; Szego E; Eizert D; Siegel P
Dept. of Pediatrics, Wayne State Univ., Detroit.
Chest (US), Oct 1984, 86 (4) p607-10,
ISSN 0012-3692
Jrnl Code: D1C Lang.: ENG.
Jrnl Ann.: 8501
Subfile: AIM; INDEX MEDICUS
Predictors of survival and outcome were evaluated following severe bronchopulmonary dysplasia in 35 neonates, 15 of whom died during the initial hospitalization and four following discharge. There was no difference in the clinical characteristics between those infants who survived or died. The survival rate was 47 percent when the length of stay in the hospital was three months and was 17 percent when the length of stay was five months. The survival rate was 27 percent when the time receiving oxygen was three months. There were no survivors when the time receiving oxygen was longer than five months. Follow-up of 13 survivors revealed that four had neurologic sequelae, and two had severe retrolental fibroplasia. When comparing infants with a mean mental developmental index of less than 84 (n = 8) to those with more than 85 (n = 5) on the Bayley Scales of Infant Development, mean length of hospitalization was 125 days vs 72 days (p less than 0.05), and the time receiving oxygen was 84 days vs 46 days (p less than 0.05). When comparing infants with growth parameters below the 5th percentile (n = 4) to those above the 5th percentile (n = 9), the mean time receiving oxygen was 94 days compared to 58 days (p less than 0.05). Severe bronchopulmonary dysplasia is associated with a high mortality and morbidity, both in and beyond the neonatal period.
Tags: Female; Human; Male
Desc.: Birth Weight; Bronchopulmonary Dysplasia--Complications (CO) ; *Bronchopulmonary Dysplasia--Mortality (MO); Follow-Up Studies; Gestational Age; Infant; Infant, Newborn; Length of Stay; Prognosis; Psychological Tests; Respiration, Artificial--Adverse Effects (AE); Sex Factors; Time Factors

Y015154 52
1475374 85000374
An international classification of retinopathy of prematurity. Prepared by an international committee.
Br J Ophthalmol (ENGLAND), Oct 1984, 68 (10) p690-7,
ISSN 0007-1161
Jrnl Code: AZK
Contract/Grant No.: EY03513; EY01723; EY03473; + Lang.: ENG.
Jrnl Ann.: 8501
Subfile: INDEX MEDICUS
Tags: Human; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.
Desc.: Fluorescein Angiography; Infant, Newborn; Medical Records; Methods; *Retrolental Fibroplasia--Classification (CL); Retrolental Fibroplasia--Pathology (PA)

Y015154 53
1475373 85000373
Retrolental fibroplasia now retinopathy of prematurity [editorial]
Ashton N
Br J Ophthalmo (ENGLAND), Oct 1984, 68 (10) p689,
ISSN 0007-1161
Jrnl Code: AZK Lang.: ENG.
Jrnl Ann.: 8501
Subfile: INDEX MEDICUS

Y015154 54
1439576 84279576
An international classification of retinopathy of prematurity. The Committee for the Classification of Retinopathy of Prematurity.
Arch Ophthalmol (US), Aug 1984, 102 (8) p1130-4,
ISSN 0003-9950
Jrnl Code: 830
Contract/Grant No.: EYO3513; EYO1723; EYO3473
Lang.: ENG.
Jrnl Ann.: 8411
Subfile: AIM; INDEX MEDICUS
Because of modern life-support systems capable of keeping tiny premature infants alive, retinopathy of prematurity has recurred. No classification system currently available adequately describes the observations of the disease being made today. A new classification system, the work of 23 ophthalmologists from 11 countries, is presented in an attempt to meet this need. It emphasizes the location and the extent of the disease in the retina as well as its stages. The term "plus" is employed with the stage to denote progressive vascular incompetence. A computer-compatible diagram for recording the results of the examination employing the new classification system is furnished.
Tags: Human; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.
Desc.: Infant, Newborn; Medical Records; *Retrolental Fibroplasia--Classification (CL); Retrolental Fibroplasia--Pathology (PA)

Y015154 55
1439575 84279575
The new international classification of retinopathy of prematurity [editorial]
Patz A
Arch Ophthalmol (US), Aug 1984, 102 (8) p1129,
ISSN 0003-9950
Jrnl Code: 830
Lang.: ENG.
Jrnl Ann.: 8411
Subfile: AIM; INDEX MEDICUS
Tags: Human
Desc.: Infant, Newborn; *Retrolental Fibroplasia--Classification (CL)

Y015154 56
1437219 84277219
[Experimental studies on retinopathy of prematurity (V). platelet aggregation and lipid peroxide in kitten blood after oxygen administration]
Taki M; Majima A; Takada M
Nippon Ganka Gakkai Zasshi (JAPAN), Apr 1984, 88 (4) p680-5,
ISSN 0029-0203
Jrnl Code: 22O
Lang.: JAPANESE
Summary Lang.: ENG.
Doc. Type: English Abstract
Jrnl Ann.: 8411
Subfile: INDEX MEDICUS
Tags: Animal; Support, Non-U.S. Gov't
Desc.: Animals, Newborn; Cats; *Lipid Peroxides--Blood (BL); *Oxygen--Toxicity (TO); *Platelet Aggregation--Drug Effects (DE); *Retrolental Fibroplasia--Etiology (ET); Thrombosis--Etiology (ET); Vitamin E--Pharmacodynamics (PD)
CAS Registry No.: 1406-18-4 (Vitamin E); 7782-44?7 (Oxygen)

Y015154 57
1437201 84277201
[Retinopathy of prematurity in infants with very low birthweight, especially in extreme prematurity]
Tochikubo T; Hosozawa K; Uga N; Fujii T
Nippon Ganka Gakkai Zasshi (JAPAN), Mar 1984, 88 (3) p540-9,
ISSN 0029-0203
Jrnl Code: 22O
Lang.: JAPANESE
Summary Lang.: ENG.
Doc. Type: English Abstract
Jrnl Ann.: 8411
Subfile: INDEX MEDICUS
Tags: Human
Desc.: Cryosurgery; Infant, Newborn; Oxygen Inhalation Therapy--Adverse Effects (AE); *Retrolental Fibroplasia--Etiology (ET); Retrolental Fibroplasia--Therapy (TH)

Y015154 58
1427160 84267160
Clinical course to 1 year of age in premature infants with patent ductus arteriosus: results of a multicenter randomized trial of indomethacin.
Peckham GJ; Miettien OS; Ellison RC; Kraybill EN; Gersony WM; Zierler S Nadas AS
Division of Neonatology, Children's Hospital of Philadelphia, Pa.
J Pediatr (US), Aug 1984, 105 (2) p285-91,
ISSN 0022-3476
Jrnl Code: JLZ
Contract/Grant No.: HL 23121
Lang.: ENG.
Jrnl Ann.: 8411
Subfile: AIM; INDEX MEDICUS
Reported are 1-year follow-up results of a randomized clinical trial comparing three strategies of managing clinically significant patent ductus arteriosus at the time of diagnosis in premature infants: (1) immediate administration of a three-dose course of intravenously administered indomethacin in addition to usual medical therapy (fluid restriction and use of diuretics or digitalis or both), with surgery as a backup measure, (2) usual medical therapy alone initially, with indomethacin as the first and surgery as the final backup measure, and (3) usual medical therapy alone initially, with surgery alone as backup. Of primary concern were the relative merits of these three managements strategies in the terms of the long-term occurrence of a wide range of health problems. Although at the time of neonatal hospitalization there was a significant excess of bleeding episodes in infants receiving indomethacin as part of initial treatment, and a significantly higher rate of retrolental fibroplasia in the those given usual medical therapy with surgery as backup, there were no statistically significant differences at 1 year of age related to these intermediate outcomes. In other regards, too, the treatment strategies appeared interchangeable in terms of the 1-year outcome.
Tags: Comparative Study; Female; Human; Male; Support, U.S. Gov't, P.H.S.
Desc.: Bronchopulmonary Dysplasia--Etiology (ET); Child Development ; Clinical Trials; Combined Modality Therapy; Ductus Arteriosus, Patent--Complications (CO); *Ductus Arteriosus, Patent--Drug Therapy (DT); Ductus Arteriosus, Patent--Mortality (MO); Ductus Arteriosus, Patent--Therapy (TH); Follow-Up Studies; Indomethacin-Adverse Effects (AE) ; *Indomethacin--Therapeutic Use (TU); Infant, Newborn; Infant, Premature, Diseases--Complications (CO); *Infant, Premature, Diseases--Drug Therapy (DT); Infant, Premature, Diseases--Mortality (MO); Infant, Premature, Diseases--Therapy (TH); Patient Readmission; Random Allocation; Retrolental Fibroplasia--Chemically Induced (CI)
CAS Registry No.: 53-86-1 (Indomethacin)

Y015154 59
1423928 84263928
Assessment and prediction of visual acuity in 3- to 4-year-old children born prior to term.
Sebris SL; Dobson V; Hartmann EE
Dept. of Psychology, Univ. of Washington, Seattle.
Hum Neurobiol (GERMANY, WEST), 1984, 3 (2) p87-92,
ISSN 0721-9075
Jrnl Code: G9X
Contract/Grant No.: EY 02581
Lang.: ENG.
Jrnl Ann.: 8411
Subfile: INDEX MEDICUS
Previous studies of school-age children born prior to term indicate that they often have visual acuity that is slightly poorer than normal. However, visual acuity results for preschool-age preterm children have not been reported. In this study, we used the operant preferential looking procedure to measure the visual acuities of 23 3- to 4-year-old preterm children. The results indicated that, although many of the children had acuities within the normal range, the average acuity of the preterm children was slightly poorer than that of full-term children of the same age, even when children with significant refractive errors were eliminated from the sample. Neither birthweight, gestational age at birth, nor the presence of respiratory distress syndrome during infancy were predictive of later visual acuity. However, preferential looking acuity screening at 4 months corrected age did have some predictive value, in that 3 of the 4 infants who failed to complete testing at 4 months showed poor performance at 3 to 4 years of age.
Tags: Human; Support, U.S. Gov't, P.H.S.
Desc.: Birth Weight; Child, Preschool; Eye Diseases--Complications (CO); Infant, Newborn; *Infant, Premature; Refractive Errors--Complications (CO); Refractometry--Methods (MT); Respiratory Distress Syndrome--Complications (CO); Retrolental Fibroplasia--Complications (CO); Vision Disorders--Complications (CO); Vision Disorders--Diagnosis (DI); *Vision Disorders--Occurrence (OC); *Visual Acuity

Y015154 60
1419677 84259677
[Is the premature infant still threatened with retrolental fibroplasia in 1983]
Le premature est-il encore menace de fibroplasie retro-lentale en 1983
Gerhard JP; Willard D
Bull Soc Ophtalmol Fr (FRANCE), Aug-Sep 1983, 83 (8-9) p987-90,
ISSN 0081-1270
Jrnl Code: C40
Lang.: FRENCH
Summary Lang.: ENG.
Doc. Type: Eng. Abstract
Jrnl Ann.: 8411
Subfile: INDEX MEDICUS
Tags: Human
Desc.: Infant, Low Birth Weight; INFANT LBW; Infant, Newborn; *Retrolental Fibroplasia--Occurrence (OC); Retrolental Fibroplasia--Pathology (PA); Retrolental Fibroplasia--Prevention and Control (PC)

Y015154 61
14139?1 84253961
Retrolental fibroplasia in full-term infants without exposure to supplemental oxygen [letter]
van Nouhuys E
Am J Ophthalmol (US), Jul 15 1984, 98 (1) p124-5,
ISSN 0002-9394
Jrnl Code: ?3OQ
Lang.: ENG.
Jrnl Ann.: 8410
Subfile: AIM; INDEX MEDICUS
Tags: Human
Desc.: Infant, Newborn; *Retina--Abnormalities (AB); *Retrolental Fibroplasia--Familial and Genetic (FG); Retrolental Fibroplasia--Pathology (PA)

Y015154 62
1411205 84251205
Update on retrolental fibroplasia.
Biglan AW
Trans Pa Acad Ophthalmol Otolaryngol (US), Spring 1984, 37 (1) p39-43,
ISSN 0048-3206
Jrnl Code: WA?
Lang.: ENG.
Jrnl Ann.: 8410
Subfile: INDEX MEDICUS
Tags: Animal; Human; Support, Non-U.S. Gov't
Desc.: Child; Dogs; Infant; Infant, Low Birth Weight; INFANT LBW; Infant, Newborn; Infant, Premature; Retrolental Fibroplasia--Classification (CL); *Retrolental Fibroplasia--Physiopathology (PP); Retrolental Fibroplasia--Therapy (TH); Risk

Y015154 63
1409704 84249704
[Experimental research on the etiopathogenesis of retrolental fibroplasia]
Ricerca sperimentale sulla etiopatogenesi della fibroplasia retrolenticolare.
Cerrati A; Bertoni G; Ciceri D; Grasso M; Italiano D; Marincola F; Ruggieri G
Riv Med Aer?naut Spaz (ITALY), Jan-Dec 1982, 47 (1-4) p225-34,
ISSN 0035-631X
Jrnl Code: TNL
Lang.: ITALIAN
Summary Lang.: ENG.
Doc. Type: English Abstract
Jrnl Ann.: 8410
Subfile: INDEX MEDICUS
Tags: Animal
Desc.: Cats; *Hyperbaric Oxygenation--Adverse Effects (AE); Research; Retinal Hemorrhage--Etiology (ET); Retinal Hemorrhage--Pathology (PA); Retinal Vessels--Pathology (PA); *Retrolental Fibroplasia--Etiology (ET); Retrolental Fibroplasia--Pathology (PA)

Y015154 64
1407175 84247175
New international classification of retinopathy of prematurity.
Patz A
Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Baltimore.
Pediatrics (US), Jul 1984, 74 (1) p160-1,
ISSN 0031-4005
Jrnl Code: OXV
Lang.: ENG.
Jrnl Ann.: 8410
Subfile: AIM; INDEX MEDICUS
Tags: Human
Desc.: Infant, Newborn; *Infant, Premature, Diseases--Classification (CL); *Retrolental Fibroplasia--Classification (CL)

Y015154 65
1407164 84247164
An international classification of retinopathy of prematurity.
Pediatrics (US), Jul 1984, 74 (1) p127-33,
ISSN 0031-4005
Jrnl Code: OXV
Contract/Grant No.: EY03513; EY01723; EY03473
Lang.: ENG.
Jrnl Ann.: 8410
Subfile: AIM; INDEX MEDICUS
Tags: Human; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.
Desc.: Acute Disease; Cicatrix--Pathology (PA); Fluorescein Angiography; Infant, Newborn; *Infant, Premature, Diseases--Classification (CL); Infant, Premature, Diseases--Pathology (PA); *Retinal Diseases--Classification (CL); Retinal Diseases--Pathology (PA); Retrolental Fibroplasia--Classification (CL)

Y015154 66
1406793 84246793
Surgical results of stage V retrolental fibroplasia and timing of surgical repair.
Trese MT
William Beaumont Hospital, Michigan State Univ., Division of Ophthalmology.
Ophthalmology (US), May 1984, 91 (5) p461-6,
ISSN 0161-6420
Jrnl Code: OI5
Lang.: ENG.
Jrnl Ann.: 8410 
Subfile: INDEX MEDICUS
Analysis of forty Stage V RLF eyes which underwent lensectomy, pars plicata vit?ectomy, membrane peeling and scleral buckling surgery with a minimum 6-month follow-up is presented. Anatomic reattachment was achieved in 45% of eyes. Functional success was achieved in 30% of eyes. Prognostic indicators such as the configuration of the tractional detachment, vascularization of the iris and retrolenticular membrane were analyzed. This analysis showed that timing of surgery may alter surgical success. This information, coupled with the variable rates of progression of the RLF process, suggests more frequent examination of the children at risk than as currently suggested is necessary to allow maximum benefit.
Tags: Female; Human; Male
Desc.: Follow-up Studies; Infant; Infant, Newborn; Lens, Crystalline--Surgery (SU); Prognosis; Retinal Detachment--Surgery (SU); *Retrolental Fibroplasia--Surgery (SU); Scleral Buckling; Vitreous Body--Surgery (SU)

Y015154 67
1395050 84235050
Concerning the article "Ultrastructural evaluation of the retina in retinopathy of prematurity and correlations with vitamin E therapy".
Kretzer FL; Hittner HM; Godio LB
Curr Eye Res (ENGLAND), Jun 1984, 3 (6) p881-2,
ISSN 0271-3683
Jrnl Code: DUB
Lang.: ENG.
Jrnl Ann.: 8410
Subfile: INDEX MEDICUS
Tags: Human
Desc.: Infant, Newborn; Retina--Drug Effects (DE); *Retrolental Fibroplasia--Drug Therapy (DT); *Vitamin E--Therapeutic Use (TU)
CAS Registry No.: 1406-18-4 (Vitamin E)

Y015154 68
1385513 84225513
Acute proliferative retrolental fibroplasia: multivariate risk analysis.
Flynn JT
Bascom Palmer Eye Institute, Dept. of Ophthalmology, Univ. of Miami School of Medicine, Florida.
Trans Am Ophthalmol Soc (US), 1983, 81 p549-91,
ISSN 0065-9533
Jrnl Code: W49
Contract/Grant No.: EYO3513-01
Lang.: ENG.
Jrnl Ann.: 8409
Subfile: INDEX MEDICUS
This study has presented a two-way analysis of a data set consisting of demographic, diagnostic, and therapeutic variables against the risk of occurrence of APRLF and its location in the retina in a population of 639 infants in birthweights ranging from 600 to 1500 gm. Univariate and multivariate risk analysis techniques were employed to analyze the data. As established from previous studies, birthweight was a powerful predictor of the outcome variable. Oxygen therapy as defined and quantified in this study was not. Duration of ventilatory assistance did seem associated. The population was not uniform. Infants below 1000 gm birthweight had such a high incidence of APRLF that no other exogenous risk factors seemed of significance. Above 1000 gm birthweight, certain factors, particularly duration of ventilation, seemed of predictive strength and significance.
Tags: Female; Human; Male; Support, U.S. Gov't, P.H.S.
Desc.: Analysis of Variance; Anemia--Complications (CO); Apnea--Complications (CO); Birth Weight; Bronchopulmonary Dysplasia--Complications (CO); Cerebral Hemorrhage--Complications (CO); Ductus Arteriosus, Patent--Complications (CO); Fundus Oculi; Heart Failure, Congestive--Complications (CO); Infant, Low Birth Weight; INFANT LBW; Infant, Newborn; Oxygen Inhalation Therapy--Adverse Effects (AE); Respiratory Distress Syndrome--Complications (CO); Retrolental Fibroplasia--Diagnosis (DI); Retrolental Fibroplasia--Etiology (ET); *Retrolental Fibroplasia--Occurrence (OC); Risk

Y015154 69
1384641 84224641
[Clinical significance of retinopathy in premature infants]
Zur klinischen Bed?utung der Fruhgeborenen-Retinopathie.
Koerner F; Bossi E
Ther Umsch (SWITZERLAND), Apr 1984, 41 (4) p281-6
ISSN 0040-5930
Jrnl Code: VPT
Lang.: GERMAN
Summary Lang.: ENG.
Doc. Type: English Abstract
Jrnl Ann.: 8409
Subfile: INDEX MEDICUS
Tags: Human
Desc.: Infant, Newborn; *Retrolental Fibroplasia; Retrolental Fibroplasia--Diagnosis (DI); Retrolental Fibroplasia--Prevention and Control (PC)

Y015154 70
1381149 84221149
Retinal and choroidal blood flows in hypoxic and hypercarbic newborn lambs.
Milley JR; Rosenberg AA; Jones MD Jr
Dept. of Pediatrics, Johns Hopkins Univ. School of Medicine, Baltimore, Maryland.
Pediatr Res (US), May 1984, 18 (5) p410-4,
ISSN 0031-3998
Jrnl Code: OWL
Contract/Grant No.: EY-02482
Lang.: ENG.
Jrnl Ann.: 8409
Subfile: INDEX MEDICUS
We studied the effect of changes in the arterial tensions of oxygen and carbon dioxide on blood flow to the retinal (RBF) and choroidal ( ChBF ) capillary beds in 20 lambs. One to three days after placement of catheters in the left ventricle, abdominal aorta, and brachiocephalic artery, different gas mixtures were delivered to a bag enclosing the lamb's head. One group of lambs was studied at normal and low oxygen tensions while normocarbic, and another group was studied at normal and high carbon dioxide tensions while normoxic. RBF and ChBF were measured using the radioactive microsphere technique. RBF increased as PaO2 and, thus, arterial oxygen content [ ( O2]a) ?ell; in contrast, ChBF was not related to [O2]a. Oxygen delivery to the capillary bed of the retinal artery (i.e., RBF X [O2]a) was independent of arterial oxygen content because the change in [O2]a was balanced by a reciprocal change in RBF. Oxygen delivery to the choroidal capillary bed, however, rose with [O2]a because there was no reciprocal decrease in ChBF . Both RBF and ChBF increase as arterial carbon dioxide tension rose. Although an increase in arterial carbon dioxide tension produced an increase in RBF with no change in [O2]a, oxygen delivery to the retinal capillaries rose. Similarly, oxygen delivery to the capillaries of the choroid rose with carbon dioxide tension. Oxygenation of retinal tissue, which depends on oxygen diffusion from both the retinal and choroidal capillary beds, may change with variations in arterial oxygen content (increase in oxygen delivered to the choroidal capillary bed or arterial carbon dioxide tension (increase in oxygen delivered to both the retinal and choroidal capillary beds.
Tags: Animal; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.
Desc.: Animals, Newborn; *Anoxia--Physiopathology (PP); Blood Circulation; Carbon Dioxide--Blood (BL); *Choroid--Blood Supply (BS); *Hypercapnia--Physiopathology (PP); Oxygen--Blood (BL); *Retinal Artery--Physiology (PH); *Retrolental Fibroplasia--Etiology (ET); Sheep
CAS Registry No.: 7782-44-7 (Oxygen)

Y015154 71
1370032 84210032
[Retinopathy of prematurity--updated]
Shohat M; Nissenkorn I; Orpaz D; Reisner SH
Harefuah (ISRAEL), Feb 15 1984, 106 (4) p170-3,
ISSN 0017-7768
Jrnl Code: FZF 
Lang.: HEBREW
Jrnl Ann.: 8409
Subfile: INDEX MEDICUS
Tags: Human
Desc.: Infant, Newborn; *Retrolental Fibroplasia--Prevention and Control (PC)

Y015154 72
1362329 84202329
Retinopathy of prematurity: vitamin E.
Mayes LE Jr
Ariz Med (US), Mar 1984, 41 (3) p174-6,
ISSN 0004-1556
Jrnl Code: 8N6
Lang.: ENG.
Jrnl Ann.: 8408
Subfile: INDEX MEDICUS
Tags: Human
Desc.: Infant, Newborn; *Retrolental Fibroplasia--Drug Therapy (DT) ; Retrolental Fibroplasia--Metabolism (ME); Vitamin E--Metabolism (ME); *Vitamin E--Therapeutic Use (TU)
CAS Registry No.: 1406-18-4 (Vitamin E)

Y015154 73
1353855 84193855
[Risk of damage to the organ of vision in low birth weight infants]
Ryzyko uszkodzenia arzadu wzroku u dzieci urodzonych z niskim cie.ANG.zarem ciaLa.
Hofman H; Krzyzanowska J
Instytut Matki i Dziecka.
Probl Med Wieku Rozwoj (POLAND), 1979, 9 p55-61,
ISSN 0303-2264
Jrnl Code: PPS
Lang.: POLISH
Summary Lang.: ENG.
Doc. Type: English Abstract
Jrnl Ann.: 8408
Subfile: INDEX MEDICUS
The authors presented their own material of years 1974-1977. During this period 8788 children were born, in it ?37 (8, 3%) with low birth weight (below 2500 g). Retrolental fibroplasia was diagnosed in 4 children, it was 0, 5% of newborns with low birth weight, and 0, 04% of the all live-borns. The retrolental fibroplasia was diagnosed in: 1) the child born in 27 week of pregnancy with 1000 g of body weight, 2) in two children born in 32-33 week of pregnancy with 1450 g and 1350 g of body weight, 3) in a child born in 31 week of pregnancy with 1600 g of body weight. The infants were nursed in incubators with about 30% of oxygen during 36 to 46 days. Contemporary hypoglycemia, hypoproteinemia, atelectasia of lungs with respiratory insufficiency were diagnosed. In the discussion the authors underlined the role of immaturity and hypoxia of the premature baby, which play the role in the secondary injury of vessel's walls of retina. The disturbancy of carbohydrate and protein metabolism were certainly secondary pathogenic agent sin retrolental fibroplasia. There exists the necessity of oxygen therapy of premature baby, but to take cre of the infant in the incubator does not mean the necessity of oxygen therapy . Even with controlled oxygen dosage in incubator the retrolental fibroplasia may occur as a result of relative hyperoxydation induced by the constriction of retina vessels. The authors underlined the necessity of repeated ophthalmologic examination of premature babies in about every 2 weeks, what makes very early diagnosis possible.
Tags: Case Report; Female; Human; Male; Support, Non-U.S. Gov't
Desc.: Child, Preschool; Fetal Anoxia--Complications (CO); Hypoglycemia--Complications (CO); Hypoproteinemia--Complications (CO); Infant; *Infant, Low Birth Weight; *INFANT LBW; Infant, Newborn; Oxygen Inhalation Therapy--Adverse Effects (AE); Pregnancy; PREGN; Respiratory Distress Syndrome--Complications (CO); Respiratory Distress Syndrome--Therapy (TH); Retina--Metabolism (ME); *Retrolental Fibroplasia--Etiology (ET); Retrolental Fibroplasia--Occurrence (OC); Risk

Y015154 74
1352964 84192964
Vitamin E effect questioned [letter]
Gole GA; Skinner JM; Henderson DW; Mukherjee TM
Pediatrics (US), May 1984, 73 (5) p734-6,
ISSN 0031-4005
Jrnl Code: OXV
Lang.: ENG.
Jrnl Ann.: 8408
Subfile: AIM; INDEX MEDICUS
Tags: Human
Desc.: Cryosurgery; Infant, Newborn; Intercellular Junctions; *Retrolental Fibroplasia--Pathology (PA); Retrolental Fibroplasia--Therapy (TH); *Vitamin E--Therapeutic Use (TU)
CAS Registry No.: 1406-18-4 (Vitamin E)

Y015154 75
1352488 84192488
Lensectomy for secondary angle-closure glaucoma in advanced cicatricial retrolental fibroplasia.
Pollard ZF
Ophthalmology, Apr 1984, 91 (4) p395-8,
ISSN 0161-6420
Jrnl Code: OI5?
Lang.: ENG.
Jrnl Ann.: 8408
Subfile: INDEX MEDICUS
A study of 15 patients with secondary angle-closure glaucoma associated with advanced cicatricial retrolental fibroplasia is presented. Eight patients developed glaucoma acutely, while 7 showed a chronic course. In four patients the fellow eye became involved acutely within 1 month of the first eye. Seven others were also bilateral, but on a chronic basis. Twelve of the 15 presented after age 2. All were treated with lensectomy which cured the glaucoma. All have extremely poor vision in the range of light perception to hand motion, but have retained their eyes on a pain-free basis.
Tags: Case Report; Female; Human; Male; Support, Non-U.S. Gov't
Desc.: Cataract Extraction; *Cicatrix--Complications (CO); *Glaucoma--Surgery (SU); Infant; Intraocular Pressure; Iris--Surgery (SU); *Lens, Crystalline--Surgery (SU); *Retrolental Fibroplasia--Complications (CO); Visual Acuity; Vitreous Body--Surgery (SU)

Y015154 76
1341330 84181330
Care of the infant with retinopathy of prematurity.
Porat R
Division of Neonatology, Albert Einstein Medical Center, Philadelphia, Pennsylvania.
Clin Perinatol (US), Feb 1984, 11 (1) p123-51,
ISSN 0095-510?
Jrnl Code: DHH
Lang.: ENG.
Doc. Type: Review
Jrnl Ann.: 8408
Subfile: INDEX MEDICUS (108 Refs.)
Tags: Female; Human; Male
Desc.: Blindness--Psychology (PX); Child Development; Child; Child, Preschool; Cryosurgery; Fluorescein Angiography; Fundus Oculi; Infant; Infant, Low Birth Weight; INFANT LBW; Infant, Newborn; Light Coagulation; Retrolental Fibroplasia--Complications (CO); *Retrolental Fibroplasia--Diagnosis (DI); Retrolental Fibroplasia--Etiology (ET); Retrolental Fibroplasia--Therapy (TH); Risk; Scleral Buckling; Vision Disorders--Etiology (ET); Vitamin E--Therapeutic Use (TU); Vitrectomy
CAS Registry No.: 1406-18-4 (Vitamin E)

Y015154 77
1336601 84176601
Oxygen and retrolental fibroplasia: update and challenge [editorial]
Flynn JT
Anesthesiology (US), May 1984, 60 (5) p397-9,
ISSN 0003-3022
Jrnl Code: 4SG
Contract/Grant No.: EY03513
Lang.: ENG.
Jrnl Ann.: 8407
Subfile: AIM; INDEX MEDICUS 
Tags: Comparative Study; Human; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.
Desc.: *Anesthesia, Inhalation--Adverse Effects (AE); Birth Weight Infant, Newborn; *Infant, Premature; *Infant, Premature, Diseases--Surgery (SU); *Oxygen--Adverse Effects (AE); *Retrolental Fibroplasia--Etiology (ET); Risk
CAS Registry No.: 7782-44-7 (Oxygen)

Y015154 78
1335206 84175206
The effect of vitamin E on erythrocyte hemolysis and lipid peroxidation in newborn premature infants.
Cruz CS; Wimberley PD; Johansen K; Friis-Hansen B
Dept. of Neonatology, Rigshospitalet, Copenhagen, Denmark.
Acta Paediatr Scand (SWEDEN), Nov 1983, 72 (6) p823-6,
ISSN 0001-65?X
Jrnl Code: 1LV
Lang.: ENG.
Jrnl Ann.: 8407
Subfile: INDEX MEDICUS
The biochemical effect of vitamin E supplementation to mothers with threatened premature delivery and to premature infants after birth has been studied. Although a weak correlation was found between maternal and cord blood vitamin E levels at birth, cord blood levels were not significantly higher in the infants from supplemented mothers than those from unsupplemented mothers. Furthermore, maternal vitamin E treatment did not prevent either erythrocyte hemolysis or lipid peroxide formation in the premature infants after birth. On the other hand, intramuscular vitamin E to infants after birth produced a marked biochemical effect, with both zero erythrocyte hemolysis and low lipid peroxide formation when serum vitamin E increased above 2 mg/100 ml. We conclude that intramuscular vitamin E immediately after birth is necessary to achieve a biochemical effect of vitamin E in the early neonatal period. (No cases of retrolental fibroplasia occurred in the present study.)
Tags: Female; Human
Desc.: Erythrocytes--Metabolism (ME); Fatal Blood--Metabolism (ME) *Hemolysis--Drug Effects (DE); Infant, Newborn; *Infant, Premature; *Lipid Peroxides--Blood (BL); Maternal-Fetal Exchange; Pregnancy; PREGN; *Vitamin E--Administration and Dosage (AD); Vitamin E--Blood (BL)
CAS Registry No.: 1406-18-4 (Vitamin E)

Y015154 79
1313444 84153444
Sequelae of arrested mild retinopathy of prematurity.
Schaffer DB; Quinn GE; Johnson L
Division of Ophthalmology, Children's Hospital of Philadelphia, PA.
Arch Ophthalmol (US), Mar 1984, 102 (3) p373-6,
ISSN 0003-9950
Jrnl Code: 830
Contract/Grant No.: RO1 EY 01723
Lang.: ENG.
Jrnl Ann.: 8406
Subfile: AIM; INDEX MEDICUS
Twenty-six infants with totally resolved low-grade retinopathy of prematurity (ROP) were compared with a similar group of 38 premature infants in whom no retinopathy had ever developed in the nursery. At the examination performed at a physiologic age of 1 year, the two groups were almost indistinguishable with respect to their refractive errors, strabismus, and amblyopia. The incidence and severity of mild to moderate anisometropia was increased in the resolved ROP group. It appears that there is a group of infants in whom absolute resolution occurs, with few residua of active ROP. This is especially true when there are no anatomical retinal findings consistent with low-grade cicatricial retrolental fibroplasia at 1 year of age.
Tags: Comparative Study; Human; Support, U.S. Gov't, P.H.S.
Desc.: Amblyopia--Etiology (ET); Follow-Up Studies; Infant; Infant, Newborn; Infant, Premature; Myopia--Etiology (ET); Refractive Errors--Etiology (ET); *Retrolental Fibroplasia--Complications (CO); Retrolental Fibroplasia--Physiopathology (PP); Strabismus--Etiology (ET)

Y015154 80
1313443 84153443
Angle-closure glaucoma in adults with cicatricial retinopathy of prematurity.
Smith J; Shivitz I
Arch Ophthalmol, Mar 1984, 102 (3) p371-2,
ISSN 0003-9950
Jrnl Code: 830
Lang.: ENG.
Jrnl Ann.: 8406
Subfile: AIM; INDEX MEDICUS
Acute angle-closure glaucoma developed in three adults who were being followed up for stable cicatricial retinopathy of prematurity. After medical therapy succeeded in breaking the attack of angle-closure glaucoma, two of the patients were treated with surgical peripheral iridectomy and one patient was treated by argon laser iridotomy. All three of the patients had stabilization of their intraocular pressure and preservation of their visual acuity during follow-up of 2 1/2 to five years' duration.
Tags: Case Report; Female; Human
Desc.: Adult; *Cicatrix--Complications (CO); *Glaucoma--Etiology (ET); Glaucoma--Surgery (SU); Iris--Surgery (SU); Lasers--Therapeutic Use (TU); *Retrolental Fibroplasia--Complications (CO)

Y015154 81
1303911 84143911
Vitamin E and necrotizing enterocolitis.
Finer NN; Peters KL; Hayek Z; Merkel CL
Pediatrics, Mar 1984, 73 (3) p387-93,
ISSN 0031-4005
Jrnl Code: OXV
Lang.: ENG.
Jrnl Ann.: 8406
Subfile: AIM; INDEX MEDICUS
Although vitamin E has been shown to reduce the incidence of severe sequelae from retrolental fibroplasia, there have been recent suggestions that its use may be associated with an increased incidence of necrotizing enterocolitis (NEC). A review was made of experience with vitamin E, both intramuscular and oral, and NEC over a 4 1/2-year period. Of 418 infants of birth weight less than 1, 500 g admitted during this period, 28/209 infants who had received vitamin E had definite NEC (13.4%) compared with 12/209 who had not received vitamin E (5.74%, chi 2 = 7.07, P = .008). For infants of birth weight less than 1, 250 g, 16/103 infants who received vitamin E developed NEC v 1/159 who had not (chi 2 = 21.1, P less than .001); the incidence of NEC was not significantly different between the two groups for infants with birth weight between 1, 250 to 1, 500 g. The early mortality (less than seven days) for infants with birth weight of 1, 500 g or less was significantly greater for those who had not received vitamin E (43.5% v 13.8%, chi 2 = 44.9, P less than .001), most probably a reflection of the omission of this drug for the most critically ill infants in this retrospective review. The incidence of NEC was not different for infants with birth weight of 1, 500 g or less who received intramuscular vitamin E compared with control infants from the same period. For those infants for whom serum tocopherol levels were available, no infant who developed NEC and who had received only oral vitamin E had a serum tocopherol levels of greater than 3.5 mg/100 mL. (ABSTRACT TRUNCATED AT 250 WORDS)
Tags: Comparative Study; Human
Desc.: Administration, Oral; Dose-Response Relationship, Drug; DOSE RESPONSE RELAT DRUG; Enterocolitis, Pseudomembranous--Blood (BL); *Enterocolitis, Pseudomembranous--Chemically Induced (CI); Follow-Up Studies; Infant; *Infant, Low Birth Weight; *INFANT LBW; Infant, Newborn; *Retrolental Fibroplasia--Drug Therapy (DT); *Vitamin E--Adverse Effects (AE); Vitamin E--Blood (BL); Vitamin E--Therapeutic Use (TU)
CAS Registry No.: 1406-18-4 (Vitamin E)

Y015154 82 
1296048 84136048
Prevention and management of retrolental fibroplasia.
Hittner HM; Kretzer FL; Rudolph AJ
Dept. of Pediatrics, Baylor College of Medicine, Houston.
Hosp Pract [Off] (US), Feb 1984, 19 (2) p85-94, 99,
Jrnl Code: HPO
Lang.: ENG.
Jrnl Ann.: 8406
Subfile: AIM; INDEX MEDICUS
Tags: Human
Desc.: Double-Blind Method; Infant, Newborn; Infant, Premature; Ophthalmoscopy; Retinal Vein--Pathology (PA); Retrolental Fibroplasia--Etiology (ET); Retrolental Fibroplasia--Pathology (PA); *Retrolental Fibroplasia--Prevention and Control (PC); Vitamin E--Administration and Dosage (AD); *Vitamin E--Therapeutic Use (TU)
CAS Registry No.: 1406-18-4 (Vitamin E)

Y015154 83 
1285519 84125519
Retrolental fibroplasia in full-term infants without exposure to supplemental oxygen.
Kushner BJ; Gloeckner E
Pediatric Eye Clinic, Univ. of Wisconsin, Madison.
Am J Ophthalmol (US), Feb 1984, 97 (2) p148-53,
ISSN 0002-9394
Jrnl Code: 3OQ
Lang.: ENG.
Jrnl Ann.: 8405
Subfile: AIM; INDEX MEDICUS
We observed retinal folds identical in appearance to Grade 3 cicatricial retrolental fibroplasia in three infants at birth. In two of them we observed the active lesion of acute retrolental fibroplasia in the fellow eye at birth. These observations lead us to suggest that the active legion of retrolental fibroplasia can occur in utero and progress to cicatrization in the absence of any obvious precipitating factor.
Tags: Case Report; Human; Male
Desc.: Diagnosis, Differential; DIAG DIFFER; Infant, Newborn; Neovascularization--Etiology (ET); Retina--Abnormalities (AB); Retina--Blood Supply (BS); *Retrolental Fibroplasia--Diagnosis (DI); Retrolental Fibroplasia--Etiology (ET)

Y015154 84 
1285505 84125505
Ocular vasodilation and angiogenesis in Potter's syndrome.
Rotberg M; Klintworth GK; Crawford JB
Dept. of Ophthalmology, Duke Univ. Medical Center, Durham, North Carolina.
Am J Ophthalmol (US), Jan 1984, 97 (1) p16-31,
ISSN 00?2-9394
Jrnl Code: 3OQ
Contract/Grant No.: 1RO1-EYO 147
Lang.: ENG.
Jrnl Ann.: 840
Subfile: AIM; INDEX MEDICUS
At autopsy we examined eight eyes of six infants with Potter's syndrome, an i?iopathic multisystem condition with a constellation of ocular anomalies, to explore its ocular component more fully and systematically. A striking abnormality in some cases was the presence of dilated intraocular blood vessels, and these were sometimes associated with retinal and preretinal neovascularization reminiscent of the vasoproliferative stage of retrolental fibroplasia. Since oxygen therapy cannot be implicated in these cases, other causes, either genetic or environmental, must be sought. The presence of nonretinal ocular vascular anomalies, such as iris capillary dilation, peripapillary angioma formation, and vascular anomalies in nonocular tissue, point to a generalized derangement in the control of ocular angiogenesis. Our study indicated that an understanding of the pathogenesis of the vascular anomalies in Potter's syndrome is clearly relevant to other more common retinopathies that are associated with neovascularization.
Tags: Case Report; Human; Male; Support, U.S. Gov't, P.H.S.
Desc.: Abnormalities, Multiple--Pathology (PA); Dilatation, Pathologic--Congenital (CN); Dilatation, Pathologic--Pathology (PA); *Eye--Abnormalities (AB); Eye--Blood Supply (BS); Infant, Newborn; Kidney--Abnormalities (AB); Kidney--Pathology (PA); Neovascularization--Congenital (CN); *Neovascularization--Pathology (PA); *Retinal Vessels--Abnormalities (AB); Retinal Vessels--Pathology (PA); Syndrome

Y015154 85 
1278537 84118537
Retrolental fibroplasia and vitamin E in the preterm infant--comparison of oral versus intramuscular: oral administration.
Hittner HM; Speer ME; Rudolph AJ; Blifeld C; Chadda P; Holbein ME; Godio LB; Kretzer FL
Cullen Eye Institute, Baylor College of Medicine, Houston, TX.
Pediatrics (US), Feb 1984, 73 (2) p238-49,
ISSN 0031-4005
Jrnl Code: OXV
Contract/Grant No.: EY 02607
Lang.: ENG.
Jrnl Ann.: 8415
Subfile: AIM; INDEX MEDICUS
To evaluate the efficacy of four early intramuscular injections of vitamin E given in addition to continuous minimal oral vitamin E supplementation, 168 very low-birth-weight infants (less than or equal to 1, 500 g) have enrolled in a randomized, double-masked, clinical study. All infants received vitamin E orally, 100 mg/kg/d. In addition, on days 1, 2, 4, and 6, seventy-nine infants received vitamin E intramuscularly, 15, 10, 10, and 10 mg/kg, respectively. On the same days, 89 control infants received placebo intramuscular injections. Multivariate analysis of the 135 infants who survived greater than or equal to 10 weeks showed no significant difference in the development of severe retrolental fibroplasia between these two supplementation schedules (P = .86). Plasma vitamin E levels never exceeded a mean of 3.3 mg/100 mL, and no toxicity was observed. Ultrastructural analyses of seven pairs of whole eye donations from infants receiving IM vitamin E demonstrated identical kinetics of gap junction formation between adjacent spindle cells as compared with 13 pairs of whole eye donations from control infants (P greater than .3). Therefore, oral vitamin E supplementation affords retinal protection against the development of severe retrolental fibroplasia when initiated on the first day of life and maintained continuously until retinal vascularization is complete.
Tags: Human; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S. 
Desc.: Administration, Oral; Infant, Newborn; Infant, Premature; Injections, Intramuscular; Microscopy, Electron; Retina--Pathology (PA); Retrolental Fibroplasia--Pathology (PA); *Retrolental Fibroplasia--Prevention and Control (PC); Time Factors; *Vitamin E--Administration and Dosage (AD); Vitamin E--Therapeutic Use (TU)
CAS Registry No.: 1406-18-4 (Vitamin E)

Y015154 86 
1275835 84115835
[The ophthalmologist's role in the prevention of retrolental fibroplasia]
Rola okulisty w profilaktyce zwLoknienia pozasoczewkowego.
Prost M
Klin Oczna (POLAND), Oct 1983, 85 (10) p367-9,
ISSN 0023-2157
Jrnl Code: KWC
Lang.: POLISH
Summary Lang.: ENG.
Doc. Type: English Abstract
Jrnl Ann.: 8405
Subfile: INDEX MEDICUS
Tags: Human
Desc.: Age Factors; Child, Preschool; Follow-Up Studies; Fundus Oculi; Infant; Infant, Newborn; *Ophthalmology; Ophthalmoscopy; *Physician's Role; Retrolental Fibroplasia--Diagnosis (DI); *Retrolental Fibroplasia--Prevention and Control (PC); *Role; Time Factors

Y015154 87 
1274119 84114119
Indomethacin and retrolental fibroplasia [letter]
Flower RW
J Pediatr (US), Feb 1984, 104 (2) p326,
ISSN 0022-3476
Jrnl Code: JLZ
Lang.: ENG.
Jrnl Ann.: 8405
Subfile: AIM; INDEX MEDICUS
Tags: Human
Desc.: *Indomethacin--Therapeutic Use (TU); Infant, Newborn; *Infant, Premature; *Retrolental Fibroplasia--Drug Therapy (DT)
CAS Registry No.: 53-86-1 (Indomethacin)

Y015154 88 
1262846 84102846
Asymmetry in retrolental fibroplasia.
Rollard ZF
Ann Ophthalmol, Aug 1983, 15 (8) p768-71,
ISSN 0003-4886
Jrnl Code: 5PA
Lang.: ENG.
Jrnl Ann.: 8404
Subfile: INDEX MEDICUS
Ten cases of asymmetry in retrolental fibroplasia vary from patients with unilateral to those with bilateral involvement. In the bilateral cases, one eye was always more severely affected. This article encourages the treatment of amblyopia when present in patients with retinopathy of prematurity.
Tags: Case Report; Female; Human; Male
Desc.: *Amblyopia--Complications (CO); Amblyopia--Therapy (TH); Child; Child, Preschool; Gestational Age; Glaucoma--Complications (CO); Infant; Infant, Low Birth Weight; INFANT LBW; Infant, Newborn; Retinal Detachment--Complications (CO); Retrolental Fibroplasia--Complications (CO) ; *Retrolental Fibroplasia--Diagnosis (DI)

Y015154 89 
1262830 84102830
The relationship of blood transfusions to retrolental fibroplasia.
Mittelman D; Cronin C
Dept. of Ophthalmology, Loyola Univ. Stritch School of Medicine, Maywood, Ill.
Ann Ophthalmol (US), Apr 1983, 15 (4) p376-8,
ISSN 0003-4886
Jrnl Code: 5PA
Lang.: ENG.
Jrnl Ann.: 8404
Subfile: INDEX MEDICUS
The medical records of 53 premature infants weighing less than 1, 360 g at birth were examined. The retinas of 32 infants remained normal, while mild active retrolental fibroplasia developed in 17 babies, and severe active retrolental fibroplasia developed in four babies. The birth weight, duration of exposure of supplemental oxygen, and the amount of blood they received as transfusions were recorded. There was no significant difference in these values for those babies those retinas remained normal and for those babies in whom mild retinopathy of prematurity developed. However, the infants in whom severe retrolental fibroplasia developed were significantly smaller in weight at birth and received more supplemental oxygen and transfused blood. There was a close correlation between the amount of blood transfused and days of exposure to supplemental oxygen. In addition, the ratio of transfused blood to days of supplemental oxygen exposure was greater in those infants in whom no retrolental fibroplasia developed and least in those infants in whom severe active retrolental fibroplasia developed.
Tags: Human
Desc.: Birth Weight; *Blood Transfusion--Adverse Effects (AE); Infant, Newborn; Oxygen Inhalation Therapy--Adverse Effects (AE); Regression Analysis; *Retrolental Fibroplasia--Etiology (ET); Risk

Y015154 90 
1261093 84101093
[A new score for the evaluation of retinopathy in premature infants. IV. 50 cases of retinopathy type I and II]
Karaki T; Horiguchi M; Ohta I; Miyake S
Nippon Ganka Gakkai Zasshi (JAPAN), 1983, 87 (9) p684-90,
ISSN 0029-0203
Jrnl Code: 22O
Lang.: JAPANESE
Summary Lang.: ENG.
Doc. Type: English Abstract
Jrnl Ann.: 8404
Subfile: INDEX MEDICUS
Tags: Female; Human; Male
Desc.: Infant, Newborn; Japan; *Retrolental Fibroplasia--Occurrence (OC)

Y015154 91 
1259919 84099919
[Cardiovascular function, hemodynamics and tissue O2 supply in the neonatal period--relation to retinopathy in premature animals]
Kardiovaskulare Funktion, Hamodynamik und Gewebs-O2-Versorgung in der Neonatalperiode--Beziehungen zur Retinopathia praematurorum]
Menzel K; Buchenau W; Nissel C
Neonatalogiche Abteilung der Kinderklinik, Medizinischen Akademie Erfurt.
Z Arztl Fortbild (Jena) (GERMANY, EAST), 1983, 77 (20) p845-8,
ISSN 0044-2178
Jrnl Code: XS6
Lang.: GERMAN
Jrnl Ann.: 8404
Subfile: INDEX MEDICUS
Tags: Animal
Desc.: Animals, Newborn; Anoxia--Physiopathology (PP); Blood Pressure; *Cardiovascular System--Physiology (PH); Heart Rate; *Hemodynamics; *Oxygen Consumption; *Retrolentar Fibroplasia--Etiology (ET) ; Swine

Y015154 92 
1254753 84094753
A reexamination of the role of oxygen in retrolental fibroplasia.
Lucey JF; Dangman B
Pediatrics, Jan 1984, 73 (1) p82-96,
ISSN 0031-4005
Jrnl Code: OXV?e:
Lang.: ENG.
Doc. Type: Review
Jrnl Ann.: 8404
Subfile: AIM; INDEX MEDICUS
A critical review of the literature of retrolental fibroplasia indicates that the cause of this disease is not yet known. Oxygen is certainly a critical factor but it is still not possible to make precise recommendations as to the amount or the duration of therapy that is safe. We have overemphasized the role of oxygen in the past, and as a result of this the false impression has been created that RLF is a disease that can be prevented. This gross oversimplification of a complex disease with multiple causes has resulted in many unjustified malpractice claims. A study of the present epidemic indicates that excessive oxygen administration probably plays a minor role, in contrast to the first epidemic in which prolonged oxygen administration was clearly a major facter. A reasonable working hypothesis is that the developing retina is highly sensitive to any disturbance in its oxygen supply, either hyperoxemic or hypoxemic. The retinal circulation is subject to the same wide fluctuations as the cerebral circulation in newborn infants. The very low-birth-weight, sick premature infant suffers from a number of conditions, many of which can seriously disturb the retinal circulation, resulting in hypoper?usion and ischemia. These factors (immaturity, hyperoxia, hypoxia, blood transfusions, intraventricular hemorrhage, apnea, infection, hypercarbia, hypocarbia, patent ductus arteriosus, prostaglandin synthetase inhibitors, vitamin E deficiency, lactic acidosis, prenatal complications, genetic factors) may all be present in an infant. They may interact to produce various degrees of retinal damage. Nearly all of these factors cannot be prevented or controlled by our present methods of care. Unfortunately, this means that RLF is an extremely difficult disease to prevent treat, or investigate. A disease of this complexity with multiple causes will require very large numbers of infants in any controlled study of a therapy. Retrolental fibroplasia should not be considered an avoidable iatrogenic disease in very low-birth-weight infants. Its cause in these infants is not known. (134 Refs.)
Tags: Female; Human
Desc.: Anencephaly--Complications (CO); Anoxia--Complications (CO) Apnea--Complications (CO); Carbon Dioxide--Physiology (PH); Cerebral Hemorrhage--Complications (CO); Ductus Arteriosus, Patent--Complications (CO); Exchange Transfusion, Whole Blood--Adverse Effects (AE); EXCHANGE TRANSFUSION--Adverse Effects (AE); Heart Defects, Congenital--Complications (CO); Indomethacin--Adverse Effects (AE); Infant, Newborn; Lactates--Metabolism (ME); *Oxygen--Adverse Effects (AE); Pregnancy; PREGN Pregnancy Complications; PREGN COMPL; Prostaglandins--Physiology (PH); Retinal Diseases--Complications (CO); *Retrolental Fibroplasia--Etiology (ET); Superoxide Dismutase--Deficiency (DF); Vitamin E Deficiency--Complications (CO)
CAS Registry No.: 50-21-5 (lactic acid); 53-8?-1 (Indomethacin); 7782-44-7 (Oxygen) Enzyme No.: EC 1.15.1.1 (Superoxide Dismutase)

Y015154 93 
1254445 8409444
Retinopathy of prematurity: a new look at an old disease.
Wolbarsht ML; George GS; Shearin WA Jr; Kylstra JA; Landers MB 3d
Dept. of Ophthalmology, Duke Univ. Medical Center, Durham, North Carolina.
Ophthalmic Surg (US), Nov 1983, 14 (11) p919-24,
ISSN 0022-023X
Jrnl Code: OIC
Contract/Grant No.: 5 732 GM07171
Lang.: ENG.
Jrnl Ann.: 8404
Subfile: INDEX MEDICUS
The neovascular changes of the retinopathy of prematurity can occur in premature infants in three settings: (1) when high levels of supplemental oxygen are administered, neovascularization usually commences shortly after cessation of oxygen therapy; (2) when supplemental oxygen is given for long periods of time, neovascularization can develop while the infant is still receiving oxygen; and (3) neovascularization can occur without exposure to any supplemental oxygen. We propose a model which can explain the occurrence of the retinopathy of prematurity in all these settings. Our model demonstrates that whenever the retinopathy of prematurity occurs, arterial oxygen levels are inappropriately high in relation to the stage of retinal vessel development, even in premature neonates not given supplemental oxygen. The inhibitory effect of these elevated oxygen tensions upon carbon dioxide removal is indicated as a possible cause of neovascularization by leading to tissue acidosis and vasodilatation.
Tags: Human; Support, U.S. Gov't, P.H.S.
Desc.: Carbon Dioxide--Blood (BL); Infant, Newborn; Models, Biological; Neovascularization--Physiopathology (PP); Oxygen--Blood (BL); Retinal Vessels--Physiopathology (PP); *Retrolental Fibroplasia--Etiology (ET); Retrolental Fibroplasia--Physiopathology (PP); Vasodilation
CAS Registry No.: 7782-44-7 (Oxygen)

Y015154 94 
1254444 84094444
Retinopathy of prematurity: a continuing problem [editorial]
Ellis FD
Ophthalmic Surg (US), Nov 1983, 14 (11) p911,
ISSN 0022-023X
Jrnl Code: OIC
Lang.: ENG.
Jrnl Ann.: 8404
Subfile: INDEX MEDICUS
Tags: Human
Desc.: Infant, Newborn; *Retrolental Fibroplasia--Etiology (ET)

Y015154 95 
1252642 84092642
Introductory comments for session V "neovasculogenesis" presented at the fifth symposium, the International Society on Metabolic Eye Disease October 24-26, 1982.
Waitzman MB
Laboratory for Ophthalmic Research, Emory Univ., Atlanta, Georgia.
Metab Pediatr Syst Ophthalmol (US), 1983, 7 (2) p71-4,
ISSN 0277-9382
Jrnl Code: MUF
Lang.: ENG.
Jrnl Ann.: 8404
Subfile: INDEX MEDICUS
Physiopathologic or metabolic alterations in retinal blood vessels resulting in an ischemic state may be a prime trigger mechanism in neovasculogenesis and scar tissue formation. Rate of oxygen delivery may be the primary factor so the end-state disease may be rapid as in retrolental fibroplasia (marked reduction in vascular flow due to acute vasoconstriction) or delayed as in diabetes mellitus (chronic metabolism-induced low oxygen release rates parallel with chronic vasodilation).
Tags: Animal; Human
Desc.: Diabetic Retinopathy--Etiology (ET); Diabetic Retinopathy--Metabolism (ME); Dogs; *Eye--Blood Supply (BS); Ischemia--Complications (CO); *Neovascularization; Neovascularization--Physiopathology (PP); Oxygen Consumption; Prostaglandins--Physiology (PH); Retrolental Fibroplasia--Etiology (ET); Retrolental Fibroplasia--Metabolism (ME); Vasoconstriction; Vasodilation

Y015154 96 
1243771 84083771
Vitamin E and retrolental fibroplasia: Ultrastructural mechanism of clinical efficacy.
Hittner HM; Kretzer FL
Cullen Eye Institute, Baylor College of Medicine, Houston, TX.
Ciba Found Symp (NETHERLANDS), 1983, 101 p165-85,
ISSN 0300-5208
Jrnl Code: D7X
Contract/Grant No.: EY-02607
Lang.: ENG.
Jrnl Ann.: 8404
Subfile: INDEX MEDICUS
Administration of control, oral or combined intramuscular and oral vitamin E to 418 high risk, preterm infants (1500 g or less birth weight; 32 weeks or less gestational age; 305 surviving more than 10 weeks) led to raised peak plasma levels of the vitamin of between 0.6 and 3.3 mg% in three consecutive clinical trials. This early, non-toxic, prophylactic supplementation suppressed the development of severe retrolental fibroplasia when the antioxidant was given continuously from the first day of life until retinal quiescence. Studies of 63 pairs of eyes by transmission electron microscopy revealed that spindle cells (the embryonic precursors of inner retinal capillaries) were the primary target of the vitamin E-induced suppression of severe retrolental fibroplasia. Extensive increases in the gap junctions between adjacent spindle cells in unsupplemented infants, or in supplemented infants of 27 weeks gestational age or less, triggered both neovascularization from the most nascent capillaries at the rearguard-vanguard retinal interface, and dilatation and tortuosity in the rearguard (posterior) retinal vessels. Continuous vitamin E supplementation permanently preserved the embryonic state of the spindle cells in infants of 28 weeks gestational age or more, and transiently retarded gap junction increases in infants of 27 weeks gestational age or less.
Tags: Comparative Study; Human; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.
Desc.: Clinical Trials; Eye--Blood Supply (BS); Eye--Drug Effects (DE); Eye--Ultrastructure (UL); Infant, Low Birth Weight; INFANT LBW; Infant, Newborn; Infant, Premature; Intercellular Junctions--Ultrastructure (UL); Microscopy Electron; *Retrolental Fibroplasia--Prevention and Control (PC); Vitamin E--Blood (BL); *Vitamin E--Therapeutic Use (TU)
CAS Registry No.: 1406-18-4 (Vitamin E)

Y015154 97 
1243770 84083770
Vitamin E and retrolental fibroplasia: prevention of serious ocular sequelae.
Finer NN; Peters KL; Schindler RF; Grant GD
Dept. of Newborn Medicine, Royal Alexandra Hospital, Edmonton, Alberta, Canada.
Ciba Found Symp (NETHERLANDS) 1983, 101 p147-64,
ISSN 0300-5208
Jrnl Code: D7X
Lang.: ENG.
Jrnl Ann.: 8404
Subfile: INDEX MEDICUS
In an attempt to determine the role of vitamin E in retrolental fibroplasia (RLF) we report our experience with 191 infants of less than 1500 g birth weight. Of these infants, 16.75% had evidence of acute RLF in hospital, 8.4% had ci?atricial RLF at follow-up, and four infants (2.1%) were blind, none of whom had received supplementary vitamin E. The incidence of cicatricial RLF at follow-up was significantly lower in infants who received vitamin E early after birth (12 h) than in those who did not (3 of 105 versus 13 of 86, X2 = 9.26, P = 0.002), as was the incidence of Grade III or greater cicatrix (0 of 105 versus 7 of 86, X2 with Yates = 6.72, P = 0.01). Stepwise multiple linear regression analysis revealed three factors distinguishing infants who developed cicatricial RLF from those who did not: the lack of early vitamin E supplements (P = 0.0023), the significantly larger number of arterial PO2 values over 100 mmHg (P = 0.0056), and the presence of an intraventricular haemorrhage (P = 0.0032). The incidence and severity of necrotizing enterocolitis was similar in infants who received vitamin E and in those who did not. It is recommended that vitamin E be given within the first 12 hours of birth to all infants of less than 1500 g who require supplementary oxygen.
Tags: Comparative Study; Human
Desc.: Administration, Oral; Blindness--Prevention and Control (PC) ; Clinical Trials; Infant, Low Birth Weight; INFANT LBW; Infant, Newborn; Injections, Intramuscular; Oxygen Inhalation Therapy--Adverse Effects (AE) *Retrolental Fibroplasia--Prevention and Control (PC); Vitamin E--Administration and Dosage (AD); Vitamin E--Blood (BL); *Vitamin E--Therapeutic Use (TU)
CAS Registry No.: 1406-18-4 (Vitamin E)

Y015154 98 
1243406 84083406
Cellular and subcellular vents in retinopathy of oxygen toxicity with a preliminary report on the preventive role of vitamin E and gamma-aminobutyric acid: a study in vitro.
Tripathi BJ; Tripathi RC
Eye Research Laboratories, Univ. of Chicago, IL.
Curr Eye Res (ENGLAND), Jan 1984, 3 (1) p193-208,
ISSN 0271-3683
Jrnl Code: DUB
Contract/Grant No.: EY-03747
Lang.: ENG.
Doc. Type: Review
Jrnl Ann.: 8404
Subfile: INDEX MEDICUS
Using freshly excised, pure, immature retinal vascular explants from neonatal rabbits as well as vascular cells harvested from such explants in a tissue culture environment, we established the direct cytocidal effect of hyperoxia on the vascular cells. One hundred percent oxygen at one atmosphere induced a marked cellular retraction after 4 to 6 hours of exposure and caused progressive increase in the number and size of lysosomal bodies and autophagic vacuoles. Between 12 to 18 hours, the Golgi apparatus enlarged and focal cytoplasmic degeneration ensued the various changes in the endoplasmic reticulum, mitochondria, and nucleus became apparent between 18 to 24 hours. After 36 to 48 hours continuous exposure to hyperoxia, the cellular degradation with nuclear pyknosis led to granular and membranous debris. In contrast, the macrophages in the same culture were more resistant to the effect of hyperoxia. Our findings suggest multiple loci for oxygen toxicity in immature retinal vessels and cultured vascular cells. We believe that the cellular retraction is mediated through the prostanoid cascade. The initial event in cytotoxicity of hyperoxia is probably membrane injury, especially of the lysosomal system. The generation of the hydroxyl free radical invokes specific injury to the lysosomes; severe cellular damage occurs due to increased autophagocytosis, probably compounded upon by the inhibition of membrane pumps in the cell and he resulting intracellular acidosis. Injury to cell organelles such as mitochondria, endoplasmic reticulum, and nucleus which occurs at later stages and contributes to the final cell degeneration, may be partly related to the hyperoxic insult. The addition of vitamin E or gamma-aminobutryic acid to the culture medium partially retarded the hyperoxic injury to the vascular cells. In short term experiments, no significant damage occurred with exposure to 30% oxygen. The fact that immature, and not the mature, retinal vascular cells are rapidly and adversery affected by hyperoxia probably entails that the former are deficient in free radical scavenging enzymes but a protective mechanism against oxygen toxicity is acquired with the developmental maturity of these cells. (86 Refs.)
Tags: Animal; Comparative Study; In Vitro; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.
Desc.: Capillaries--Ultrastructure (UL); Free Radicals; *GABA--Pharmacodynamics (PD); Lysosomes--Ultrastructure (UL); Microscopy, Electron; *Oxygen--Pharmacodynamics (PD); Rabbits; *Retina--Drug Effects (DE); Retina--Metabolism (ME); Retinal Vessels--Ultrastructure (UL); Retrolental Fibroplasia--Etiology (ET); *Vitamin E--Pharmacodynamics (PD)
CAS Registry No.: 1406-18-4 (Vitamin E); 56-12-2 (GABA); 7782-44-7 (Oxygen)

Y015154 99 
1243402 84083402
Current concepts of the effect of oxygen on the developing retina.
Patz A
Wilmer Ophthalmological Institute, Johns Hopkins Univ. and Hospital, Baltimore, MD.
Curr Eye Res (ENGLAND), Jan 1984, 3 (?) p159-63,
ISSN 0271-3683
Jrnl Code: DUB
Lang.: ENG.
Jrnl Ann.: 8404
Subfile: INDEX MEDICUS
The role of oxygen in the development of retrolental fibroplasia and the mechanism of oxygen changes in the developing retina are discussed. The primary effect of oxygen is one of Vascular closure and the secondary response, which occurs after removal from increased oxygen, is retinal neovascularization. A brief discussion of recent observations on the potential role of vitamin E in the prevention of retrolental fibroplasia is presented.
Tags: Animal; Comparative Study; Human
Desc.: Infant, Newborn; Mice; Models, Biological; Neovascularization; *Oxygen--Pharmacodynamics (PD); *Retina--Drug Effects (DE); Retinal Vessels--Drug Effects (DE); *Retrolental Fibroplasia--Etiology (ET); Retrolental Fibroplasia--Prevention and Control (PC); Vitamin E--Pharmacodynamics (PD)
CAS Registry No.: 1406-18-4 (Vitamin E); 7782-44-7 (Oxygen)

Y015154 100 
1241?16 84081016
Retinopathy of prematurity: screening of patients at risk.
Lamberts L; Dralands L; Missotten L; Leys A; Deblaere C; Eggermont E; Devlieger H; Casaer P; Snoeys E
Bull Soc Belge Ophtalmol, 1982, 203 p57-70,
ISSN 0081-0746
Jrnl Code: BYO
Lang.: ENG.
Jrnl Ann.: 8404
Subfile: INDEX MEDICUS
Tags: Female; Human; Male
Desc.: Gestational Age; Infant; Infant, Newborn; *Infant, Premature ; Mass Screening--Methods (MT); Remission, Spontaneous; *Retinal Diseases--Occurrence (OC); *Retrolental Fibroplasia--Occurrence (OC)

Y015154 101 
1241014 84081014
Ultrasonography in retinoblastoma suspected cases.
Goes F; De Wachter A
Bull Soc Belge Ophtalmol, 1982, 203 p35-45,
ISSN 0081-0746
Jrnl Code: BYO
Lang.: ENG.
Jrnl Ann.: 8404
Subfile: INDEX MEDICUS
Tags: Case Report; Female; Human; Male
Desc.: Cataract--Congenital (CN); Child, Preschool; Diagnosis, Differential; DIAG DIFFER; *Eye Neoplasms--Diagnosis (DI); Infant; Pupil; *Retinoblastoma--Diagnosis (DI); Retrolental Fibroplasia--Diagnosis (DI); *Ultrasonics--Diagnostic Use (DU); Vitreous Body--Abnormalities (AB)

Y015154 102 
1240339 84080339
Retinal neovascularisation: early contributions of Professor Michaelson and recent observations.
Patz A
Wilmer Ophthalmological Institute, Johns Hopkins Univ. and Hospital, Baltimore, Maryland.
Br J Ophthalmol (ENGLAND), Jan 1984, 68 (1) p42-6,
ISSN 0007-1161
Jrnl Code: AZK
Lang.: ENG.
Doc. Type: Current Biog-Obit; Historical Article
Jrnl Ann.: 8404
Subfile: INDEX MEDICUS
The late Professor I. C. Michaelson's pioneer contributions to the development and pathophysiology of the retinal vasculature have laid the groundwork for a generation of ophthalmic research scientists to pursue this exciting field of investigation. In more recent studies it has been found that, in diabetic retinopathy, branch vein occlusion, sickle cell retinopathy, and retrolental fibroplasia, retinal neovascularisation follows the development of retinal capillary closure. The capillary closure or nonperfusion has been demonstrated by fluorescein angiography. A working hypothesis to explain the clinical and experimental observations is that these areas of nonperfused retina are ischaemic or hypoxic and liberate a theoretical angiogenic or vasoproliferative substance which stimulates the development of retinal neovascularisation. In postulating this working hypothesis it is important to recognise, firstly, that this hypothesis remains to be proved, and, secondly, that retinal neovascularisation may develop from other stimuli such as intraocular inflammation where retinal ischaemia is not apparent.
Tags: Animal; Human; Support, Non-U.S. Gov't
Desc.: Angiogenesis Factor--Physiology (PH); Diabetic Retinopathy--Physiopathology (PP); Fluorescein Angiography; History of Medicine, 20th Cent.; Ischemia--Surgery (SU); Israel; Light Coagulation; Neovascularization--Etiology (ET); *Neovascularization--Physiopathology (PP); *Ophthalmology--History (HI); Retinal Diseases--Physiopathology (PP) *Retinal Vessels--Physiopathology (PP); Retinal Vessels--Surgery (SU)
Named Person: Michaelson IC

Y015154 103 
1229514 84069514
Retinal disorders of childhood.
Eller AW; Brown GC
Pediatr Clin North Am, Dec 1983, 30 (6) p1087-101,
ISSN 0031-3955
Jrnl Code: OUM
Lang.: ENG.
Jrnl Ann.: 8403
Subfile: AIM; INDEX MEDICUS
Included in this discussion of retinal disorders affecting infants and children are retrolental fibroplasia, diabetic retinopathy, sickle cell retinopathy, retinal detachment, retinal hemorrhages of neonates, macular disease, colobomas, ocular toxocariasis, and TORCH syndrome.
Tags: Human; Support, Non-U.S. Gov't
Desc.: Anemia, Sickle Cell--Complications (CO); Child; Child Abuse Child, Preschool; Coloboma--Diagnosis (DI); Diabetic Retinopathy--Diagnosis (DI); Eye Injuries--Complications (CO); Fluorescein Angiography; Infant; Infant, Newborn; Iris--Abnormalities (AB); Keratitis, Dendritic--Congenital (CN); Keratitis, Dendritic--Diagnosis (DI); Retinal Detachment--Congenital (CN); Retinal Detachment--Diagnosis (DI); *Retinal Diseases--Congenital (CN); Retinal Diseases--Diagnosis (DI); Retinal Diseases--Etiology (ET); Retrolental Fibroplasia--Diagnosis (DI); Toxocariasis--Complications (CO); Toxocariasis--Diagnosis (DI); Toxoplasmosis, Ocular--Congenital (CN); Toxoplasmosis, Ocular--Diagnosis (DI)

Y015154 104 
1211962 84051962
Incidence of retinopathy of prematurity in a tertiary newborn intensive care unit.
Campbell PB; Bull MJ; Ellis FD; Bryson CQ; Lemons JA; Schreiner RL
Arch Ophthalmol, Nov 1983, 101 (11) p1686-8,
ISSN 0003-9950 Jrnl Code 830
Lang.: ENG.
Jrnl Ann.: 8402
Subfile: AIM; INDEX MEDICUS
This study determined the incidence of retinopathy of prematurity (ROP) in 2, 958 admissions to the Newborn Intensive Care Unit of the James Whitcomb Riley Hospital for Children, Indianapolis, between January 1976 and December 1979. Among 2,484 survivors, acute ROP developed in 72 (2.9%); 60 (83%) of these newborns had birth weights of less than 1, 500 g. The incidence of acute ROP among survivors with birth weights of less than 1, 000 g (28%) was approximately three times that of the survivors with birth weights between 1, 001 and 1, 500 g (10.1%). The overall incidence of blindness was 4.5% of surviving infant less than 1, 000 g and .2% of those surviving with birth weights of 1, 000 to 1, 500 g. Evidence of the strong influence of immaturity and low birth weight on the risk of development of ROP is reaffirmed. Increasing survival of the most susceptible infants may be the factor contributing most to the overall incidence of ROP.
Tags: Human; Support, Non-U.S. Gov't
Desc.: Birth Weight; Gestational Age; Indiana; Infant Mortality; Infant, Low Birth Weight; INFANT LBW; Infant, Newborn; Intensive Care Units, Neonatal; *Retrolental Fibroplasia--Occurrence (OC)

Y015154 105 
1211675 84051675
[Cellular mechanisms of protection against oxygen toxicity. Implications in pediatrics]
Mecanismes cellulai?es de la protection contre la toxicite de l'oxygene. Implications en pediatrie.
Perret L; Dehan M
Service de Pediatrie et Reanimation Neonatales, Hopital Antoine-Beclere, Clamart.
Arch Fr Pediatr (FRANCE), Aug-Sep 1983, 40 (7) p585-95,
ISSN 0003-9764
Jrnl Code: 71Q
Lang.: FRENCH
Doc. Type: Review
Jrnl Ann.: 8402
Subfile: INDEX MEDICUS (71 Refs.)
Tags: Human
Desc.: *Cells--Metabolism (ME); Chemistry; Child; Down's Syndrome--Etiology (ET); *Free Radicals; Infant, Premature, Diseases--Etiology (ET); Lung Diseases--Etiology (ET); Methemoglobinemia--Etiology (ET); *Oxygen--Adverse Effects (AE); Oxygen--Metabolism (ME); Phagocytosis; Porphyria--Etiology (ET); Retrolental Fibroplasia--Etiology (ET)
CAS Registry No.: 7782-44-7 (Oxygen)

Y015154 106 
1210727 84050727
[Retinopathy of premature infants (retrolental fibroplasia)]
La retinopathie des prematures (fibroplasie retrolentale).
Fontaine M; Lombardo JC; Birkel P
Ann Pediatr (Paris) (FRANCE), Sep 1983, 30 (7) p483-7,
ISSN 0066-2097
Jrnl Code: 5UC
Lang.: FRENCH
Summary Lang.: ENG.
Doc. Type: English Abstract
Jrnl Ann.: 8402
Subfile: INDEX MEDICUS
Tags: Human
Desc.: France; Infant, Newborn; Retrolental Fibroplasia--Diagnosis (DI); *Retrolental Fibroplasia--Occurrence (OC)

Y015154 107 
1197376 84037376
[Mechanism of action of penicillamine D in the neonatal period]
Der Wirkungsmechanismus de D-Penicillamin in der Neonatalperiode.
Oroszlan G; Lakatos L; Karmazsin L
Kinderarztl Prax (GERMANY, EAST), Jul 1983, 51 (7) p333-7,
ISSN 0023-1495
Jrnl Code: KVD
Lang.: GERMAN
Summary Lang.: ENG.
Doc. Type: English Abstract
Jrnl Ann.: 8402
Subfile: INDEX MEDICUS
Tags: Animal; Human
Desc.: Age Factors; Birth Weight; Infant, Newborn; Jaundice, Neonatal--Drug Therapy (DT); *Penicillamine--Pharmacodynamics (PD); Rats; Retrolental Fibroplasia--Prevention and Control (PC)
CAS Registry No.: 52-67-5 (Penicillamine)

Y015154 108 
1196241 84036241
Retrolental fibroplasia.
Marta MR
J Ophthalmic Nurs Technol (US), Nov 1983, 2 (4) p154-6,
ISSN 0744-7132
Jrnl Code: J77
Lang.: ENG.
Jrnl Ann.: 8402
Subfile: Nursing
Tags: Female; Human; Male
Desc.: Adolescence; Adult; Child; Infant, Newborn; Parents--Education (ED); *Retrolental Fibroplasia--Classification (CL); Retrolental Fibroplasia--Therapy (TH)

Y015154 109 
1192205 84032205
Eye problems of prematurity - alert.
Wackerhagen M
J Arkansas Med Soc (US), Sep 1983, 80 (4) p177,
ISSN 0004-1858
Jrnl Code: HEV
Lang.: ENG.
Jrnl Ann.: 8402
Subfile: INDEX MEDICUS
Tags: Human
Desc.: Arkansas; Child; Child, Preschool; Infant; *Retrolental Fibroplasia--Occurrence (OC)

Y015154 110 
1190318 84030318
[Retinopathy of prematurity: new perspectives on its pathogenesis]
Fruhgeborenen-Retinopathie: Neue Erkenntnisse zur Pathogenese.
Koerner F; Bossi E
Fortschr Ophthalmol (GERMANY, WEST), 1983, 80 (4) p294-7,
ISSN 0723-8045
Jrnl Code: F5V
Lang.: GERMAN
Summary Lang.: ENG.
Doc. Type: English Abstract
Jrnl Ann.: 8402
Subfile: INDEX MEDICUS
Tags: Female; Human; Male
Desc.: ?horoid--Physiology (PH); Infant, Newborn; Infant, Premature ; *Oxygen--Adverse Effects (AE); Oxygen--Pharmacodynamics (PD); *Retinal Diseases--Etiology (ET); *Retinal Vessels--Drug Effects (DE); *Retrolental Fibroplasia--Etiology (ET)
CAS Registry No.: 7782-44-7 (Oxygen)

Y015154 111 
1178631 84018631
Observations on retinal neovascularization.
Patz A
Trans New Orleans Acad Ophthalmol (US), 1983, p82-8,
ISSN 0077-8605
Jrnl Code: WAG
Lang.: ENG.
Jrnl Ann.: 8401
Subfile: INDEX MEDICUS
Tags: Animal; Female; Human 
Desc.: Adult; Aged; *Angiogenesis Factor; Cats; Diabetic Retinopathy--Pathology (PA); Disease Models, Animal; Dogs; *Growth Substances; Ischemia--Physiopathology (PP); Mice; *Neovascularization--Physiopathology (PP); Retinal Diseases--Pathology (PA); *Retinal Diseases--Physiopathology (PP); *Retinal Vessels--Physiopathology (PP); Retrolental Fibroplasia--Physiopathology (PP)

Y015154 112 
1178607 84018607
Current concepts in retrolental fibroplasia.
Patz A
Trans New Orleans Acad Ophthalmol (US), 1983, p192-8,
ISSN 0077-8605
Jrnl Code: WAG
Lang.: ENG.
Jrnl Ann.: 8401
Subfile: INDEX MEDICUS
Tags: Human
Desc.: Child; Infant, Newborn; Infant, Premature; *Oxygen--Adverse Effects (AE); *Retrolental Fibroplasia--Etiology (ET); *Retrolental Fibroplasia--Prevention and Control (PC); *Vitamin E--Therapeutic Use (TU)
CAS Registry No.: 1406-18-4 (Vitamin E); 7782-44-7 (Oxygen)

Y015154 113 
1152216 83307216
[Iatrogenic detachment of the retina]
Decollement de retine iatrogene.
Turut P
Annee Ther Clin Ophtalmol, 1982, 33 p22-43,
ISSN 0301-4495 Jrnl Code 6DA
Lang.: FRENCH
Summary Lang.: ENG.
Doc. Type: English Abstract; Review
Jrnl Ann.: 8312
Subfile: INDEX MEDICUS (44 Refs.)
Tags: Human
Desc.: Cataract Extraction; Cornea--Surgery (SU); Glaucoma--Surgery (SU); Iatrogenic Disease; Miotics--Adverse Effects (AE); Oxygen--Adverse Effects (AE); Postoperative Complications; POSTOP COMPL; Retina--Surgery (SU); *Retinal Detachment--Etiology (ET); Retrolental Fibroplasia--Etiology (ET); Strabismus--Surgery (SU); Surgery, Operative--Adverse Effects (AE); Vitreous Body--Surgery (SU)
CAS Registry No.: 7782-44-7 (Oxygen)

Y015154 114 
1150328 83305328
[Retinopathy of prematurity: a new score for the evaluation of prematurity of infants (III)--is it effective to stimulate the globe by pressure]
Karaki T; Ohta I; Horiguchi M; Miyake S
Nippon Ganka Gakkai Zasshi (JAPAN), Jun 1983, 87 (6) p384-90,
ISSN 0029-0203
Jrnl Code: 22O
Lang.: JAPANESE
Summary Lang.: ENG.
Doc. Type: English Abstract
Jrnl Ann.: 8312
Subfile: INDEX MEDICUS
Tags: Human
Desc.: Infant, Low Birth Weight; INFANT LBW; Infant, Newborn; *Pressure; *Retrolental Fibroplasia--Prevention and Control (PC)

Y015154 115 
1150310 83305310
[Retinopathy of prematurity: a new score for the evaluation of prematurity of infants (II)--the usefulness of prematurity score P]
Karaki T; Horiguchi M; Ohta I
Nippon Ganka Gakkai Zasshi (JAPAN), 1983, 87 (4) p259-66,
ISSN 0029-0203
Jrnl Code: 22O
Lang.: JAPANESE
Summary Lang.: ENG.
Doc. Type: English Abstract
Jrnl Ann.: 8312
Subfile: INDEX MEDICUS
Tags: Human
Desc.: Analysis of Variance; Infant, Low Birth Weight; INFANT LBW; Infant, Newborn; Japan; *Retrolental Fibroplasia--Occurrence (OC)

Y015154 116 
1144383 83299383
A baby with retrolental fibroplasia.
Taylor J
Nurs Times (ENGLAND), Aug 31-Sep 6 1983, 79 (35) p22-3,
ISSN 0029-6589
Jrnl Code: O9U
Lang.: ENG.
Jrnl Ann.: 8312
Subfile: Nursing
Tags: Female; Human; Male
Desc.: *Community Health Nursing; Infant, Newborn; Parent-Child Relations; *Parents--Psychology (PX); *Retrolental Fibroplasia

Y015154 117 
1142512 83297512
Vitamin E in retrolental fibroplasia [letter]
Smith IJ; Buchanan MF; Goss I; Congdon PJ
N Engl J Med (US), Sep 15 1983, 309 (11) p669-70,
ISSN 0028-4793
Jrnl Code: NOW
Lang.: ENG.
Jrnl Ann.: 8312
Subfile: AIM; INDEX MEDICUS
Tags: Case Report; Human; Male
Desc.: *Calcinosis--Chemically Induced (CI); Infant, Newborn; Injections, Intramuscular; *Retrolental Fibroplasia--Prevention and Control (PC); Vitamin E--Administration and Dosage (AD); *Vitamin E--Adverse Effects (AE)
CAS Registry No.: 1406-18-4 (Vitamin E)

Y015154 118 
1121843 83276843
Retrolental fibroplasia.
Tasman W
Trans Pa Acad Ophthalmol Otolaryngol (US), Spring 1983, 36 (1) p9-13,
ISSN 0048-3206
Jrnl Code: WA7
Lang.: ENG.
Jrnl Ann.: 8311
Subfile: INDEX MEDICUS
Tags: Human
Desc.: Infant, Newborn; Retinal Detachment--Pathology (PA); Retrolental Fibroplasia--Classification (CL); *Retrolental Fibroplasia--Diagnosis (DI); Retrolental Fibroplasia--Pathology (PA)

Y015154 119 
1117384 83272384
Closed vitrectomy for severe retrolental fibroplasia in the infant.
Machemer R
Ophthalmology, May 1983, 90 (5) p436-41,
Jrnl Code: OI5
Contract/Grant No.: EY2903
Lang.: ENG.
Jrnl Ann.: 8311
Subfile: INDEX MEDICUS
Fifteen infants between the ages of 5 months and 2 years suffering from severe retrolental fibroplasia with near total and total retinal detachment and retrolental scar tissue formation were operated upon with closed vitrectomy. The surgical technique and the problems related to the smallness of the eye and the changes caused by RLF are discussed in detail. Seven retinas were reattached completely and one retina partially reattached. Vision was definitely improved, although the visual acuity was probably low.
Tags: Case Report; Human; Male; Support, U.S. Gov't, P.H.S.
Desc.: Cataract Extraction; Child, Preschool; Infant; Infant, Low Birth Weight; INFANT LBW; Infant, Newborn; Iris--Surgery (SU); Oxygen--Therapeutic Use (TU); *Retinal Detachment--Surgery (SU); Retrolental Fibroplasia--Etiology (ET); *Retrolental Fibroplasia--Surgery (SU); Scleral Buckling--Methods (MT); Surgical Instruments--Standards (ST) *Vitreous Body--Surgery (SU)
CAS Registry No.: 7782-44-7 (Oxygen)

Y015154 120 
1117383 83272383
 Vitamin E and retrolental fibroplasia. Improved visual outcome with early vitamin E.
Finer NN; Schindler RF; Peers KL; Grant GD
Ophthalmology, May 1983, 90 (5) p428-35,
Jrnl Code: OI5
Lang.: ENG.
Jrnl Ann.: 8311
Subfile: INDEX MEDICUS
Tags: Human
Desc.: Administration, Oral; Clinical Trials; Infant; Infant, Low Birth Weight; INFANT LBW; Infant, Newborn; Injections, Intramuscular; Random Allocation; Regression Analysis; *Retrolental Fibroplasia--Drug Therapy (DT); Retrolental Fibroplasia--Prevention and Control (PC); *Vitamin E--Therapeutic Use (TU)
CAS Registry No.: 1406-18-4 (Vitamin E)

Y015154 121 
1117382 83272382
Current therapy of retrolental fibroplasia. Retinopathy of prematurity.
Patz A
Ophthalmology, May 1983, 90 (5) p425-7,
Jrnl Code: OI5
Lang.: ENG.
Jrnl Ann.: 8311
Subfile: INDEX MEDICUS
Retrolental fibroplasia, frequently referred to now as the "retinopathy of prematurity, " has shown an increased incidence in recent years. This is apparently due to advances in neonatal care, which have resulted in a four- to five-fold improvement in the survival of the extremely low birthweight infants and it is these infants who are at the highest risk of developing retrolental fibroplasia. The use of large supplements of vitamin E, a known antioxidant, is discussed along with other forms of therapy.
Tags: Human
Desc.: Child; Clinical Trials; Cryosurgery; Infant, Low Birth Weight; INFANT LBW; Infant, Newborn; Injections, Intramuscular; Light Coagulation; Retrolental Fibroplasia--Etiology (ET); Retrolental Fibroplasia--Prevention and Control (PC); *Retrolental Fibroplasia--Therapy (TH); *Vitamin E--Therapeutic Use (TU)
CAS Registry No.: 1406-18-4 (Vitamin E)

Y015154 122 
1115710 83270710
Current status of retrolental fibroplasia.
Patz A
Dept. of Ophthalmology, Wilmer Ophthalmological Institute Baltimore, MD.
Metab Pediatr Syst Ophthalmol (US), 1982, 6 (3-4) p185-7,
ISSN 0277-9382
Jrnl Code: MUF
Lang.: ENG.
Jrnl Ann.: 8311
Subfile: INDEX MEDICUS
The improved survival of very premature infants is probably responsible for the moderate increase in incidence of RLF in the past few years. Because of the new cases of RLF, ophthalmologists should continue to focus their attention on this retinopathy of the premature infant. The pathogenesis of RLF and the role of oxygen, along with a brief discussion of newer concepts, are discussed.
Tags: Human
Desc.: Infant, Newborn; Infant, Premature; Oxygen Inhalation Therapy--Adverse Effects (AE); Oxygen--Pharmacodynamics (PD); Retinal Vessels--Drug Effects (DE); *Retrolental Fibroplasia--Classification (CL); Retrolental Fibroplasia--Etiology (ET); Retrolental Fibroplasia--Therapy (TH)
CAS Registry No.: 7782-44-7 (Oxygen)

Y015154 123 
1101111 83256111
The significance of ocular morbidity in very-low-birthweight infants to the Australian health service.
Keith CG; Kitchen WH
Dept. of Ophthalmology, Royal Children's Hospital, Parkville, Vic.
Aust J Ophthalmol (AUSTRALIA), Feb 1983, 11 (1) p29-31,
ISSN 0310-1177
Jrnl Code: 9G5
Lang.: ENG.
Jrnl Ann.: 8310
Subfile: INDEX MEDICUS
The survival rate of very-low-birthweight (VLBW) infants has greatly increased due to the introduction of intensive-care methods to neonatal nurseries. It was feared that this would also cause an increase in the amount of ocular morbidity associated with prematurity. In order to estimate this, 111 very-low-birthweight infants (birthweights less than or equal to 1500 g) were reviewed at two years of age. They comprised 63% of the total number of long-term surviving babies born at, or transferred in the neonatal period to, the Royal Women's Hospital, Melbourne, in 1977 and 1978. In 33% a significant ocular problem was detected; 19% had strabismus, 17% had a significant refractive error, 10% had cicatricial retrolental fibroplasia (RLF), and 2.7% were blind, due to optic atrophy associated with cerebral palsy. Other studies have shown that 7% of VLBW infants develop severe (Stage III) RLF, and 18% of these (1.26% of VLBW infants) will be socially or totally blind. In order to estimate the significance of VLBW infants to the ophthalmic health services, and to the organisations for the care of the visually handicapped, these figures can be extrapolated. Based on 1980 figures, it would be expected that approximately 1105 VLBW infants would survive annually, and nine would become blind from RLF, while 110 would have been affected by RLF. Thirty-three children would be blind from optic atrophy associated with cerebral palsy, 210 would have strabismus, and at least 187 would have a significant refractive error. VLBW infants will contribute significantly to the number of children requiring ocular care, and because of the high incidence of ocular abnormalities, it is recommended that routine screening of all VLBW infants be carried out at one year and two years of age.
Tags: Human
Desc.: Australia; Blindness--Occurrence (OC); Child, Preschool; *Eye Diseases--Occurrence (OC); Infant; *Infant, Low Birth Weight; *INFANT LBW; Infant, Newborn; Optic Atrophy--Occurrence (OC); Refractive Errors--Occurrence (OC); Retrolental Fibroplasia--Occurrence (OC); Strabismus--Occurrence (OC)

Y015154 124 
1097684 83252684
[Retinopathy of prematurity: a new score for the evaluation of prematurity of infants (I)--prematurity score P
Karaki T; Ohta I; Horiguchi M
Nippon Ganka Gakkai Zasshi, Mar 10 1983, 87 (3) p205-8,
ISSN 0029-0203
Jrnl Code: 22O
Lang.: JAPANESE
Summary Lang.: ENG.
Doc. Type: English Abstract
Jrnl Ann.: 8310
Subfile: INDEX MEDICUS
Tags: Human
Desc.: Birth Weight; Gestational Age; Infant, Newborn; *Infant, Premature; *Regression Analysis; *Retrolental Fibroplasia--Occurrence (OC)

Y015154 125 
1094010 83249010
Results and problems from work in the field of medical ethics in the GDR.
Luther E
Scand J Soc Med [Suppl] (SWEDEN), 1982, 31 p64-72,
ISSN 0301-7311
Jrnl Code: UDT
Lang.: ENG.
Jrnl Ann.: 8310
Subfile: INDEX MEDICUS
Tags: Female; Human
Desc.: *Communism; *Ethics, Medical; Germany, East; Infant, Newborn ; Morals; Pregnancy; PREGN; Religion and Medicine; Retrolental Fibroplasia--Etiology (ET); Risk

Y015154 126 
1091043 83246043
[Prevention of retrolental fibroplasia by administration of water soluble vitamin E (preliminary report)]
A retrolentalis fibroplasia megelozese vizoldekony E-vitamin adasaval (Elozetes kozlemeny).
Hervei S; Bors Z; Ugrai M; Malik T; Czappan P; Bohar A; Veli M
Orv Hetil (HUNGARY), Apr 3 1983, 124 (14) p811-2,
ISSN 0030-6002
Jrnl Code: OL8
Lang.: HUNGARIAN
Summary Lang.: ENG.
Doc. Type: English Abstract 
Jrnl Ann.: 8310
Subfile: INDEX MEDICUS
Tags: Human
Desc.: Blindness--Prevention and Control (PC); Clinical Trials; Infant, Newborn; *Retrolental Fibroplasia--Prevention and Control (PC); Solubility; Vitamin E--Administration and Dosage (AD); *Vitamin E--Therapeutic Use (TU)
CAS Registry No.: 1406-184 (Vitamin E)

Y015154 127 
1090918 83245918
Risk factors for retrolental fibroplasia.
Francois J
Ophthalmological Clinic, Univ. of Ghent, Belgium.
Ophthalmologica (SWITZERLAND), 1983, 186 (4) p189-96,
ISSN 0030-3?55
Jrnl Code: OIG
Lang.: ENG.
Jrnl Ann.: 8310
Subfile: INDEX MEDICUS
Besides oxygen administration and immaturity of the premature retinal vessels, there are other risk factors for retrolental fibroplasia: (1) respiratory distress syndrome; (2) multiple episodes of bradycardia apnoea; (3) exchange transfusions; (4) hyaline membrane disease; (5) anemia of prematurity; (6) hyperbilirubinemia; (7) avitaminosis E; (8) cardiovascular defects; (9) infectious diseases; (10) multiple births; (11) hypocalcemia; (12) hypothermia; (13) hemorr?agic tendency; (14) delayed coaptation of the retina, and (15) spastic diplegia.
Tags: Human
Desc.: Apnea--Complications (CO); Exchange Transfusion, Whole Blood--Adverse Effects (AE); EXCHANGE TRANSFUSION--Adverse Effects (AE); Hyaline Membrane Disease--Complications (CO); Infant, Newborn; Infant, Premature, Diseases; Oxygen Inhalation Therapy--Adverse Effects (AE); Respiratory Distress Syndrome--Complications (CO); Retinal Vessels--Abnormalities (AB); *Retrolental Fibroplasia--Etiology (ET); Risk

Y015154 128 
1082770 83237770
Central retinal arteries in hyperoxemia, and a possible role of fundusscopy in prevention of retrolental fibroplasia (retinopathia praematurorum).
Bracher D
Dept. of Pediatrics, Univ. of Berne, Switzerland.
Helv Paediatr Acta (SWITZERLAND), Mar 1983, 38 (1) p27-38,
ISSN 0018-022X
Jrnl Code: G59
Lang.: ENG.
Jrnl Ann.: 8310
Subfile: INDEX MEDICUS
Width and tortuosity of the central retinal arteries have been measured on fundus photographs of 9 full-term newborns under intensive care taken at least once in normoxemia and once in inadvertent hyperoxemia. In agreement with previous investigators no correlation was found between the actual paO2 and width of the arterioles. This is newly explained as a modification of the effect of paO2 on the vessel through acute asphyxia and adaptational phenomena. In opposition to the commonly accepted view on prevention of retrolental fibroplasia it is felt that the use of fundusscopy during intensive care should be reconsidered.
Tags: Case Report; Human; Support, Non-U.S. Gov't
Desc.: Asphyxia Neonatorum--Pathology (PA); Asphyxia Neonatorum--Therapy (TH); Critical Care; Fundus Oculi; Infant, Newborn; Ophthalmoscopy; Oxygen Inhalation Therapy; *Oxygen--Blood (BL); Partial Pressure; *Retinal Artery--Pathology (PA); *Retrolental Fibroplasia--Prevention and Control (PC)
CAS Registry No.: 7782-44-7 (Oxygen)

Y015154 129 
1072087 83227087
One hundred and twenty visually handicapped children below 7 years of age.
Ruud E
Hovseter Educational Centre for Blind and Partially Sighted Children and their Parents, Oslo, Norway.
Acta Ophthalmol [Suppl] (Copenh) (DENMARK), 1983, 157 p98-102,
ISSN 065-1451
Jrnl Code: 1FK
Lang.: ENG.
Jrnl Ann.: 8309
Subfile: INDEX MEDICUS
120 visually handicapped pre-school children are evaluated according to eye disease and its etiology, and the associated handicap, all related to the different levels of functioning. One third of the children fulfil the expectations on visually handicapped children. The group consists mainly of children suffering from hereditary ocular disorders and some children with retrolental fibroplasia. One third of the children are moderately or severely intellectually impaired, bearing a heavy burden of additional handicaps; many are born premature or dysmature, having suffered perinatal complications. The final third are children who fall outside the other 2 groups, some with a brain damage syndrome, some with light or moderate behavioural and emotional disturbance. The moderate and severe emotional disturbance and its relation to a brain dysfunctional syndrome are discussed.
Tags: Human
Desc.: Affective Symptoms--Complications (CO); Blindness--Complications (CO); Blindness--Diagnosis (DI); *Blindness--Rehabilitation (RH); *Brain Damage, Chronic--Complications (CO); Child Behavior Disorders--Complications (CO); Child; Child, Preschool; Infant; Vision Disorders--Complications (CO); Vision Disorders--Diagnosis (DI); *Vision Disorders--Rehabilitation (RH)

Y015154 130 
1070412 83225412
[Retrolental fibroplasia]
Retrolen?al'naia fibroplaziia.
Al'banskii VG; Medvedev AN
Vestn Oftalmol (USSR), Mar-Apr 1983, (2) p65-9,
ISSN 0042-465X
Jrnl Code: XAO
Lang.: RUSSIAN
Doc. Type: Review
Jrnl Ann.: 8309
Subfile: INDEX MEDICUS (50 Refs.)
Tags: Human
Desc.: Birth Weight; Cicatrix; Diagnosis, Differential; DIAG DIFFER ; Infant Newborn; Infant, Newborn, Diseases--Occurrence (OC); Infant, Premature; Oxygen Inhalation Therapy--Adverse Effects (AE); Prognosis; Retina--Pathology (PA); Retinal Vessels--Pathology (PA); *Retrolental Fibroplasia--Diagnosis (DI); Retrolental Fibroplasia--Etiology (ET); Retrolental Fibroplasia--Therapy (TH)

Y015154 131 
10694?4 83224494
[Children with very low birth weight]
Kinderen met zeer laag geboortegewicht.
Koppe JG
Tijdschr Ziekenverpl, Apr 26 1983, 36 (9) p267-71,
ISSN 0303-6456
Jrnl Code: VS3
Lang.: DUTCH
Doc. Type: Historical Article
Jrnl Ann.: 8309
Subfile: Nursing
Tags: Human
Desc.: Cerebral Palsy--Etiology (ET); Child, Preschool; Deafness--Etiology (ET); Follow-Up Studies; History of Medicine, 19th Cent. ; History of Medicine, 20th Cent.; Incubators, Infant--History (HI); Infant ; *Infant, Low Birth Weight; *INFANT LBW; Infant, Newborn; *Infant, Premature; *Intensive Care Units, Neonatal; Retrolental Fibroplasia--Etiology (ET)

Y015154 132 
1065149 83220149
Oxygenation and vasodilatation in relation to diabetic and other proliferative retinopathies.
Stefansson E; Landers MB 3d; Wolbarsht ML
Ophthalmic Surg, Mar 1983, 14 (3) p209-26,
ISSN 0?22-023X
Jrnl Code: OIC
Lang.: ENG.
Doc. Type: Review
Jrnl Ann.: 8309
Subfile: INDEX MEDICUS
The features of proliferative retinopathies are reviewed with reference to the vasodilatation that is a common stage in their pathogenesis. Vasodilatation in the retina is discussed in terms of a model in which vessel wall stretch in the retinal venules leads to leakage and proliferation. The beneficial effects of treatments such as panretinal photocoagulation and vitrectomy on the retinal hemodynamics are shown to agree with the hypothetical model. (179 Refs.)
Tags: Animal; Female; Human; Male; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.
Desc.: *Diabetic Retinopathy--Etiology (ET); Dilatation, Pathologic--Etiology (ET); Dogs; Infant, Newborn; Lasers--Therapeutic Use (TU); Mice; Models, Biological; Neovascularization--Etiology (ET); Oxygen Consumption; Rats; *Retinal Diseases--Etiology (ET); Retinal Diseases--Pathology (PA); Retinal Diseases--Surgery (SU); Retinal Vein; Retrolental Fibroplasia--Etiology (ET); Thrombosis--Complications (CO)

Y015154 133 
1062224 83217224
[Symptomatic treatment of retinopathy in premature infants by photocoagulation]
Objawowe leczenie retinopatii wczesniakow przy pomocy fotokoagulacji.
Helm W; Matzen C
Klin Oczna (POLAND), Oct 1982, 84 (10) p303-4,
ISSN 0023-2157
Jrnl Code: KWC
Lang.: POLISH
Summary Lang.: ENG.
Doc. Type: English Abstract
Jrnl Ann.: 8309
Subfile: INDEX MEDICUS
Tags: Human
Desc.: Infant, Newborn; *Light Coagulation--Methods (MT); *Retrolental Fibroplasia--Surgery (SU); Time Factors

Y015154 134 
1060611 83215611
Effects of indomethacin in premature infants with patent ductus arteriosus: results of a national collaborative study.
Gersony WM; Peckham GJ; Ellison RC; Miettinen OS; Nadas AS
Columbia Univ. College of Physicians and Surgeons, Pediatric Cardiology, New York, NY.
J Pediatr (US), Jun 1983, 102 (6) p895-906,
ISSN 0022-3476
Jrnl Code: JLZ
Contract/Grant No.: HL 23121
Lang.: ENG. 
Jrnl Ann.: 8309
Subfile: AIM; INDEX MEDICUS
Among 3559 newborn infants with birth weight less than 1750 gm, 421 developing a hemodynamically significant patent ductus arteriosus were entered into a randomized trial to evaluate the role of indomethacin in the management of PDA. Indomethacin given concurrently with usual medical therapy at the time of diagnosis resulted in ductal closure in 79%, versus 35% with placebo (P less than 0.001). Indomethacin as backup to usual medical treatment resulted in similar closure rates. To assess overall effects through hospital discharge, three management strategies were compared. Although mortality did not differ significantly, infants given indomethacin only if usual therapy failed (strategy 2) had a lower incidence of bleeding than those to whom indomethacin was given with initial medical therapy (strategy 1) and lower rates of pneumothorax and retrolental fibroplasia than those to whom no indomethacin was administered, with surgery the only backup to medical therapy (strategy 3).
Thus the administration of indomethacin only when medical treatment fails appears to be the preferable approach for the management of symptomatic PDA in premature infants.
Tags: Human; Support, U.S. Gov't, P.H.S.
Desc.: Clinical Trials; Ductus Arteriosus, Patent--Diagnosis (DI); *Ductus Arteriosus, Patent--Drug Therapy (DT); Indomethacin--Administration and Dosage (AD); Indomethacin--Adverse Effects (AE); *Indomethacin--Therapeutic Use (TU); Infant, Newborn; Infant, Premature, Diseases--Diagnosis (DI); *Infant, Premature, Diseases--Drug Therapy (DT); Placebos; Random Allocation
CAS Registry No.: 53-86-1 (Indomethacin)

Y015154 135 
1047536 83202536
Familial exudative vitreoretinopathy.
Bergen RL; Glassman R
Ann Ophthalmol (US), Mar 1983, 15 (3) p275-6,
ISSN 0003-4886
Jrnl Code: 5PA
Lang.: ENG.
Jrnl Ann.: 8308
Subfile: INDEX MEDICUS
Two sisters and a brother with the syndrome of familial exudative vitr?retinopathy are described (FEV). Findings associated with this condition include temporal neovascularization, vitreous hemorrhage, and retinal detachment. Familial exudative vitreoretinopathy is a genetic syndrome with nearly complete penetrance but widely variable expressivity. The differential diagnosis is fairly extensive. This condition is sometimes confused with retrolental fibroplasia, and FEV is probably a more frequently occurring disease than previously thought, because of confusion with RLF. The pathophysiologic mechanism, natural history, and optimal treatment of this disease are matters of debate. With active surgical management, three of the four eyes which presented to us for treatment have visual acuity of 20/30 or better.
Tags: Case Report; Female; Human 
Desc.: Child; Eye Diseases--Familial and Genetic (FG); *Hemorrhage--Familial and Genetic (FG); Pedigree; Retinal Detachment--Familial and Genetic (FG); *Retinal Diseases--Familial and Genetic (FG); Syndrome; Telangiectasis--Familial and Genetic (FG); *Vitreous Body

Y015154 136 
1046445 83201445
Penicillamine and retinopathy of prematurity [letter]
Hatvani IL; Lakatos L
Am J Ophthalmol (US), May 1983, 95 (5) p719-20,
ISSN 0002-9394
Jrnl Code: 3OQ
Lang.: ENG.
Jrnl Ann.: 8308
Subfile: AIM; INDEX MEDICUS
Tags: Human
Desc.: Infant, Low Birth Weight; INFANT LBW; Infant, Newborn; *Penicillamine--Therapeutic Use (TU); *Retrolental Fibroplasia--Prevention and Control (PC)
CAS Registry No.: 52-67-5 (Penicillamine)

Y015154 137 
1045271 83200271
Neonatal oxygen toxicity and its prevention: D-penicillamine offers benefits without harmful side-effects.
Oroszlan G; Lakatos L; Karmazsin L
Dept. of Paediatrics, Univ. Medical School, Debrecen.
Acta Paediatr Acad Sci Hung (HUNGARY), 1982, 23 (4) p459-71,
ISSN 0001-6527
Jrnl Code: 1JQ
Lang.: ENG.
Doc. Type: Review
Jrnl Ann.: 8308
Subfile: INDEX MEDICUS (107 Refs.)
Tags: Human
Desc.: Infant, Newborn; Oxygen Consumption; *Oxygen--Adverse Effects (AE); Oxygen--Physiology (PH); *Penicillamine--Therapeutic Use (TU) ; *Retrolental Fibroplasia--Prevention and Control (PC); Vitamin E--Therapeutic Use (TU)
CAS Registry No.: 1406-18-4 (Vitamin E); 52-67-5 (Penicillamine); 7782-44-7 (Oxygen)

Y015154 138 
1023792 83178792
Ocular morbidity in infants of very low birth weight.
Keith CG; Kitchen WH
Royal Children's Hospital, Melbourne.
Br J Ophthalmol (ENGLAND), May 1983, 67 (5) p302-5,
ISSN 0007-1161
Jrnl Code: AZK
Lang.: ENG.
Jrnl Ann.: 8308
Subfile: INDEX MEDICUS
In the years 1977-8, 258 infants weighing less than 1500 g were born at, or transferred to, the Royal Women's Hospital, Melbourne; 177 (68.5%) survived, and 111 of these attended for an ophthalmic examination. Significant ocular lesions were found in 37 (33%): 21 (19%) children had squint, 19 (17%) had a significant refractive error, 11 (10%) had cicatricial retrolental fibroplasia (RLF), and 3 (2.7%) had very poor vision due to optic atrophy associated with cerebral palsy. No children were blind owing to RLF, indicating that the recent increase in survival rate of infants of very low birth weight has not been accompanied by an increase in the prevalence of severe RLF. In those children with neither cerebral palsy nor RLF the prevalence of squint was 11% and of refractive error 13%. Myopia was found mainly in children who had shown RLF changes in the neonatal period. It is recommended that infants of very low birth weight continue to be screened in the premature nursery for RLF, and also at the age of 2, for the detection of refractive errors and squint.
Tags: Human
Desc.: Australia; *Eye Diseases--Occurrence (OC); Follow-Up Studies ; *Infant, Low Birth Weight; *INFANT LBW; Infant, Newborn; Optic Atrophy--Occurrence (OC); Refractive Errors--Occurrence (OC); Retrolental Fibroplasia--Occurrence (OC); Strabismus--Occurrence (OC)

Y015154 139 
1021752 83176752
Battered baby syndrome in an infant with severe retinopathy of prematurity.
Fritch CD
Ann Ophthalmol, Feb 1983, 15 (2) p132-3,
ISSN 0003-4886
Jrnl Code: 5PA
Lang.: ENG.
Jrnl Ann.: 8307
Subfile: INDEX MEDICUS
Tags: Case Report; Human; Male
Desc.: *Battered Child Syndrome; *Child Abuse; Infant; Retinal Detachment--Complications (CO); *Retrolental Fibroplasia--Complications (CO)

Y015154 140 
1020117 83175117
[Genetic eye diseases and blindness]
Nakajima A
Nippon Ganka; Gakkai Zasshi (JAPAN), 1982, 86 (11) p1834-58,
ISSN 0300-9203
Jrnl Code: 22O
Lang.: JAPANESE
Summary Lang.: ENG.
Doc. Type: English Abstract
Jrnl Ann.: 8307
Subfile: INDEX MEDICUS
Tags: Human; Support, Non-U.S. Gov't
Desc.: Adolescence; Adult; Aged; Blindness--Familial and Genetic (FG); Blindness--Occurrence (OC); *Blindness--Prevention and Control (PC); Cataract--Congenital (CN); Child; Child, Preschool; Infant; Infant, Newborn ; Japan; Middle Age; Retrolental Fibroplasia--Occurrence (OC)

Y015154 141 
1019594 83174594
Transcutaneous PO2 monitoring during treatment with continuous positive airway pressure in infants with idiopathic respiratory distress syndrome.
Kamper J; Nielsen G; Erichsen G; Filtenborg JA; Lillquist K; Pedersen VF Skjolda J; Stabell I
Dept. of Pediatrics, Odense Univ. Hospital, Denmark.
Acta Anaesthesiol Scand (DENMARK), Feb 1983, 27 (1) p1-4,
ISSN 0001-5172
Jrnl Code: 08O
Lang.: ENG.
Jrnl Ann.: 8307
Subfile: INDEX MEDICUS
During a 20-month period, 20 infants with idiopathic respiratory distress syndrome (IRDS) were treated with continuous positive airway pressure (CPAP) when they required at least 40% inspired oxygen. The infants were allocated to monitoring with either repeated blood-gas determinations according to the usual practice or continuous transcutaneous PO2 measurements supplemented by blood-gas measurements only when judged necessary. The groups were comparable with regard to birth weight and gestational age, and did not differ significantly with regard to effectiveness or duration of the CPAP treatment, survival rates (90 versus 80%) or number of complications. None developed retrolental fibroplasia. However, PtcO2 monitoring resulted in significantly less hypo- and hyperoxaemia and the number of blood-gas analyses performed during CPAP therapy amounted to only 0.6 per infant per day in the transcutaneously monitored group as against 5.3 in the other group. We propose that PtcO2 monitoring should now be the method of choice and that the use of umbilical artery catheterization should be restricted to selected groups of very low birth-weight infants and to infants in need of ventilator therapy.
Tags: Comparative Study; Human
Desc.: Blood Gas Analysis--Methods (MT); Clinical Trials; Infant, Newborn; *Oxygen--Blood (BL); Partial Pressure; *Positive Pressure Respiration; Prospective Studies; *Respiratory Distress Syndrome--Therapy (TH); Skin--Blood Supply (BS)
CAS Registry No.: 7782-44-7 (Oxygen)

Y015154 142 
1013665 83168665
Speculation on carbon dioxide and retrolental fibroplasia [letter]
Wolbarsht ML; George GS; Kylstra J; Landers MB 3d; Shearin WA Jr
Pediatrics (US), May 1983, 71 (5) p859-60,
ISSN 0031-4005
Jrnl Code: OXV
Lang.: ENG.
Jrnl Ann.: 8307
Subfile: AIM; INDEX MEDICUS
Tags: Animal; Human
Desc.: *Carbon Dioxide; Carbon Dioxide--Blood (BL); Models, Biological; *Retrolental Fibroplasia--Etiology (ET)

Y015154 143 
1013619 83168619
Another view of carbon dioxide and retrolental fibroplasia [letter]
Gole GA; Gannon BJ
Pediatrics (US), Apr 1983, 71 (4) p665-6,
ISSN 0031-4005
Jrnl Code: OXV
Lang.: ENG.
Jrnl Ann.: 8307
Subfile: AIM; INDEX MEDICUS
Tags: Human
Desc.: *Carbon Dioxide--Physiology (PH); Retinal Vessels--Physiology (PH); *Retrolental Fibroplasia--Physiopathology (PP); Vasoconstriction

Y015154 144 
1013604 83168604
Infants weighing 1, 000 grams or less at birth: developmental outcome for ventilated and nonventilated infants.
Rothberg AD; Maisels MJ; Bagnato S; Murphy J; Gifford K; McKinley K
Dept. of Pediatrics, The Milton S. Hers